ID A0A384DCM8_URSMA Unreviewed; 719 AA.
AC A0A384DCM8;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Disintegrin and metalloproteinase domain-containing protein 30 {ECO:0000313|RefSeq:XP_008704574.1};
GN Name=ADAM30 {ECO:0000313|RefSeq:XP_008704574.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008704574.1};
RN [1] {ECO:0000313|RefSeq:XP_008704574.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008704574.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_008704574.1; XM_008706352.1.
DR AlphaFoldDB; A0A384DCM8; -.
DR STRING; 29073.ENSUMAP00000000102; -.
DR GeneID; 103677118; -.
DR KEGG; umr:103677118; -.
DR CTD; 11085; -.
DR OrthoDB; 5406290at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 4.10.70.10; Disintegrin domain; 1.
DR InterPro; IPR006586; ADAM_Cys-rich.
DR InterPro; IPR018358; Disintegrin_CS.
DR InterPro; IPR001762; Disintegrin_dom.
DR InterPro; IPR036436; Disintegrin_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR001590; Peptidase_M12B.
DR InterPro; IPR002870; Peptidase_M12B_N.
DR InterPro; IPR034027; Reprolysin_adamalysin.
DR PANTHER; PTHR11905; ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN; 1.
DR PANTHER; PTHR11905:SF148; DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 30; 1.
DR Pfam; PF08516; ADAM_CR; 1.
DR Pfam; PF00200; Disintegrin; 1.
DR Pfam; PF01562; Pep_M12B_propep; 1.
DR Pfam; PF01421; Reprolysin; 1.
DR PRINTS; PR00289; DISINTEGRIN.
DR SMART; SM00608; ACR; 1.
DR SMART; SM00050; DISIN; 1.
DR SUPFAM; SSF57552; Blood coagulation inhibitor (disintegrin); 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS50215; ADAM_MEPRO; 1.
DR PROSITE; PS00427; DISINTEGRIN_1; 1.
DR PROSITE; PS50214; DISINTEGRIN_2; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00276};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|PROSITE-ProRule:PRU00276}.
FT TRANSMEM 674..696
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 190..381
FT /note="Peptidase M12B"
FT /evidence="ECO:0000259|PROSITE:PS50215"
FT DOMAIN 387..473
FT /note="Disintegrin"
FT /evidence="ECO:0000259|PROSITE:PS50214"
FT DOMAIN 617..650
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT ACT_SITE 327
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 326
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 330
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 336
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT DISULFID 445..465
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00068"
FT DISULFID 640..649
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 719 AA; 81332 MW; E0CBDE20DA90B423 CRC64;
MLVLVALLVD ALGEDLLFHP EWGFESYEII IPKKLSFRGG QQGAVQQVSY LLQVKDKKYV
LHLWPKRFLL PRNLKVFSFT EQEKLLEDHP YIPRDCNYIG LVEGTQDSEA TLSTCTGSLR
GILKIDEERY QIEPLKASSS FEHVMYLLKK EDKFQNQTCG LTNDELEKQM ARSENMARLR
DYPGSYKHQK YMELALVFDH SRFLFSDSNL TRLIQDAILL TGIMDTFFRD VNMRLHLQGV
EIWTHGDKLN VQQMTSQEIL STFLKYRTTT LSARISADWA HLYITSAFIH SLGWAYIGGA
CMEKYSGSVS SYTNLNILEA SRMSAHELGH GVGMRHDTVY CQCRGKQTCI MGTGSSGFSN
CSYIEYFNHV YSGAECLNNI PGLGYVVERC GNKIVEGDEE CDCGSREDCK KDRCCQPDCK
LTQGANCSTG LCCHNCRFRP LGYMCRKEEN ECDLAEYCNG ISSFCPDDAY KHDGTICKSN
SLCFKKRCHS RYAQCQNIFG PDAREAPDQC YHAVNLMGDQ YGNCGIVGVR TYKACTRENA
VCGRLQCINV KSIPELPDHT TIISTHLRAE NLLCWGLGYH KSMIPMGIPD IGVISDGTPC
GFDRLCVNRT CVHISVLNLE CLPKKCNHRG VCNNNQNCHC VYGWAPPFCE EVGYGGSIDS
GPARRLKEEV PAPVQVVSIM LMRLIFLILS VIAVFFRRLI EQYIKPTQRE TPPINIQNK
//