ID A0A385C7G3_9GAMM Unreviewed; 55 AA.
AC A0A385C7G3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=DNA gyrase inhibitor YacG {ECO:0000256|HAMAP-Rule:MF_00649};
GN Name=yacG {ECO:0000256|HAMAP-Rule:MF_00649,
GN ECO:0000313|EMBL:AXQ23647.1};
GN ORFNames=BEN71_16920 {ECO:0000313|EMBL:AXQ23647.1}, CDG68_19825
GN {ECO:0000313|EMBL:AYO55754.1}, EXU28_11320
GN {ECO:0000313|EMBL:RZG45799.1};
OS Acinetobacter wuhouensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter.
OX NCBI_TaxID=1879050 {ECO:0000313|EMBL:AXQ23647.1, ECO:0000313|Proteomes:UP000257257};
RN [1] {ECO:0000313|EMBL:AXQ23647.1, ECO:0000313|Proteomes:UP000257257}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WCHA60 {ECO:0000313|EMBL:AXQ23647.1,
RC ECO:0000313|Proteomes:UP000257257};
RX PubMed=30117799; DOI=10.1099/ijsem.0.002963;
RA Hu Y., Feng Y., Qin J., Radolfova-Krizova L., Maixnerova M., Zhang X.,
RA Nemec A., Zong Z.;
RT "Acinetobacter wuhouensis sp. nov., isolated from hospital sewage.";
RL Int. J. Syst. Evol. Microbiol. 68:3212-3216(2018).
RN [2] {ECO:0000313|EMBL:AYO55754.1, ECO:0000313|Proteomes:UP000279962}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WCHAW010062 {ECO:0000313|EMBL:AYO55754.1,
RC ECO:0000313|Proteomes:UP000279962};
RA Hu Y., Long H., Feng Y., Zong Z.;
RT "The complete genome of Acinetobacter wuhouensis strain WCHAW010062.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:RZG45799.1, ECO:0000313|Proteomes:UP000293863}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WCHAW060049 {ECO:0000313|EMBL:RZG45799.1,
RC ECO:0000313|Proteomes:UP000293863};
RA Qin J., Hu Y., Ye H., Wei L., Feng Y., Zong Z.;
RT "The Batch Genome Submission of Acinetobacter spp. strains.";
RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Inhibits all the catalytic activities of DNA gyrase by
CC preventing its interaction with DNA. Acts by binding directly to the C-
CC terminal domain of GyrB, which probably disrupts DNA binding by the
CC gyrase. {ECO:0000256|HAMAP-Rule:MF_00649}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00649};
CC Note=Binds 1 zinc ion. {ECO:0000256|HAMAP-Rule:MF_00649};
CC -!- SUBUNIT: Interacts with GyrB. {ECO:0000256|HAMAP-Rule:MF_00649}.
CC -!- SIMILARITY: Belongs to the DNA gyrase inhibitor YacG family.
CC {ECO:0000256|HAMAP-Rule:MF_00649}.
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DR EMBL; CP031716; AXQ23647.1; -; Genomic_DNA.
DR EMBL; CP033133; AYO55754.1; -; Genomic_DNA.
DR EMBL; SGSQ01000016; RZG45799.1; -; Genomic_DNA.
DR RefSeq; WP_068975276.1; NZ_SGSR01000028.1.
DR AlphaFoldDB; A0A385C7G3; -.
DR STRING; 1879050.GCA_001696605_02689; -.
DR KEGG; awu:BEN71_16920; -.
DR OrthoDB; 9809663at2; -.
DR Proteomes; UP000257257; Chromosome.
DR Proteomes; UP000279962; Chromosome.
DR Proteomes; UP000293863; Unassembled WGS sequence.
DR GO; GO:0008657; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR HAMAP; MF_00649; DNA_gyrase_inhibitor_YacG; 1.
DR InterPro; IPR005584; DNA_gyrase_inhibitor_YacG.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR36150; DNA GYRASE INHIBITOR YACG; 1.
DR PANTHER; PTHR36150:SF1; DNA GYRASE INHIBITOR YACG; 1.
DR Pfam; PF03884; YacG; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW Rule:MF_00649};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|HAMAP-Rule:MF_00649}.
FT BINDING 7
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00649"
FT BINDING 10
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00649"
FT BINDING 25
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00649"
FT BINDING 29
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00649"
SQ SEQUENCE 55 AA; 6325 MW; F07CF55CD475C0F9 CRC64;
MPKSFPCPRC GEATTWENNE FRPFCSDRCK LIDLGAWANE DYKLPTEDSP PEEDS
//
