ID A0A384KJI9_PLAKH Unreviewed; 499 AA.
AC A0A384KJI9; A0A1A7VTS0; B3LBD6;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=GTPase Era, mitochondrial {ECO:0000256|ARBA:ARBA00019149};
DE AltName: Full=ERA-like protein 1 {ECO:0000256|ARBA:ARBA00030975};
GN ORFNames=PKNH_0422400 {ECO:0000313|EMBL:CAA9986862.1};
OS Plasmodium knowlesi (strain H).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=5851 {ECO:0000313|EMBL:CAA9986862.1, ECO:0000313|Proteomes:UP000031513};
RN [1] {ECO:0000313|EMBL:CAA9986862.1, ECO:0000313|Proteomes:UP000031513}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H {ECO:0000313|EMBL:CAA9986862.1,
RC ECO:0000313|Proteomes:UP000031513};
RA Pain A., Boehme U., Berry A.E., Mungall K., Finn R., Jackson A.P.,
RA Mourier T., Mistry J., Pasini E.M., Aslett M., Balasubrammaniam S.,
RA Borgwardt K., Brooks K., Carret C., Carver T.J., Cherevach I.,
RA Chillingworth T., Clarke T.G., Galinski M.R., Hall N., Harper D.,
RA Harris D., Hauser H., Ivens A., Janssen C.S., Keane T., Larke N., Lapp S.,
RA Marti M., Moule S., Meyer I.M., Ormond D., Peters N., Sanders M.,
RA Sanders S., Sergeant T.J., Simmonds M., Smith F., Squares R., Thurston S.,
RA Tivey A.R., Walker D., White B., Zuiderwijk E., Churcher C., Quail M.A.,
RA Cowman A.F., Turner C.M.R., Rajandream M.A., Kocken C.H.M., Thomas A.W.,
RA Newbold C.I., Barrell B.G., Berriman M.;
RT "The genome of Plasmodium knowlesi strain H, a zoonotic malaria parasite
RT with host range from monkey to man.";
RL Nature 455:799-803(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004637};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004637}.
CC Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. Era GTPase family. {ECO:0000256|ARBA:ARBA00007921,
CC ECO:0000256|PROSITE-ProRule:PRU01050}.
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DR EMBL; AM910986; CAA9986862.1; -; Genomic_DNA.
DR RefSeq; XP_002260654.1; XM_002260618.1.
DR AlphaFoldDB; A0A384KJI9; -.
DR STRING; 5851.A0A384KJI9; -.
DR GeneID; 7322634; -.
DR KEGG; pkn:PKNH_0422400; -.
DR VEuPathDB; PlasmoDB:PKNH_0422400; -.
DR InParanoid; A0A384KJI9; -.
DR OMA; KAKNQFW; -.
DR OrthoDB; 5490026at2759; -.
DR Proteomes; UP000031513; Chromosome 4.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006576; P:biogenic amine metabolic process; IEA:InterPro.
DR CDD; cd04163; Era; 1.
DR CDD; cd22534; KH-II_Era; 1.
DR Gene3D; 3.30.300.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR012381; EutP_PduV.
DR InterPro; IPR030388; G_ERA_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR005662; GTPase_Era.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR009019; KH_sf_prok-type.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR42698; GTPASE ERA; 1.
DR PANTHER; PTHR42698:SF4; GTPASE ERA, MITOCHONDRIAL; 1.
DR Pfam; PF01926; MMR_HSR1; 1.
DR Pfam; PF10662; PduV-EutP; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54814; Prokaryotic type KH domain (KH-domain type II); 1.
DR PROSITE; PS51713; G_ERA; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|PROSITE-
KW ProRule:PRU01050}; Hydrolase {ECO:0000313|EMBL:CAA9986862.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU01050}; Reference proteome {ECO:0000313|Proteomes:UP000031513}.
FT DOMAIN 103..391
FT /note="Era-type G"
FT /evidence="ECO:0000259|PROSITE:PS51713"
FT REGION 111..118
FT /note="G1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01050"
FT REGION 137..141
FT /note="G2"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01050"
FT REGION 158..161
FT /note="G3"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01050"
FT REGION 218..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 338..341
FT /note="G4"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01050"
FT REGION 368..370
FT /note="G5"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01050"
FT COMPBIAS 237..251
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 499 AA; 56998 MW; 2B100A54E3B63E9B CRC64;
MLKCAGCLFG PLNGKPKCAP HFSARNFSIL ERYIRAKPLS HELKIKEAKN EGINGEGARN
GEARKANEKG ASTYYPPNIT RGVIPKSAYM NTWKLPDQPA NPKYLKIALI GAPNAGKSSL
LNSILNKTIS AVSPKINTTR QDIKGIYTKD NVQLIFIDSP GIVPSHKKKK FCKELVSYAW
KGYEEADLIL FVADTVKRPT HDVFNIVRML APKNVEAYNS ESEDEGETQQ YSFNHPSEDN
DQEEHFEWKG EPQNDLSNGS TSEKLYENSQ KNVQKFVDYF STAMEKEAKY RDKSVKENLL
KNRKKIIQSY NSGVDSKNTT KSEGEQQKLV PPVILVLNKV DLCTNNKWAN ARAKEFMSNG
NFDNIFFISA KYNKGIEELL DYITKFKAKN QFWVYPKDSN TTLTKVQVVE QLINTYLYCW
FNKDVPYKVK HNMLSWCVNL DNSLIIEYQI VVKSQKVAKM ICGVHNKLII NMRRNVSYKL
TQLWGQNVYV HIHVKSVST
//
