ID   A0A384DJM3_URSMA        Unreviewed;       595 AA.
AC   A0A384DJM3;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=DNA polymerase alpha subunit B {ECO:0000256|ARBA:ARBA00018596, ECO:0000256|PIRNR:PIRNR018300};
GN   Name=POLA2 {ECO:0000313|Ensembl:ENSUMAP00000013074,
GN   ECO:0000313|RefSeq:XP_008707223.1};
OS   Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008707223.1};
RN   [1] {ECO:0000313|Ensembl:ENSUMAP00000013074}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2019) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_008707223.1}
RP   IDENTIFICATION.
RC   TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008707223.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Accessory subunit of the DNA polymerase alpha complex (also
CC       known as the alpha DNA polymerase-primase complex) which plays an
CC       essential role in the initiation of DNA synthesis.
CC       {ECO:0000256|PIRNR:PIRNR018300}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PIRNR:PIRNR018300}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase alpha subunit B family.
CC       {ECO:0000256|ARBA:ARBA00007299, ECO:0000256|PIRNR:PIRNR018300}.
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DR   RefSeq; XP_008707223.1; XM_008709001.2.
DR   STRING; 29073.ENSUMAP00000013074; -.
DR   Ensembl; ENSUMAT00000015506.1; ENSUMAP00000013074.1; ENSUMAG00000009665.1.
DR   GeneID; 103679454; -.
DR   KEGG; umr:103679454; -.
DR   CTD; 23649; -.
DR   OrthoDB; 49016at2759; -.
DR   Proteomes; UP000261680; Unplaced.
DR   GO; GO:0005658; C:alpha DNA polymerase:primase complex; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:Ensembl.
DR   GO; GO:0006269; P:DNA replication, synthesis of RNA primer; IEA:Ensembl.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:Ensembl.
DR   Gene3D; 3.60.21.60; -; 2.
DR   Gene3D; 1.10.8.530; DNA polymerase alpha-primase, subunit B, N-terminal domain; 1.
DR   InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR   InterPro; IPR043034; DNA_pol_alpha_B_N_sf.
DR   InterPro; IPR016722; DNA_pol_alpha_bsu.
DR   InterPro; IPR013627; Pol_alpha_B_N.
DR   PANTHER; PTHR23061; DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT; 1.
DR   PANTHER; PTHR23061:SF12; DNA POLYMERASE ALPHA SUBUNIT B; 1.
DR   Pfam; PF04042; DNA_pol_E_B; 1.
DR   Pfam; PF08418; Pol_alpha_B_N; 1.
DR   PIRSF; PIRSF018300; DNA_pol_alph_2; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW   ECO:0000256|PIRNR:PIRNR018300}; Nucleus {ECO:0000256|PIRNR:PIRNR018300};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261680}.
FT   DOMAIN          24..235
FT                   /note="DNA polymerase alpha subunit B N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08418"
FT   DOMAIN          338..545
FT                   /note="DNA polymerase alpha/delta/epsilon subunit B"
FT                   /evidence="ECO:0000259|Pfam:PF04042"
FT   REGION          103..163
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        105..163
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   595 AA;  65657 MW;  5F50FFED509212DB CRC64;
     MSVSAQRLVE ELQIFDVECE AALTEKLVEL CILYGQNEEG MVAELIAFCT RTGKVCLTSE
     TLNSFEHECL SKKLSRASRD GGHAGARDIV SIQELIEAEE EEESLLNSYT TPSKGSQKRA
     ITTPETPLTK RTVSTRSPHQ LLSPSSFSPS ATPSQKYSSR NNRGEVVTSF GSAQGVSWSG
     RGGAGNISLK VLGGPESLTG SYKSMFQKLP DIRDVLTCKI EELGTELKEH YKIEAFTPVL
     LPAQEPVTLL GQIGCDTNGK LNSKSVILEG DREHSSGAQI PVDLSELKEY SLFPGQVVVM
     EGINTTGRKF IATKLYEGVP LPFYQPTKED EDFEQNMVLV ACGPYTTSDS ITYDPLLDLI
     AIINRDQPDV CILFGPFLDA KHEQVENCLL TSPFEDIFKQ CLRTIIEGTR SSGSHLVFVP
     SVRDVHREPV YPQPPFSYSD LSRDDRKRVQ FVSEPCSLSI NGVIFGLTST DLLFHMGAEE
     ISSASGTSDR LSRILKHILT QRSYYPLYPP QEDMAIDYES FYMYAQLSVT PDVFIIPSEL
     KYFVKDVLGC VCVNPGRLTK GQVGGTFGRL FLRRQQAAGG EGRQSPCTAV QVVRI
//