ID A0A384ILS8_9ACTN Unreviewed; 593 AA.
AC A0A384ILS8;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase family protein {ECO:0000313|EMBL:PZT77667.1};
GN ORFNames=DNK56_31425 {ECO:0000313|EMBL:PZT77667.1};
OS Streptomyces sp. AC1-42W.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2218666 {ECO:0000313|EMBL:PZT77667.1, ECO:0000313|Proteomes:UP000249154};
RN [1] {ECO:0000313|EMBL:PZT77667.1, ECO:0000313|Proteomes:UP000249154}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AC1-42W {ECO:0000313|EMBL:PZT77667.1,
RC ECO:0000313|Proteomes:UP000249154};
RA De Leon M.P., Montecillo A.D., Siringan M.A.T., Kim S.-G., Rosana A.R.R.;
RT "Near complete genome sequences of Streptomyces sp. strains AC1-42W
RT isolated from bat guano of Cabalyorisa Cave, Pangasinan, Philippines.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC {ECO:0000256|ARBA:ARBA00005086}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PZT77667.1}.
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DR EMBL; QKWY01000002; PZT77667.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A384ILS8; -.
DR Proteomes; UP000249154; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 2.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000249154}.
FT DOMAIN 7..185
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 188..284
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 314..491
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 494..590
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 593 AA; 62443 MW; EB66569C6BA3048D CRC64;
MDTPLSTIAV VGLGTMGTGI AEVLARSGRE VVGIDVDDAA ARRAVASLEA STARAVERGR
LTERERRDTL ARFRTFSELR AAADAELVIE VVPESYEIKQ RVFRELDAIV SPTAILATGT
NALSVTRLAA ESQRPERVLG LHFFNPAPAM KLVEVVSSVL TAPPAVEAVT ELARALGKEP
VAVGDRPGFV ADGLLFGYLN QAAAMYEANY ATREDIDAAM RLGCGLPMGP LALLDLIGID
TARTVLEAMY AASHDRLHAP APVLGQLGAA GLTGRKAGRG FYTYAEPGSQ TVVPDALTPA
PRGGEAAGRP VRSVGVAGSG TMASGIAEVF AKAGYDVVLA ARGEEKADLA KARIAKSLDR
SVGKGRLTPE ARDETLARIT PAGSLDAFAG VDLAVEAVAE DLAVKRQLFA ALDKVCRPGA
VLATTTSSLP VVAIARATGR PEDVVGMHFF NPAPAMKLVE VVRTVLTADD VHATVHEVCL
KVRKHPVDCG DRAGFIVNAL LFPYLNNAIK MVEEHYASLD DIDAAMKLGG GYPMGPFELL
DVVGLDVSLA IEKVLHGEFR DPGLAPAPLL EHLVAAGCLG RKTGRGFREY ARR
//
