ID A0A384KUL3_PLAKH Unreviewed; 1971 AA.
AC A0A384KUL3; A0A1A7VG14; B3LC96;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=poly(A)-specific ribonuclease {ECO:0000256|ARBA:ARBA00012161};
DE EC=3.1.13.4 {ECO:0000256|ARBA:ARBA00012161};
GN ORFNames=PKNH_1429400 {ECO:0000313|EMBL:CAA9990891.1};
OS Plasmodium knowlesi (strain H).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=5851 {ECO:0000313|EMBL:CAA9990891.1, ECO:0000313|Proteomes:UP000031513};
RN [1] {ECO:0000313|EMBL:CAA9990891.1, ECO:0000313|Proteomes:UP000031513}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H {ECO:0000313|EMBL:CAA9990891.1,
RC ECO:0000313|Proteomes:UP000031513};
RA Pain A., Boehme U., Berry A.E., Mungall K., Finn R., Jackson A.P.,
RA Mourier T., Mistry J., Pasini E.M., Aslett M., Balasubrammaniam S.,
RA Borgwardt K., Brooks K., Carret C., Carver T.J., Cherevach I.,
RA Chillingworth T., Clarke T.G., Galinski M.R., Hall N., Harper D.,
RA Harris D., Hauser H., Ivens A., Janssen C.S., Keane T., Larke N., Lapp S.,
RA Marti M., Moule S., Meyer I.M., Ormond D., Peters N., Sanders M.,
RA Sanders S., Sergeant T.J., Simmonds M., Smith F., Squares R., Thurston S.,
RA Tivey A.R., Walker D., White B., Zuiderwijk E., Churcher C., Quail M.A.,
RA Cowman A.F., Turner C.M.R., Rajandream M.A., Kocken C.H.M., Thomas A.W.,
RA Newbold C.I., Barrell B.G., Berriman M.;
RT "The genome of Plasmodium knowlesi strain H, a zoonotic malaria parasite
RT with host range from monkey to man.";
RL Nature 455:799-803(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001663};
CC -!- SIMILARITY: Belongs to the CAF1 family.
CC {ECO:0000256|ARBA:ARBA00008372}.
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DR EMBL; AM910996; CAA9990891.1; -; Genomic_DNA.
DR RefSeq; XP_002262177.1; XM_002262141.1.
DR STRING; 5851.A0A384KUL3; -.
DR GeneID; 7323071; -.
DR KEGG; pkn:PKNH_1429400; -.
DR VEuPathDB; PlasmoDB:PKNH_1429400; -.
DR InParanoid; A0A384KUL3; -.
DR OMA; GLMQNGN; -.
DR OrthoDB; 341493at2759; -.
DR Proteomes; UP000031513; Chromosome 14.
DR GO; GO:0030014; C:CCR4-NOT complex; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004535; F:poly(A)-specific ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006402; P:mRNA catabolic process; IEA:UniProt.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR039637; CNOT7/CNOT8/Pop2.
DR InterPro; IPR006941; RNase_CAF1.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10797; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT; 1.
DR PANTHER; PTHR10797:SF0; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 7; 1.
