ID A0A384DJN4_URSMA Unreviewed; 506 AA.
AC A0A384DJN4;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 03-AUG-2022, sequence version 2.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=phosphoenolpyruvate carboxykinase (GTP) {ECO:0000256|ARBA:ARBA00012306};
DE EC=4.1.1.32 {ECO:0000256|ARBA:ARBA00012306};
GN Name=PCK2 {ECO:0000313|RefSeq:XP_008707000.2};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008707000.2};
RN [1] {ECO:0000313|RefSeq:XP_008707000.2}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008707000.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC {ECO:0000256|ARBA:ARBA00004742}.
CC -!- SIMILARITY: Belongs to the phosphoenolpyruvate carboxykinase [GTP]
CC family. {ECO:0000256|ARBA:ARBA00005796}.
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DR RefSeq; XP_008707000.2; XM_008708778.2.
DR AlphaFoldDB; A0A384DJN4; -.
DR STRING; 29073.ENSUMAP00000031392; -.
DR KEGG; umr:103679274; -.
DR OrthoDB; 5471652at2759; -.
DR UniPathway; UPA00138; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004613; F:phosphoenolpyruvate carboxykinase (GTP) activity; IEA:UniProtKB-EC.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR CDD; cd00819; PEPCK_GTP; 1.
DR Gene3D; 3.90.228.20; -; 1.
DR Gene3D; 3.40.449.10; Phosphoenolpyruvate Carboxykinase, domain 1; 1.
DR Gene3D; 2.170.8.10; Phosphoenolpyruvate Carboxykinase, domain 2; 1.
DR HAMAP; MF_00452; PEPCK_GTP; 1.
DR InterPro; IPR018091; PEP_carboxykin_GTP_CS.
DR InterPro; IPR013035; PEP_carboxykinase_C.
DR InterPro; IPR008209; PEP_carboxykinase_GTP.
DR InterPro; IPR035077; PEP_carboxykinase_GTP_C.
DR InterPro; IPR035078; PEP_carboxykinase_GTP_N.
DR InterPro; IPR008210; PEP_carboxykinase_N.
DR PANTHER; PTHR11561; PHOSPHOENOLPYRUVATE CARBOXYKINASE; 1.
DR PANTHER; PTHR11561:SF11; PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP], MITOCHONDRIAL; 1.
DR Pfam; PF00821; PEPCK_GTP; 1.
DR Pfam; PF17297; PEPCK_N; 1.
DR SUPFAM; SSF68923; PEP carboxykinase N-terminal domain; 1.
DR SUPFAM; SSF53795; PEP carboxykinase-like; 1.
DR PROSITE; PS00505; PEPCK_GTP; 1.
PE 3: Inferred from homology;
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680}.
FT DOMAIN 1..140
FT /note="Phosphoenolpyruvate carboxykinase GTP-utilising N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF17297"
FT DOMAIN 144..501
FT /note="Phosphoenolpyruvate carboxykinase C-terminal P-loop"
FT /evidence="ECO:0000259|Pfam:PF00821"
SQ SEQUENCE 506 AA; 55934 MW; 7A35D5E4EFA197FB CRC64;
MSPADFQQAV DERFPGCMQG RTMYVLPFSM GPVGSPLSRI GVQLTDSAYV VASMRIMTRL
GTPVLQALGD GDFVKCLHSV GHPLTGQGEP VNQWPCNPEK TLIGHVPDQR EIISFGSGYG
GNSLLGKKCF ALRIASRLAR DEGWLAEHML ILGITNPAGK KRYVAAAFPS ACGKTNLAMM
RPALPGWKVE CVGDDIAWMR FDSDGRLRAI NPENGFFGVA PGTSATTNPN AMATIQSNTL
FTNVAETSDG GVYWEGIDQP LPPGVTVTSW LGKPWKPGDK EPCAHPNSRF CAPARQCPIM
DPAWEAPEGV PIDAIIFGGR RPKGVPLVYE AFSWRHGVFV GSAMRSESTA AAEHKGKIIM
HDPFAMRPFF GYNFGRYLEH WLSMEERKGA RLPRIFHVNW FRRDEAGRFL WPGFGENARV
LDWICRRLEG EDSARETPIG LVPKEGALDL SGLGAIDTTQ LFSLPKDFWE QEVRDIRSYL
TEQVNQDLPK EVLAELEALE GRVRRM
//
