ID A0A384DI62_URSMA Unreviewed; 531 AA.
AC A0A384DI62;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Bardet-Biedl syndrome 4 protein isoform X1 {ECO:0000313|RefSeq:XP_008706737.1};
GN Name=BBS4 {ECO:0000313|RefSeq:XP_008706737.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008706737.1};
RN [1] {ECO:0000313|RefSeq:XP_008706737.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008706737.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}.
CC -!- SIMILARITY: Belongs to the BBS4 family.
CC {ECO:0000256|ARBA:ARBA00023778}.
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DR RefSeq; XP_008706737.1; XM_008708515.2.
DR AlphaFoldDB; A0A384DI62; -.
DR GeneID; 103679014; -.
DR KEGG; umr:103679014; -.
DR CTD; 585; -.
DR OrthoDB; 5481067at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44186; -; 1.
DR PANTHER; PTHR44186:SF1; BARDET-BIEDL SYNDROME 4 PROTEIN; 1.
DR Pfam; PF13414; TPR_11; 1.
DR Pfam; PF13181; TPR_8; 4.
DR SMART; SM00028; TPR; 8.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 4.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 107..140
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 174..207
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 208..241
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 310..343
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 447..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 531 AA; 59633 MW; AB96DC0DB262C301 CRC64;
MTKPGNFERH CLLPRTPFPA SVESQKPRLK KAQEFPILEK QNWLIHLHYI RKDYEACKAV
IKEQLQETQG LCEYAIYVQA LIFRLEGNIQ ESLELFQTCA ILSPQCADNL KQVARSLFLL
GKHKAAIEVY NEAAKLNQKD WEICHNLGVC YIYLKQFTKA QDQLHNALHL NRHDLTYIML
GKIHLLEGDL DKAIEIYKKA VEFSPENTEL LTTLGLLYLQ LGIYQKAFEH LGNALTYDPT
NYKAILAAGS MMQTHGDFDV ALTKYRVVAC AVPESPPLWN NIGMCFFGKK KYVAAISCLK
RANYLAPFDW KILYNLGLVH LTMQQYASAF HFLSAAINLQ PKMGELYMLL AVALTNLEDP
ENAKRAYAEA VRLDKCNPLV NLNYAVLLYN QGERKGALAQ YQEMERKVSL LKDSSSLEFD
SEMVEMAQKL GAALQVGEAL VWTKPVKDTK SKHRTTSTSK AAGFQQPLGS NQALGQAMSS
AAAHRKLPSG AGTSQLTKPP SLLPEPEPTA EAHPAEASAQ IRENRSRMTP E
//
