ID A0A384DJ23_URSMA Unreviewed; 2610 AA.
AC A0A384DJ23;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 03-AUG-2022, sequence version 2.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Collagen alpha-5(VI) chain {ECO:0000313|RefSeq:XP_008707028.2};
GN Name=COL6A5 {ECO:0000313|RefSeq:XP_008707028.2};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008707028.2};
RN [1] {ECO:0000313|RefSeq:XP_008707028.2}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008707028.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Collagen VI acts as a cell-binding protein.
CC {ECO:0000256|ARBA:ARBA00043858}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the type VI collagen family.
CC {ECO:0000256|ARBA:ARBA00044000}.
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DR RefSeq; XP_008707028.2; XM_008708806.2.
DR STRING; 29073.ENSUMAP00000024476; -.
DR KEGG; umr:103679288; -.
DR OrthoDB; 5359724at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR CDD; cd01472; vWA_collagen; 2.
DR CDD; cd01450; vWFA_subfamily_ECM; 5.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 9.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR22588:SF4; COLLAGEN ALPHA-5(VI) CHAIN; 1.
DR PANTHER; PTHR22588; UNCHARACTERIZED; 1.
DR Pfam; PF01391; Collagen; 2.
DR Pfam; PF00092; VWA; 9.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00327; VWA; 9.
DR SUPFAM; SSF53300; vWA-like; 10.
DR PROSITE; PS50234; VWFA; 9.
PE 3: Inferred from homology;
KW Collagen {ECO:0000313|RefSeq:XP_008707028.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..2610
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035476460"
FT DOMAIN 30..202
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 236..413
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 442..612
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 628..797
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 814..991
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1005..1182
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1758..1903
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1963..2154
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 2289..2483
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 1402..1726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2260..2280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2584..2610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1416..1433
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1465..1485
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1515..1554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2260..2275
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2610 AA; 288153 MW; B21927D906A8DE26 CRC64;
MKSLLIIFIL TLWTETLADQ SPEPGPEYAD VVFLVDSSDH LGTKSFPLVK AFIHKTVSGL
