ID   A0A384DGR6_URSMA        Unreviewed;       696 AA.
AC   A0A384DGR6;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Rho guanine nucleotide exchange factor 16 {ECO:0000313|Ensembl:ENSUMAP00000014554};
GN   Name=ARHGEF16 {ECO:0000313|Ensembl:ENSUMAP00000014554};
OS   Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=29073 {ECO:0000313|Ensembl:ENSUMAP00000014554};
RN   [1] {ECO:0000313|Ensembl:ENSUMAP00000014554}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2019) to UniProtKB.
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DR   RefSeq; XP_008706024.1; XM_008707802.1.
DR   AlphaFoldDB; A0A384DGR6; -.
DR   STRING; 29073.ENSUMAP00000014552; -.
DR   Ensembl; ENSUMAT00000017260.1; ENSUMAP00000014554.1; ENSUMAG00000010695.1.
DR   OMA; FHPYVVY; -.
DR   OrthoDB; 12272at2759; -.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd01221; PH_ephexin; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR047271; Ephexin-like.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR047270; PH_ephexin.
DR   PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR12845:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 16; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
FT   REGION          22..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          46..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          91..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          178..246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          617..642
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        204..233
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   696 AA;  77783 MW;  A8E2DAAFB56482D9 CRC64;
     MSQRHSDSSL EEKLLEYRFH SELRLDAKGN PASGLPMVRD SLQVRDNAAF QLDSSAPPPR
     SPKEEGPRAV VLSTQSPAAL KMGTQQLIPR SLAVSSKAKT PARHQSFGAA VLSKEAARRD
     PRPGSAPSFS LDDMDVDTGP EGALRRNLRN RSYRAAMKSL GAPGGERAPI QLSPKLQALA
     EEPSPSPARC PAKNKRTLGR KRAHKGSFKD DPGFYQEIRE RGLNTSHESD DDLLDEPPSP
     EGTGKVDAPI VVKSYRPAQI TWSQLPEVVE SGLLDKLPAE ERKRQEAIFE ILTSEFSYQH
     SLGILVAEFL QSRELRATMT QTEHHHLFSN ILDVLSASQR FFEALEQRHK AQVCVEDISD
     ILEEHAEKHF HPYIAYCSNE VYQQRVLQKL TNSNAAFHEA LKEIEKRPAC GGLPMISFLI
     LPMQRVTRLP LLTDTLCLKS QGHPERYKAA SRALKAISKL VRRCNEGAHK MERTELMYTL
     HTQLDFGKVK SLPLISASRW LLKRGELFVV EETGLFRKLA SRPTCYLFLF NDVLVVTKKK
     SEDSFVVQDY AQVDHIRVQK MEPSDPSLLG AGGGSRSSSV PHPFQVTLLR NSEGRQENIL
     LSSDSASDRA RWITALTHQE RQGQGPTNKG EGQRAGGAQT LPSPAPHLCS GWFYGERLRD
     GEMGWFPEDF ARCITSRVAV EGNVRRMERL RVETDV
//