ID   A0A384DCT1_URSMA        Unreviewed;      1247 AA.
AC   A0A384DCT1;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   03-AUG-2022, sequence version 2.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Pleckstrin homology-like domain family B member 2 isoform X7 {ECO:0000313|RefSeq:XP_008704822.2};
GN   Name=PHLDB2 {ECO:0000313|RefSeq:XP_008704822.2};
OS   Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008704822.2};
RN   [1] {ECO:0000313|RefSeq:XP_008704822.2}
RP   IDENTIFICATION.
RC   TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008704822.2};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_008704822.2; XM_008706600.2.
DR   KEGG; umr:103677325; -.
DR   OrthoDB; 5477608at2759; -.
DR   Proteomes; UP000261680; Unplaced.
DR   CDD; cd14673; PH_PHLDB1_2; 1.
DR   CDD; cd22265; UDM1_RNF168; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR037810; PHLDB1/2/3_PH.
DR   PANTHER; PTHR12156:SF21; PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY B MEMBER 2; 1.
DR   PANTHER; PTHR12156; PLECKSTRIN HOMOLOGY-LIKE DOMAIN, FAMILY B, MEMBER 3; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261680}.
FT   DOMAIN          1137..1240
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          66..155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          187..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          398..423
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          892..914
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          580..685
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          730..800
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1029..1088
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        66..120
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        128..144
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        196..220
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        399..421
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        893..914
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1247 AA;  140892 MW;  B70152CBFBD475B1 CRC64;
     MAEHSHMQKQ LDLQNGSLEA GFVANSLEDN SPNVMESLSP KKYSSSLRFK ANGDYSGSYL
     TLSQPVAAKR SPSPLGSTVR SSPSLAKIQG SKQFSCDGTD KTISMKPPTP LLSTSPSLSG
     YPLGRADFDH YTGRDSERSL RLAEKPPYSK YSSRNKSHDN VYFLGGLEGR KASGSLLAMW
     NGSPLSDRGP SPISRSGAAS MPSSPKQARK MSIQDNLTLQ PKLSRHKEPA SENLALRTRK
     YSGSSLSHMG AYSRSLPRLH RATDNQLTPL SLPPRHSLGN AKRTKLGEKD LPHSIIDNDN
     YLNFSSLSSG ALPYKPSASE GHSYVSSALS VPASPRVARK MLLASTSSCT SDDLDRVPYA
     GPGPGHSFPP GEPDRVFAAR RNFSCGSVEF DDAELDSLRQ ASGTPQPVLR ERKSSISSIS
     GRDDLMDYHR RQREERLREQ EMERLERQRL ETILSLCAEY TKPDSRLSTG TTVADVQKIN
     KELEKLQLSD EESVFEEAVV SPDSRYRCHP KGSLQDVDSA GFGSGGQSSA GFLSPRSIRN
     DDLLRDLTSA FLKTPSESAY LSILPKTPEG INEEQRIQEL AAMEETRIAI LNNLEELEQK
     IKDINDQMDE SSRELDMECA LLDGEQKSET TELMKEKEIL DHLNRKIAEL EKNIVGEKTK
     EKVKLDAERE KLERLQEIYS EQKTQLDNCP ESMREQLQQQ LKRDADLLDV ESKHFEDLEF
     QQLERESRLD EEKENLTQQL LREVAEYQRN IVTRKEKISA LKKQANHIVQ QAQREQDHFV
     KEKNNLIMML QREKENLCNL EKKYSSLSGG KGFPVNPSTL KEGYISVNEI NEPCVSSTNL
     SPSTQFPADA DAVATGPTTA VLVSQPQNKE HFRSLEERKK QHKEGLYLSD TLPRKKTTPS
     ISPHFSSATM GRSTAPKAHL PLGQSNSCGS VLPHSLATMT KDSESRRMLR GYNHQQMSEG
     QRQKSSEFYN RTASESNVYL NSFHYPDHSY KDQAFDTLSL DSSDSMETSI SACSPDNISS
     ASTSNIARIE EMERLLKQAH AEKTRLLESR EREMEAKKRA LEEEKRRREL LEKRLQEETS
     QRQKLIEKEV KIREKQRAQA RPLTRYLPVR KEDFDLRSHV ETAGHNIDTC YHVSITEKTC
     RGFLIKMGGK IKTWKKRWFV FDRNKRTFSY YADKHEAKLK GVIYFQAIEE VYYDHLKNAN
     KSPNPLLTFS VKTHDRIYYM VAPSPEAMRI WMDVIVTGAE GYTHFLL
//