ID A0A384KKR6_PLAKH Unreviewed; 577 AA.
AC A0A384KKR6; A0A1A7W0Q5; B3L175;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Polyribonucleotide 5'-hydroxyl-kinase Clp1, putative {ECO:0000313|EMBL:CAA9990194.1};
DE EC=2.7.1.78 {ECO:0000313|EMBL:CAA9990194.1};
GN ORFNames=PKNH_1315600 {ECO:0000313|EMBL:CAA9990194.1};
OS Plasmodium knowlesi (strain H).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=5851 {ECO:0000313|EMBL:CAA9990194.1, ECO:0000313|Proteomes:UP000031513};
RN [1] {ECO:0000313|EMBL:CAA9990194.1, ECO:0000313|Proteomes:UP000031513}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H {ECO:0000313|EMBL:CAA9990194.1,
RC ECO:0000313|Proteomes:UP000031513};
RA Pain A., Boehme U., Berry A.E., Mungall K., Finn R., Jackson A.P.,
RA Mourier T., Mistry J., Pasini E.M., Aslett M., Balasubrammaniam S.,
RA Borgwardt K., Brooks K., Carret C., Carver T.J., Cherevach I.,
RA Chillingworth T., Clarke T.G., Galinski M.R., Hall N., Harper D.,
RA Harris D., Hauser H., Ivens A., Janssen C.S., Keane T., Larke N., Lapp S.,
RA Marti M., Moule S., Meyer I.M., Ormond D., Peters N., Sanders M.,
RA Sanders S., Sergeant T.J., Simmonds M., Smith F., Squares R., Thurston S.,
RA Tivey A.R., Walker D., White B., Zuiderwijk E., Churcher C., Quail M.A.,
RA Cowman A.F., Turner C.M.R., Rajandream M.A., Kocken C.H.M., Thomas A.W.,
RA Newbold C.I., Barrell B.G., Berriman M.;
RT "The genome of Plasmodium knowlesi strain H, a zoonotic malaria parasite
RT with host range from monkey to man.";
RL Nature 455:799-803(2008).
CC -!- SIMILARITY: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
CC {ECO:0000256|ARBA:ARBA00011003}.
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DR EMBL; AM910995; CAA9990194.1; -; Genomic_DNA.
DR RefSeq; XP_002258107.1; XM_002258071.1.
DR AlphaFoldDB; A0A384KKR6; -.
DR STRING; 5851.A0A384KKR6; -.
DR GeneID; 7319495; -.
DR KEGG; pkn:PKNH_1315600; -.
DR VEuPathDB; PlasmoDB:PKNH_1315600; -.
DR InParanoid; A0A384KKR6; -.
DR OMA; CILGVSY; -.
DR OrthoDB; 56092at2759; -.
DR Proteomes; UP000031513; Chromosome 13.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0051734; F:ATP-dependent polynucleotide 5'-hydroxyl-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR Gene3D; 2.60.120.1030; Clp1, DNA binding domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR045116; Clp1/Grc3.
DR InterPro; IPR032324; Clp1_N.
DR InterPro; IPR038239; Clp1_N_sf.
DR InterPro; IPR032319; CLP1_P.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12755; CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P; 1.
DR PANTHER; PTHR12755:SF3; POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9; 1.
DR Pfam; PF16573; CLP1_N; 1.
DR Pfam; PF16575; CLP1_P; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000031513};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CAA9990194.1}.
FT DOMAIN 64..129
FT /note="Clp1 N-terminal beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF16573"
FT DOMAIN 144..304
FT /note="Polyribonucleotide 5'-hydroxyl-kinase Clp1 P-loop"
FT /evidence="ECO:0000259|Pfam:PF16575"
FT REGION 310..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 577 AA; 65583 MW; 10C1BDC120FC0234 CRC64;
MANSGNTRIY HLKAFRELRI VTLEKYAKFE EENEEECVKV RLLPSGSGVG HKNDHNSSGN
FPSTAEIFGR ELIIDKEYKF GCNQKFAIYT FTGCTIQIKG RTLQEYESGN STMKEYLSLS
YTLDAYRKLA KKKKKIGPRV LITGNNNSGK SSVSLILLNY ALKSGFKPIF IEADTKCTCD
KVELNRGPGI MSAFVYDPMN RMKCALDYYF GYLDLNEDIN LYYHLNECIS SCVHLMLLNN
LNSVSSSVKT DGQQEGIYAA GFILNVPSEA DHHVINNLIE IYGINIVIVI DNAFLHYSLK
DQYGDEASRR VADRGRSFAR EGGSDYGRDY EGDYHHDSRH DNRHDTRHDN RHDTLAEGNR
KLNSLPAADE ERKDNKDMDD PVRKVEIVGM PKYEGVIPSD NNRIRYCKNM WYYQYFTKDI
IVTKNLYRRS HIISFKYSLT NFIKLDTNLA VPLSALPADA RDIQRENVTV SLYNGNITNL
TNCILGVSYS QNLNYVHLMN IAAFVHVQSV RLVELEVGED REKSEKGADE TQGNADAQGS
ADTHKDYLIE ILCPLCVTTK NLPPYFVVPG NAKQMKF
//
