ID A0A384DG87_URSMA Unreviewed; 280 AA.
AC A0A384DG87;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=TNF receptor superfamily member 14 {ECO:0000313|Ensembl:ENSUMAP00000014177};
DE SubName: Full=Tumor necrosis factor receptor superfamily member 14 isoform X1 {ECO:0000313|RefSeq:XP_008706001.1};
GN Name=TNFRSF14 {ECO:0000313|Ensembl:ENSUMAP00000014177,
GN ECO:0000313|RefSeq:XP_008706001.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008706001.1};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000014177}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008706001.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008706001.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR RefSeq; XP_008706001.1; XM_008707779.2.
DR STRING; 29073.ENSUMAP00000014186; -.
DR Ensembl; ENSUMAT00000016825.1; ENSUMAP00000014177.1; ENSUMAG00000010441.1.
DR GeneID; 103678434; -.
DR KEGG; umr:103678434; -.
DR CTD; 8764; -.
DR OMA; GWELPPW; -.
DR OrthoDB; 24515at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00185; TNFRSF; 1.
DR CDD; cd10582; TNFRSF14; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR022332; TNFR_14.
DR InterPro; IPR034031; TNFRSF14/UL144_N.
DR PANTHER; PTHR46838; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 14; 1.
DR PANTHER; PTHR46838:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 14; 1.
DR Pfam; PF00020; TNFR_c6; 3.
DR PRINTS; PR01965; TNFACTORR14.
DR SMART; SM01411; Ephrin_rec_like; 2.
DR SMART; SM00208; TNFR; 4.
DR SUPFAM; SSF57586; TNF receptor-like; 3.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_008706001.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..38
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 39..280
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041072496"
FT TRANSMEM 209..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 77..119
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 77..119
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 120..162
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 120..162
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DISULFID 78..93
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 144..162
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 280 AA; 30093 MW; 910CA37908A74AFF CRC64;
MEPLRGWEPP PWSLTPKADA LHQALYLLLL GSLPCALAMA PCKEEEYPVG SECCPKCSPG
YRVKEACGEL TGTLCVPCDP GTYTAHLNGL SECLQCRVCD PALGLVTRQK CSRTENTVCV
CDQGHFCISE DGDDCAECRP HTLCRPGQRV RARGTERQDR VCEDCPSGTF SPSGTLEECQ
PWTTCSGPFQ TEAEPGTSSS DITCSSRGLY VFVGSLVLIG VLCGLIVLGI RMKNRRSPGG
PTKARLFHQV PRAPPDITTV ALEETASVSP VSLPCVTGRE
//