PVDAHKYRVA LAQYSDRLHS EFQLATFKSR NPMLNHLKKN FGFLGGSLRT GHALREAHRT
FFSAPAGGRD KKQFPPILVV LASAQSEDDV EEASKALRED GVRIVSVGLQ SASEEELKAM
ATSRFHFNLR SARDLGAFSQ NMTQIIKEAT QYRDGAAPHS VGVPFPVACQ KDSLADLIFL
VDESVGTKQN LRNLQNFLRN IAASMDVRYN CTRLGLMSYS DRTNTISLLN SSTTQYEFQE
QIQKLSVQAG KSNAGAAIEK MRLEAFSESS GSRRAQGVPQ IAVLVTHRPS TDEVRDVAIQ
LRLQDVTVFG MNIQGADETQ LEEIASYPPR QMVSMLKSYA DLETYSKNFQ KKLRNEIWSQ
ISTRAEQMDL DRTGCIDTKE ADIYFLIDGS TSIQGKHFEQ IKEFMLAVTG MFSIGPDKVQ
VGAVQYSHKM RVEFYINDNS NNVNLKNAIL NIEQLQGNTY TGEALNFTLS IIKEDRKHRT
SQVPCYLIVL TDGRSADDVL EPAERLRAEQ VTIHAVGIGE ANKVQLQQIA GGEERVSFGQ
NFDSLRSIKN EVVHRICTEK GCEDMKADIM FLVDSSGSIG HENFGKMKTF MKSLLAKIQI
GPDRTHIGVI QFSDKTREEF QLNKYFTQNE ISDAIDRMSL IDKNTLTGNA LISVDQYFTP
ARGARIGVKK FLILITDGEA QDAVRDPAKA LRDKGVVIFS VGVYGANRTQ LEEISGDGNL
VFQVENFDDL KTIESKLIFR VCALHDCKNI KVLDIVFVLD HSGSINTQEQ ENMMALTIHL
VKKADVGSDR VRIGALKYSD YPEILFHLGK YSNRSSVIEH LRRRRDTGGN TYTARALDHT
NIMFTEEYGS RIQQNVKQML IVITDGASHD RTLLNETALK LRNRGIDIYA VGVGPADQLE
LEAMAGNKSK TFHVDNFNKL EDIYLPLQES MCINAHEWCD IQEADVVFFC DGSDMVSNSE
FVTMTTFVSE LIDHFNIQNQ KIKIGLAQFG SGFQKIIELK NSLTIPELKT QIQSIPKSKG
FPRMDLALKK VKAMFDPSSG GRRNAGVPQT LVVITSGDPY YDVADEVKIL RNLGICVLVW
GIGNIHKEQL LPITGHSEKI VTLQDFNKLM NVDVKKRMVR EICQSCGKTN CFMDIVVGFD
ISTHLRGQPL FHGHPRLRSY LPGILEDISS IGRVSCGAGS DVQVNVAFKV NNDREFPAKF
QIYQKAIFDS LLQVTVNGPS HLNAQFLQSL WDTFKDQSKS QGQVLLIFSD GLGGESEIML
ENQSDRLREA GLDALLVVSL NTTAHDEFSS FEFGKGFDYM THLTIGMREL GKMLSQYLGN
VAEKTCCCTL CKCSGTPGPY GSRGLQAAKG SRGLKGSRGH RGEDGDPGRR GDIGPLGDKG
IAGCPGEQGQ KGAKGFSGSK GEQGEDGIDG LDGEEGFHGP SGEKGEKGDP GSQGSPGSRG
PPGGYGEKGF PGDPGNPGQN SNIKGQKGSK GEQGRQGRTG QKGTPGNPNS RGNRGREGQR
GPPGASGEPG NRGPEGTQGA DGLQGPQGLN GIPGRKGEKG GEGHKGPQGS SGPVGAKGNV
GSPGPSGKKG EPGILGDPGP MGQAGQRGRQ GDYGIPGYGP MGRKGIKGPR GFPGDMGQKG
AVGDPGIPGG PGPKGFRGLT RTVGLKGEEG PPGPPGPPGR RGMKGMAGKP VYSQCDLIQF
MRDHSPCWKG TCPVYPTELV FALDQSYGIS EQRFNEMREI VTSIVNDLNI KESNCPVGAR
VVVVSYDSGT SYLIRRSDYR NKKQLLQLIS QIKYRPPTEA RDVGNAMRFV ARNVFKRTYA
GANVRKVAVF FSNGQAASRS SIITATMEFS ALDISPAVFA LNERIFLEAF EFDNTGTFQV
IPVSPNGEYE PLEKFQHCTL CYDKCFPNEC IKEIFLPEDA YMDVAFLLDN SQTIANEEFK
AVKTLVSSMI DNFKIASDPG ISNFGDRIAL LSYSPWDRSR KKKGVVKTEF GFTTFNDRVL
MKRHIQSSLR QLEGETTIGH TLLWVVENLF PQTPNLRKHK VLFVISAGEY HERKEFLKKV
ALRAKCQGYV IVVISLGSTY KEDMEELASY PLDHHLIQLG RIHKPDLDYI TKFIRPFVYS
VRRGFNEYPP PVLENDCRLI SRGEAYQNSD PLLTPEPHEI SSGENSFIGQ ELSAGKDSSF
LWEDNGSAHL VYVPSRVLTP QELTITYAQD WDSEEIASLT SGHENHGRKE EPGLTNEPGD
TSLQEYYMDV AFLIDASQRI GNDEFKEVKA FLISVLDYFH IAPDPLTSML GDRVAVLSYS
PPGYMPNSEE CPVYLEFDLV TYNSIHQMKH HLQDSFQQLN GDVFIGHALQ WTIENVFVGT
PNLRKNKVIF VISAGETNPL DKEVLRNVAL RAKCQGYSIF VFSFGPIHND KELEELASHP
LDHHLVQLGR THKPDLNYIT KFVKPFVHLI RRAINKYPPA DLRPKCVNIT SPNPENVGSG
NNVFLIPEVY KIETGNSELF DEFGSQEQHS LVLGNNPSNG SETTTDLIQK LYMLFSTGEL
VMNDKEETHS EEMPALADGK LDKKDGEDSR
//
