ID A0A386ZFC6_9NOCA Unreviewed; 997 AA.
AC A0A386ZFC6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316, ECO:0000256|HAMAP-Rule:MF_00205};
DE Short=UvrA protein {ECO:0000256|HAMAP-Rule:MF_00205};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156, ECO:0000256|HAMAP-Rule:MF_00205};
GN Name=uvrA {ECO:0000256|HAMAP-Rule:MF_00205,
GN ECO:0000313|EMBL:AYF76127.1};
GN ORFNames=D7D52_22365 {ECO:0000313|EMBL:AYF76127.1};
OS Nocardia yunnanensis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=2382165 {ECO:0000313|EMBL:AYF76127.1, ECO:0000313|Proteomes:UP000267164};
RN [1] {ECO:0000313|EMBL:AYF76127.1, ECO:0000313|Proteomes:UP000267164}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFHS0054 {ECO:0000313|EMBL:AYF76127.1,
RC ECO:0000313|Proteomes:UP000267164};
RA Zhang J.;
RT "Nocardia yunnanensis sp. nov., an actinomycete isolated from a soil
RT sample.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC scans DNA for abnormalities. When the presence of a lesion has been
CC verified by UvrB, the UvrA molecules dissociate. {ECO:0000256|HAMAP-
CC Rule:MF_00205}.
CC -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC lesions. {ECO:0000256|HAMAP-Rule:MF_00205}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_00205}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000256|ARBA:ARBA00038000, ECO:0000256|HAMAP-Rule:MF_00205}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_00205}.
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DR EMBL; CP032568; AYF76127.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A386ZFC6; -.
DR OrthoDB; 9809851at2; -.
DR Proteomes; UP000267164; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd03270; ABC_UvrA_I; 1.
DR CDD; cd03271; ABC_UvrA_II; 1.
DR Gene3D; 3.30.190.20; -; 1.
DR Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 1.
DR Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR HAMAP; MF_00205; UvrA; 1.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR NCBIfam; TIGR00630; uvra; 1.
DR PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR PANTHER; PTHR43152:SF3; UVRABC SYSTEM PROTEIN A; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00205};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|HAMAP-Rule:MF_00205};
KW SOS response {ECO:0000256|HAMAP-Rule:MF_00205};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|HAMAP-Rule:MF_00205};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|HAMAP-
KW Rule:MF_00205}.
FT DOMAIN 618..946
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT ZN_FING 749..775
FT /note="C4-type"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00205"
FT REGION 957..997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 32..39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00205"
FT BINDING 650..657
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00205"
SQ SEQUENCE 997 AA; 108864 MW; E090AF90B2450F79 CRC64;
MADRLTVRGA REHNLKGVDL DLPRDSLIVF TGLSGSGKSS LAFDTIFAEG QRRYVESLSA
YARQFLGQMD KPDVDFIEGL SPAVSIDQKS TNRNPRSTVG TITEVYDYLR LLFARAGTPH
CPVCGELIAK QTPQQIVDQV LAMPEGTKFQ VLAPVVRTRK GEFVDLFESL NSQGYSRVRV
DGVVHPLTDP PKLKKQEKHD VEVVVDRLSV KPSSKQRLTD SIETALRLAD GIVVLDFVDR
DEHAHDRERR FSERLACPNG HPLDIEDLEP RSFSFNSPYG ACPDCTGLGI RKEVDPDLVV
PDPELSLNEG AIAPWSRGQT AEYFTRLLSG LAEALGFSMD TPWNQLPLKA RKAVLEGSSE
QVHVSYTNRY GRKRSYYADF EGVMPFLQRR MDATESESMK EHYDGYMRDI PCPVCNGARL
RPEILAVTLS AGDQRRSIAD LSDLSIGEAA KFLNTLTLDE RQAAIAAQVI KEIQARLGFL
LDVGLQYLTL SRAAATLSGG EAQRIRLATQ IGSGLVGVLY VLDEPSIGLH QRDNRRLIET
LTRLKNLGNT LIVVEHDEDT IHASDWVVDI GPLAGEHGGQ VVYSGPYEGL LKDKQSLTGA
YLSGREQIEV PLVRRPIDKR KQLTVVGAVE HNLRDIDVSF PLGVLTSITG VSGSGKSTLV
NDILATVLQN KLNGARQVPG RHTRVNGLDH LDKLVQVDQS PIGRTPRSNP ATYTGVFDKI
RTLFAATTEA KVRGYQPGRF SFNVKGGRCE ACSGDGTLKI EMNFLPDVYV PCEVCHGARY
NRETLEVHYK GKTIAEVLDM PIEEAAEFFE PVTSIHRYLK TLVDVGLGYV RLGQSAPTLS
GGEAQRVKLA AELQKRSTGR TIYILDEPTT GLHFEDIRKL LTVINGLVDK GNSVIVIEHN
LDVIKTSDWV IDMGPEGGSG GGTVIAEGTP EDVAAVADSY TGQFLKDVLS AAPAAAPAPA
KKAAKKAPAK KAAPKTDAQA AAAKKATAAR RKAAALR
//
