ID A0A384LQJ1_PLAKH Unreviewed; 472 AA.
AC A0A384LQJ1; A0A1A7W4L8; B3L7G0;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Sphingomyelin synthase 1, putative {ECO:0000313|EMBL:CAA9989080.1};
DE EC=2.7.8.27 {ECO:0000313|EMBL:CAA9989080.1};
GN ORFNames=PKNH_1125200 {ECO:0000313|EMBL:CAA9989080.1};
OS Plasmodium knowlesi (strain H).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=5851 {ECO:0000313|EMBL:CAA9989080.1, ECO:0000313|Proteomes:UP000031513};
RN [1] {ECO:0000313|EMBL:CAA9989080.1, ECO:0000313|Proteomes:UP000031513}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H {ECO:0000313|EMBL:CAA9989080.1,
RC ECO:0000313|Proteomes:UP000031513};
RA Pain A., Boehme U., Berry A.E., Mungall K., Finn R., Jackson A.P.,
RA Mourier T., Mistry J., Pasini E.M., Aslett M., Balasubrammaniam S.,
RA Borgwardt K., Brooks K., Carret C., Carver T.J., Cherevach I.,
RA Chillingworth T., Clarke T.G., Galinski M.R., Hall N., Harper D.,
RA Harris D., Hauser H., Ivens A., Janssen C.S., Keane T., Larke N., Lapp S.,
RA Marti M., Moule S., Meyer I.M., Ormond D., Peters N., Sanders M.,
RA Sanders S., Sergeant T.J., Simmonds M., Smith F., Squares R., Thurston S.,
RA Tivey A.R., Walker D., White B., Zuiderwijk E., Churcher C., Quail M.A.,
RA Cowman A.F., Turner C.M.R., Rajandream M.A., Kocken C.H.M., Thomas A.W.,
RA Newbold C.I., Barrell B.G., Berriman M.;
RT "The genome of Plasmodium knowlesi strain H, a zoonotic malaria parasite
RT with host range from monkey to man.";
RL Nature 455:799-803(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sphingomyelin synthase family.
CC {ECO:0000256|ARBA:ARBA00005441}.
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DR EMBL; AM910993; CAA9989080.1; -; Genomic_DNA.
DR RefSeq; XP_002261428.1; XM_002261392.1.
DR AlphaFoldDB; A0A384LQJ1; -.
DR GeneID; 7321544; -.
DR KEGG; pkn:PKNH_1125200; -.
DR VEuPathDB; PlasmoDB:PKNH_1125200; -.
DR InParanoid; A0A384LQJ1; -.
DR OMA; YECTDLI; -.
DR OrthoDB; 592349at2759; -.
DR Proteomes; UP000031513; Chromosome 11.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033188; F:sphingomyelin synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd01610; PAP2_like; 1.
DR Gene3D; 1.20.144.10; Phosphatidic acid phosphatase type 2/haloperoxidase; 1.
DR InterPro; IPR045221; Sphingomyelin_synth-like.
DR InterPro; IPR025749; Sphingomyelin_synth-like_dom.
DR PANTHER; PTHR21290:SF65; PHOSPHATIDYLINOSITOL:CERAMIDE INOSITOLPHOSPHOTRANSFERASE; 1.
DR PANTHER; PTHR21290; SPHINGOMYELIN SYNTHETASE; 1.
DR Pfam; PF14360; PAP2_C; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000031513};
KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CAA9989080.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 137..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 276..346
FT /note="Sphingomyelin synthase-like"
FT /evidence="ECO:0000259|Pfam:PF14360"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..43
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 472 AA; 54556 MW; 946457C8325099AB CRC64;
MIEGKLNSRP PSDGSKKPSS KYKAGKGRQS RKESEGKNLE QKEDMQSAID YKNNLNTECV
GTLNSKFIDD RDGDNNQTDA FSYKKESMMR ASQSTHFGMQ DDFILEDIDD SFEERENSIN
IVEVKSSSAK RKMLKTLYIR LIYALLYTIF GILIQCYFII LSDTYYKTGD EPLKDRVHEL
YKEVPSFMKA AFINSNIMFF LIITLLRFGL FSPILISISM FIRLLLMLSS IYCVRSIFIY
VTTIPCPIPT CQPVRNKNLL ENLYTTYLII TAQVYECTDL IISGHTAFTT VLKFFWMFYE
KKIYIKAVLF LYCLFIYGMI VISRFHYTVD VLMGYVFGST VFLFYHCLLE IAAKRYAKHG
SFSIKNSNYA ASFVERCAVF TYFIQIIGFM EGLEHRLNMA ASYDKEWNCF CPCKPVNAKG
LIIKKRTMNN EEYCDFSDHF YHSYAGSGSF DLSTLKNIAN GIKRLCGIKK KN
//
