ID A0A384DPL5_URSMA Unreviewed; 242 AA.
AC A0A384DPL5;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 03-AUG-2022, sequence version 2.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Hairy and enhancer of split-related protein HELT isoform X1 {ECO:0000313|RefSeq:XP_008708725.2};
GN Name=HELT {ECO:0000313|RefSeq:XP_008708725.2};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008708725.2};
RN [1] {ECO:0000313|RefSeq:XP_008708725.2}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008708725.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_008708725.2; XM_008710503.2.
DR AlphaFoldDB; A0A384DPL5; -.
DR KEGG; umr:103681008; -.
DR OrthoDB; 2968390at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd11408; bHLH-O_HELT; 1.
DR Gene3D; 6.10.250.980; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR PANTHER; PTHR10985:SF8; HAIRY AND ENHANCER OF SPLIT-RELATED PROTEIN HELT; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF158457; Orange domain-like; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 10..65
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 87..122
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
SQ SEQUENCE 242 AA; 27022 MW; 6A7E9782E25FA094 CRC64;
MSDKLKDRKR TPVSHKVIEK RRRDRINRCL NELGKTVPMA LAKQSSGKLE KAEILEMTVQ
YLRALHSADF PRGREKAELL AEFANYFHYG YHECMKNLVH YLTTVERMET KDTKYARILA
FLQSKARLGT EPAFQPLGSL PEPDFSYQLH PAGPELAGHS PGEASVFPQG AAPGPFPWPH
GTARSPALPY LPSAPVPLPS PAQQHSPFLA PVQGLDRHYL NLIGHAHPNA LNLHPSQHPT
VL
//
