ID A0A384DHU4_URSMA Unreviewed; 914 AA.
AC A0A384DHU4;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Rubicon autophagy regulator {ECO:0000313|Ensembl:ENSUMAP00000004140};
GN Name=RUBCN {ECO:0000313|Ensembl:ENSUMAP00000004140};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Ensembl:ENSUMAP00000004140};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000004140}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
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DR RefSeq; XP_008706622.1; XM_008708400.1.
DR AlphaFoldDB; A0A384DHU4; -.
DR STRING; 29073.ENSUMAP00000004130; -.
DR Ensembl; ENSUMAT00000005042.1; ENSUMAP00000004140.1; ENSUMAG00000003349.1.
DR OMA; KDVIFPW; -.
DR OrthoDB; 126314at2759; -.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR CDD; cd17686; RUN_RUBCN; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR InterPro; IPR025258; RH_dom.
DR InterPro; IPR048569; RUBC_PIKBD.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR PANTHER; PTHR45971; PHOX (PX) DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45971:SF3; RUN DOMAIN BECLIN-1-INTERACTING AND CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13901; RH_dom; 1.
DR Pfam; PF21054; RUBC_PIKBD; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM01175; DUF4206; 1.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR PROSITE; PS50826; RUN; 1.
PE 4: Predicted;
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT REGION 175..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 223..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 492..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..527
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 914 AA; 102292 MW; 3E1838C4F38431A2 CRC64;
MQSILYHGLI HDQQVCCRQT DYWQFVKDIR WLSPHSALHV EKFISLHENG QSSADGVSER
AVAELWLQHS LQCHCLSAQL RPLLGDRQYI RKFYTDTAFL LSNAHVTAML QCLEAVEQNN
PRLLAQIDAS MFARKHESPL LVTKSQSLTA LPGSTYTPST SYAQHSYFGS FSSLHQSVPN
HGSERRSTSF SLSGPARKPQ ESREHLSPEQ DQAFQAPLLS VPALARDPPS TPNEMSSSTL
TSPLEASWVS SQNDSPSDAS EGPEYLAIGN LDPRGRTASC QSHSSNAESS SSNLFSSSSS
QKPDSAASSL GEQEGGGQSQ LSSVLRRSSF SEGQTLTATS GTKKSHTRSH SDTNIASRGA
PESCNDKSKL RGPLPYSGPS SEVSTPSSLY MEYEGGQYLC SGEGMFRRPS EGQSLISYLS
EQDFGSCADL EKENAHFSIS ESLIAAIELM KCNMMSQGLE EEEEEEEDSD REIQELKQKI
RLRRQQIRTK NLPPVYQETE HGTGFRVTSS SSQFSSRDST QFSDSGSADE VDEFEIQDAD
IRRSTASNSK SFASSQAFSH CFLHSTSAEA VAMGLLKQFE GMQLPAASEL EWLVPEHDAP
QKLLPIPDSL PISPDDGQHA DIYKLRIRVR GNLEWAPPRP QIIFNVHPAP TRKIAVAKQN
YRCAGCGIRT DPDYIKRLRY CEYLGKYFCQ CCHENAQMVI PSRVLRKWDF SKYYVSNFSK
DLLIKIWNDP LFNVQDINSA LYRKVKLLNQ VRLLRIQLYH MKNMFKTCRL AKELLDSFDT
VPGHLTEDLH LYSLNDLTAT RKGELGPRLA ELTRAGAAHV ERCMLCQAKG FICEFCQNED
DIIFPFELHK CRTCEECKAC YHKACFKSGS CPRCERLQAR RELLAKQSLE SYMSDYEEEP
TEALALEATV LEAT
//
