ID A0A384DCH0_URSMA Unreviewed; 521 AA.
AC A0A384DCH0;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Neurotrophin receptor-interacting factor homolog isoform X3 {ECO:0000313|RefSeq:XP_008704700.1, ECO:0000313|RefSeq:XP_008704701.1};
GN Name=ZNF274 {ECO:0000313|RefSeq:XP_008704700.1,
GN ECO:0000313|RefSeq:XP_008704701.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008704701.1};
RN [1] {ECO:0000313|RefSeq:XP_008704700.1, ECO:0000313|RefSeq:XP_008704701.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008704700.1,
RC ECO:0000313|RefSeq:XP_008704701.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00187}.
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DR RefSeq; XP_008704700.1; XM_008706478.2.
DR RefSeq; XP_008704701.1; XM_008706479.2.
DR RefSeq; XP_008704702.1; XM_008706480.1.
DR GeneID; 103677232; -.
DR CTD; 10782; -.
DR OrthoDB; 5261021at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 5.
DR Gene3D; 1.10.4020.10; DNA breaking-rejoining enzymes; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23232; KRAB DOMAIN C2H2 ZINC FINGER; 1.
DR PANTHER; PTHR23232:SF137; ZINC FINGER PROTEIN 8; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR SUPFAM; SSF47353; Retrovirus capsid dimerization domain-like; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00187};
KW Receptor {ECO:0000313|RefSeq:XP_008704700.1,
KW ECO:0000313|RefSeq:XP_008704701.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 56..134
FT /note="SCAN box"
FT /evidence="ECO:0000259|PROSITE:PS50804"
FT DOMAIN 178..251
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 371..398
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 399..426
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 427..454
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 455..482
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 483..510
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 279..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 521 AA; 58833 MW; 67E2CF9CE350F3B7 CRC64;
MKIEVVEVLT LNQEVARPRN AQIRALYAED EALSPDVLGG PTQQLGKHPA DPEAARQRFR
GFCFEEVAGP REALARLREL CRQWLQPEVH SKEQMLELLV LEQFLGALPR KLRMWVESQH
PEDCQEAVSL VEDVTWISEE ETLPAQDPIC SLQTTAPQEE KGENMTTWPA KAPPEEPVTF
LDVAVDFSKE EWGLLDTMQR TEYHDVMLET FGHLVSVGWE TTLESKELTS KSDIPEKELA
HDLKIEEISR DDTCSPRSRD VSQGEAQEVL DTALKQVGPT QEETLPQKSP PSQANTGLVT
SHISLQKTLP RKRLRKRGSR VKKVTRSPCV KIHQKGHKGE KARENSGCGR AFSRSAQQIT
FTRIHKGSQV CRCSECGKTF RNPRYFSVHK KIHTGEKPYV CQDCGKAFVQ SSSLTQHQRV
HTGERPFECH ECGRAFNDRS AISQHLRTHT GAKPYQCQAC GKAFRQSSHL IRHQRTHTGE
RPYTCNKCGK AFTQSSHLIG HQKTHSGVKC KKKPPTSQSS S
//
