ID   A0A384DPW6_URSMA        Unreviewed;      1065 AA.
AC   A0A384DPW6;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   03-AUG-2022, sequence version 2.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=ATPase MORC2 isoform X1 {ECO:0000313|RefSeq:XP_008708825.2};
GN   Name=MORC2 {ECO:0000313|RefSeq:XP_008708825.2};
OS   Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008708825.2};
RN   [1] {ECO:0000313|RefSeq:XP_008708825.2}
RP   IDENTIFICATION.
RC   TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008708825.2};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_008708825.2; XM_008710603.2.
DR   AlphaFoldDB; A0A384DPW6; -.
DR   STRING; 29073.ENSUMAP00000022274; -.
DR   KEGG; umr:103681094; -.
DR   OrthoDB; 933627at2759; -.
DR   Proteomes; UP000261680; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0000792; C:heterochromatin; IEA:Ensembl.
DR   GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:Ensembl.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:Ensembl.
DR   GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR   GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR   GO; GO:0045814; P:negative regulation of gene expression, epigenetic; IEA:Ensembl.
DR   GO; GO:0045869; P:negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; IEA:Ensembl.
DR   GO; GO:0090309; P:positive regulation of DNA methylation-dependent heterochromatin formation; IEA:Ensembl.
DR   CDD; cd16931; HATPase_MORC-like; 1.
DR   Gene3D; 3.30.40.100; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR041006; Morc_S5.
DR   InterPro; IPR011124; Znf_CW.
DR   PANTHER; PTHR23337:SF7; ATPASE MORC2; 1.
DR   PANTHER; PTHR23337; ZINC FINGER CW-TYPE COILED-COIL DOMAIN PROTEIN 1; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF17942; Morc6_S5; 1.
DR   Pfam; PF07496; zf-CW; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   PROSITE; PS51050; ZF_CW; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
SQ   SEQUENCE   1065 AA;  121405 MW;  25635344F788466E CRC64;
     MAFTNYSSLN RAQLTFEYLH TNSTTHEFLF GALAELVDNA RDADATRIDI YAERREDLRG
     GFMLCFLDDG AGMDPSDAAS VIQFGKSAKR TPESTQIGQY GNGLKSGSMR IGKDFILFTK
     KEDTMTCLFL SRTFHEEEGI DEVIVPLPTW NARTREPVTD NVEKFAIETE LIYKYSPFHN
     EEEVMTQFMK IPGDSGTLVI IFNLKLMDNG EPELDIISNP RDIQMAETSP EGTKPERRSF
     RAYAAVLYID PRMRIFIHGH KVQTKRLSCC LYKPRMYKYT SSRFKTRAEQ EVKKAEHVAR
     IAEEKAREAE SKARTLEVRL GGDLTRDSRV MLRQVQNTAI TLRREADVKK RIKEAKQRAL
     KEPKELNFVF GVNIEHRDLD GMFIYNCSRL IKMYEKVGPQ LEGGMACGGV VGVVDVPYLV
     LEPTHNKQDF ADAKEYRHLL RAMGEHLAQY WKDIAIAQRG IIKFWDEFGY LSANWNQPPS
     SELRYKRRRA MEIPTTIQCD LCLKWRTLPF QLSSVEKDYP DTWVCSMNPD PEQDRCEASE
     QKQKVPLGTF RKDLKTQEEK QKQLTEKIRQ QQEKLEALQK TTPIRSQADL KKLPLEVTTR
     PSTEEPARRP QRPRSPPLPA VIKNAPSRPP SLQAPRPASQ PRKAPVISST PKPPALAARE
     EASTSRLLQP PEAPRKPTNT PVKTAPRPTP VVQPLSPSLL PNSRSPREVP APRAIKTPVV
     KKPEPPTKLS PTTPGRKRTL GVSDEEEAEE EAERRRERSK RGKFAVKEEK KDLNELSDSA
     GEEEPADLKR AQKDKGLHVE VRVNREWYTG RVTAVEVGKH VVRWKVKFDY VPTDTTPRDR
     WVEKGSEDVR LMKPPSPEYQ SPDTQQEGGE EEEEEVVVAQ QAVAMAEPST SDCIRIEPDT
     TAPSTNHETI DLLVQILRNC LRYFLPPSFP ISKKELSAMN SDELISFPLK EYFKQYEVGL
     QNLCHSYQSR ADSRAKASEE SLRTSERKLR ETEEKLQKLR TNIVALLQKV QEESVVPTLA
     AQHPDQEGWR WCGCLGLIPA RPTDIDINTD DELDAYIEDL ITKGD
//