ID A0A384DD09_URSMA Unreviewed; 1593 AA.
AC A0A384DD09;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=RB1 inducible coiled-coil 1 {ECO:0000313|Ensembl:ENSUMAP00000012887};
DE SubName: Full=RB1-inducible coiled-coil protein 1 isoform X1 {ECO:0000313|RefSeq:XP_040482102.1};
GN Name=RB1CC1 {ECO:0000313|Ensembl:ENSUMAP00000012887,
GN ECO:0000313|RefSeq:XP_040482102.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_040482102.1};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000012887}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_040482102.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_040482102.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_008704903.1; XM_008706681.1.
DR RefSeq; XP_040482102.1; XM_040626168.1.
DR STRING; 29073.ENSUMAP00000012887; -.
DR Ensembl; ENSUMAT00000015292.1; ENSUMAP00000012887.1; ENSUMAG00000009553.1.
DR KEGG; umr:103677420; -.
DR OMA; RWIMYVE; -.
DR OrthoDB; 2878794at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:1990316; C:Atg1/ULK1 kinase complex; IEA:Ensembl.
DR GO; GO:0000421; C:autophagosome membrane; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0034045; C:phagophore assembly site membrane; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0000045; P:autophagosome assembly; IEA:Ensembl.
DR GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0001889; P:liver development; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
DR GO; GO:0045793; P:positive regulation of cell size; IEA:Ensembl.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
DR GO; GO:1903059; P:regulation of protein lipidation; IEA:Ensembl.
DR GO; GO:0061709; P:reticulophagy; IEA:Ensembl.
DR CDD; cd17060; Ubl_RB1CC1; 1.
DR InterPro; IPR040040; ATG11.
DR InterPro; IPR019460; Atg11_C.
DR PANTHER; PTHR13222; RB1-INDUCIBLE COILED-COIL; 1.
DR PANTHER; PTHR13222:SF1; RB1-INDUCIBLE COILED-COIL PROTEIN 1; 1.
DR Pfam; PF10377; ATG11; 1.
PE 4: Predicted;
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680}.
FT DOMAIN 1476..1586
FT /note="Autophagy-related protein 11 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF10377"
FT REGION 639..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 859..911
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1006..1116
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1140..1239
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1276..1322
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1367..1394
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1451..1478
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 639..670
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1593 AA; 182705 MW; 239084159A4F814E CRC64;
MKLYVFLVNT GTTLTFDTEL TVQTVADLKH AIHSKYKIAI QHQVLVVNGG ECMAADRRVC
TYSAGTDTNP IFLFNKEMIL CDRPPAIPKT TFSTENDMEI KVEESLMMPA VFHTVASRTQ
LAVEMYEVAK KLCSFCEGLV HDEHLQHQGW AAIMANLEDC SNSYQKLLFK FESIYSNYLQ
SIEDIKLKLT HLGTAVSVMA KIPLLECLTR HSYRECLGRL DSLPEHEGSE KAEMKTSTEL
VLSPDMPRTT SQSLLTSFHK SVEHIAPDTT DAENGKEIRE SCQSTVQQDE TSVDAKDGDL
PFFNVSLLDW INVQDRPNDV ESLVRKCFDS MSRLDPRIIR PFIAECRQTI AKLDNQNMKA
IKGLEDRLYA LDQMIASCSR LVNEQKELAQ GFLANQMRAE NLKDASVLPD LCLSHANQLM
IMLQNHRKLL DIKQKCTTAK QELANNLHVR LKWCCFVMLH ADQDGEKLQA LLRLVIELLE
RVKIVEALST VPQMYCLAVV EVVRRKMFIK HYREWAGALV KDGKRLYEAE KSKRESFGKL
FRKSFLRNRL FRGLDSWPSS FCTQKPRKFD CELPDISLKD LQFLQSFCPS EVQPLLRVPL
LCDFEPLHQH VLALHNLVKA AQSLDEMSQT ITDLLTEQKA SMSQTSPQSA SSPRIESATG
IATTTSPRTP PPLTVQDPLC PAVCPLEELS PDSIDAHTFD FETIPHPNIE QTIHQVSLDL
DSLAESPESD FMSAVNEFVI EENLSSPNPI SDPQSPEMMV ESLYSSVINA IDSRRMQDTN
VCGKEDLGDH TSLNVQLEKC RVVAQDSHFS IQTIKEDLCH LRTFVQKEQC DFSNSLKCTA
LEIRNIIEKV KCCVEITLNE KHQKELQSLK SEYEGKLDAL VKESEENENK IKKLKGDLVC
LEEVLQNKDN EFALVKHEKE AVICLQNEKD QKLLEMENIM HTQNCEINEL KQSREIVLED
LKKLHVENVE KMQLLRTELQ CLEQSHLKEL EDALHVRHTQ EFEKVITDHR VSLEKLKKEN
QQQIDQIQES HATVIQEKEQ QLEELKLKVS DLSDMRCKLE VELALKEAET DEIKILLEES
RAQQKETLKS LLEQETENLR TEISKLNQKI QDNNENYQVG LAELRTLMTI EKDQCISELI
SRHEEESDIL KAELNKVTSL HHQAFEIEKN LKGEIAELQS KLDAELSALE KQKDEKLIQQ
EEKYEATIQK LEKDKEELVM SQEQDREQLI QKLNFEKEAA IQTALKEFKL ERETVEKELL
EKVKHLENQI AKSLAIESAR EDSSSLVAEL QEKLQEEKAK FLEQLEEQEK RKNEEMQNVR
TSLIAEQQTN FNTVLTREKM RKENIINDLS DKLKSTMQQQ ERDKDLIESL SEDRARLLEE
KKKLEEEVSK LRSSSFVPSA YVAAAPELYG ACAPELPGET ERSAMETQDE GKVDSAMETS
MMSVQENIHM LSEEKQRIML LERTLQLKEE ENKRLNQRLM SQSMSSVSSR HSEKIAIRDF
QVGDLVLIIL DERHDNYVLF TVSPTLYFLH SESLPALDLK PGEGASGASR RPWVLGKVME
KEYCQAKKAQ NRFKVPLGTK FYRVKAVSWN KKV
//
