ID A0A384DHA2_URSMA Unreviewed; 129 AA.
AC A0A384DHA2;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 {ECO:0000256|ARBA:ARBA00018681};
DE AltName: Full=Complex I-B15 {ECO:0000256|ARBA:ARBA00030212};
DE AltName: Full=NADH-ubiquinone oxidoreductase B15 subunit {ECO:0000256|ARBA:ARBA00030987};
GN Name=NDUFB4 {ECO:0000313|Ensembl:ENSUMAP00000035147,
GN ECO:0000313|RefSeq:XP_008706413.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008706413.1};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000035147}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008706413.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008706413.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000256|ARBA:ARBA00003195}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000256|ARBA:ARBA00011533}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000256|ARBA:ARBA00004298}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004298}; Matrix side
CC {ECO:0000256|ARBA:ARBA00004298}.
CC -!- SIMILARITY: Belongs to the complex I NDUFB4 subunit family.
CC {ECO:0000256|ARBA:ARBA00007260}.
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DR RefSeq; XP_008706413.1; XM_008708191.2.
DR STRING; 29073.ENSUMAP00000035147; -.
DR Ensembl; ENSUMAT00000041552.1; ENSUMAP00000035147.1; ENSUMAG00000025258.1.
DR GeneID; 103678783; -.
DR KEGG; umr:103678783; -.
DR CTD; 4710; -.
DR OMA; REYLLHY; -.
DR OrthoDB; 5343231at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IEA:Ensembl.
DR GO; GO:0006979; P:response to oxidative stress; IEA:Ensembl.
DR InterPro; IPR009866; NADH_UbQ_OxRdtase_NDUFB4_su.
DR PANTHER; PTHR15469:SF0; NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 4; 1.
DR PANTHER; PTHR15469; NADH-UBIQUINONE OXIDOREDUCTASE B15 SUBUNIT; 1.
DR Pfam; PF07225; NDUF_B4; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 87..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 129 AA; 15024 MW; 5F19BDB2FB71BCB7 CRC64;
MSFPKYESSR LATLPATLDP GEYNVSPEAR KAQAERLAIR SRLKREYLLH YNDPSRQGLI
EDPALIRWTY ARSANIYPNF RPTPKTSLLG ALFGFGPLFF WFYVFKTDRD KKEKLIQEGK
LDRTLSISY
//
