ID A0A385C8V3_9GAMM Unreviewed; 935 AA.
AC A0A385C8V3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=BEN71_16025 {ECO:0000313|EMBL:AXQ23483.1}, CDG68_18885
GN {ECO:0000313|EMBL:AYO55585.1};
OS Acinetobacter wuhouensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter.
OX NCBI_TaxID=1879050 {ECO:0000313|EMBL:AXQ23483.1, ECO:0000313|Proteomes:UP000257257};
RN [1] {ECO:0000313|EMBL:AXQ23483.1, ECO:0000313|Proteomes:UP000257257}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WCHA60 {ECO:0000313|EMBL:AXQ23483.1,
RC ECO:0000313|Proteomes:UP000257257};
RX PubMed=30117799; DOI=10.1099/ijsem.0.002963;
RA Hu Y., Feng Y., Qin J., Radolfova-Krizova L., Maixnerova M., Zhang X.,
RA Nemec A., Zong Z.;
RT "Acinetobacter wuhouensis sp. nov., isolated from hospital sewage.";
RL Int. J. Syst. Evol. Microbiol. 68:3212-3216(2018).
RN [2] {ECO:0000313|EMBL:AYO55585.1, ECO:0000313|Proteomes:UP000279962}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WCHAW010062 {ECO:0000313|EMBL:AYO55585.1,
RC ECO:0000313|Proteomes:UP000279962};
RA Hu Y., Long H., Feng Y., Zong Z.;
RT "The complete genome of Acinetobacter wuhouensis strain WCHAW010062.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP031716; AXQ23483.1; -; Genomic_DNA.
DR EMBL; CP033133; AYO55585.1; -; Genomic_DNA.
DR RefSeq; WP_068973280.1; NZ_SGSR01000024.1.
DR AlphaFoldDB; A0A385C8V3; -.
DR STRING; 1879050.GCA_001696605_00572; -.
DR KEGG; awu:BEN71_16025; -.
DR OrthoDB; 9797243at2; -.
DR Proteomes; UP000257257; Chromosome.
DR Proteomes; UP000279962; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 1.20.120.160; HPT domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR036641; HPT_dom_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR008207; Sig_transdc_His_kin_Hpt_dom.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR45339; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J; 1.
DR PANTHER; PTHR45339:SF6; RESPONSE REGULATORY DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF01627; Hpt; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00073; HPT; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF47226; Histidine-containing phosphotransfer domain, HPT domain; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50894; HPT; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinase {ECO:0000313|EMBL:AXQ23483.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Transferase {ECO:0000313|EMBL:AXQ23483.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 171..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 296..523
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 666..791
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT DOMAIN 829..929
FT /note="HPt"
FT /evidence="ECO:0000259|PROSITE:PS50894"
FT MOD_RES 721
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
FT MOD_RES 868
FT /note="Phosphohistidine"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00110"
SQ SEQUENCE 935 AA; 106579 MW; BEA4349FF645C0DC CRC64;
MSNFNKKLFK RLKLNHAYGQ LIALIFVPIM VLACVGTALV LSETSSAAKS KQRFQAIAIL
SRYQYTAEKL TAVMEINKTQ HIKAENILQK MFNEKHLLSA AVIDANNINH LSIGYQSKRT
WPQIPKSGTF FGPIQSKTNN IYGIKLNPIN STENMWLVIE MDNQPLEIAH YRVMIVLITT
ALFTLLLLLL CLNFYSRRWI APMYEIRMQL QRLNADTLDQ HMVINSTGEL RLLQRDIANV
VKRLHFSFLE LKEHTEQTED DLRRTLDTLE VQNITYKQAR DQAILSNQSK SVFLANISHE
LRTPLNSIDG FIHLMLRQDN LSNDQSLYLQ TIRKSSAHLL ALINDVLDFS KIDAGKLELE
TAPFDLEEAI FDVMDMLSPL AAQKHIEMAF YFADNVPKYV IGDALRFKQI LTNLISNAIK
FTPDGEIIVR ARMEHDDIGQ CLLHFSVQDS GIGLSGTDRK KLFESFSQGD ASVTRQFGGT
GLGLAISKQL VHLMHGQIGF EDNQERAPTE KGSTFWFTAM LAVNEDEDIV HPSFSEQKVV
SYLAHPATAN VLRHYLEDYQ VQHNEAQSIL DLFSRLNSLG QDTDNTWLIV DHSGDTEALL
KEIRGRYQGH LAVYGYQMSL DPNMLSEYKA RPLYQPLSRS SVIQLLSNKP VFEQEQHKDF
KGQDLHILAV DDHLPNLIVL EALLGELNVK TTKAQSGQEA LTIIQQGIEQ GSKPYDLVFM
DIQMPVMSGI DTTRAIRSLE STLDGMRMPI IALTAHALAD EKQKLLKVGM DDYVTKPIQI
EQIIQILTNW TSDKFIQQKQ QTNENKVYIE AFNTDILDWK QSLALAANKE DLAQDLLKML
VDSFPTELDE IEQLIELEDF PQLEHVLHRL YGATRYVGTP KLQRVTGEFE QFISTLRKER
RKADENFIQE VLRRLDDLQV AIREVETAAQ QILPN
//