DR Pfam; PF04857; CAF1; 2.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000031513};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT REGION 479..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 835..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1009..1043
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1082..1101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1120..1153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1213..1316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1410..1455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1488..1570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..561
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..742
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 835..851
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1082..1097
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1121..1153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1255..1272
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1273..1316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1488..1523
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1538..1565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1971 AA; 209143 MW; 445C30B61654884E CRC64;
MDERTKIVDV WANNLEEEFE RIRDVVENHP YVAIDTEFPG IVARPTGNVV DYNYQTIKCN
VDLLKVIQLG VTFSNGKGEL PNVSTWQFNF KFDLESDMYA QNSIDFLKHS GINFEKHQSL
GIELLHFGEI IMSSGLVMNE DVKWISFHGC YDFAYLLKIL TCCALPHNEI AFFDLLNDFF
PSLYDIKYFL LNLNIKQLSR TYSLQKISEI LSVKRIGRQH QAGSDSLVTC KTFFKLLELY
FDNQIDDKKY SGIIYGLGST IKNYNPKLED SPHKINNSNH YGNGYVKGNN NAHGSSGHYG
CGYSSNYDCN YSGSHSVNHS GNHSCNHSCN HSGNHSCNHS CNHSGNHSDN NDSEERSREC
NHMYMDGNNC MMHTQNHMLT SYQGNKEYQI SFSKDAVKGN FKSDMLYNLY ADMNQNNYNT
IANVGNMIQN NINGFASYEN DATNNRDFIK YSSQPQLLNM STANAKSLRV LANSDVHTNS
LSGGDSGSNS ANGNGSGNGS GNGSRNGSGN GSGNGSRNGS GNGSRNGSGN GSRNGSGNGR
GNGSRNGSGN GSGNGRGNGR ASGKNSGKGG GKGDNKGEGK GNAKNSNKNN NKNNGKNNSN
GDGNSKNGSN SRGNNGGNNG GNNEGNNGGS SGGNTGGNGT GHSGGHGGGQ NSGHNGGNGN
SHTNGHSGGN GNNHGNNKGN GKNKYNNNTS NNTNINNNGR DFISLAGNSN KSSLDNSTKP
LKNVFNDLPK RPSNDNLNND NWRNDNLSSD NWRSDNFRND NLSDHFSTAN VNSSSEPLRN
MNGVGGTTNR NFTNPSGNII SLNSANMSVS SMKNSILLNN LSSLSGTNSN VSISGKSGLS
SKGSMQSKKG AIGKNGSVGK NNVVGLSMSS LNNPVVLPNG LSVGTTGINL ANINNGMVVN
NMDVNNMRMN NLSSNVSVNR VPAANVGNIN LKQSSISVSM NNRNANNSCS VSTVSEVNGR
QSGSMKSVNI SEESIIDAVK GDYEVDNSNP MPQNGIALSS MYVPNMNYAN GGGNGNHKNS
ASANGSGKNS SKKNNSSNGS DIGPFLNSVN LGAANMASNP PLQMNSNVSN FKQYPMPNKY
NSFSNYPTSV SNPNDKGTTE DSEIDEALFD GAGGMGIVGN GINSGSGNGH GNGHGNGNGN
VGNSGANANG KNALNKNGMN KVNMAHISYG KNIIPSGVNG NSNFKGSHKS NTLMNSEMPG
GLMQNGNLIS KNNELSSGNF DAMSDLPPNM TMLRDDNSKD EKMNNLNKGA MGSFPVKHPP
PPPPPPPPPS SCNLTNVMSN GNQNNSGEKA KNNSIMKNLS SSSSNNTGNA NLSNGAHPIS
GNEAKICNLG MGSASYTSNH LLKHNMSLSN LGNVSGSNKL NLANMANPNS SGVIKNNSPG
PVGPAGANGG VRALGTNIVP VYNATNKGPL DNGEANMNPS FNMNGSNKNN KNCNQLSSTT
NERNSKNNAK EGNGKNTVLL VNSSVSEEAY NVDEGIIANG GTLSSANSLY NGSPKNSGDQ
AKGRTNTNTT SDSANNGKNG KGGKNGNKNH KHSKNKNKGA NGGINIGGVT NATTANGGST
VIKKRSNEKN AADKMNISNL EQNNNYDSVS QKKNGNKIFA NIVREEEEGK FSSGNVVSND
EKKNAPIDRN EHKSLLNNMN YFKGDNVKMY NRGGIGAGSG AAPVAGPYGK NGAHHLGVKN
NFLNSPTCDS ESMLHNISSV NIINDMNTSD IMNPSNVQNY ANSGSASDVN ADIHYLGSMN
NSKGGNNYAE VLHGKMNNLN IMNISKMHSG TYSVNNNVGP LSGGLGGRHN GKHNSSSIAE
NTSTNGGAFN FVNKKTSKDN LSMINHAMMN NLNLNNIYAN SDTKAFNKMN VNHKGGGSVS
NSNFCFNGEG ATGVVARNQP YYNSYAESFP DKITNKSFIE KSGNIIPSSI YNGKREEPSI
SMYNYVDSNN FLEKNAILAD KYEPMESPQG NMFNYASYEY KNKERKFFYD A
//
