ID A0A386ZGT2_9NOCA Unreviewed; 4455 AA.
AC A0A386ZGT2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:AYF76324.1};
GN ORFNames=D7D52_23650 {ECO:0000313|EMBL:AYF76324.1};
OS Nocardia yunnanensis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=2382165 {ECO:0000313|EMBL:AYF76324.1, ECO:0000313|Proteomes:UP000267164};
RN [1] {ECO:0000313|EMBL:AYF76324.1, ECO:0000313|Proteomes:UP000267164}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFHS0054 {ECO:0000313|EMBL:AYF76324.1,
RC ECO:0000313|Proteomes:UP000267164};
RA Zhang J.;
RT "Nocardia yunnanensis sp. nov., an actinomycete isolated from a soil
RT sample.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP032568; AYF76324.1; -; Genomic_DNA.
DR OrthoDB; 5475787at2; -.
DR UniPathway; UPA00011; -.
DR Proteomes; UP000267164; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd19540; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 3.
DR Pfam; PF00668; Condensation; 5.
DR Pfam; PF00550; PP-binding; 4.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 4.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 10.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 999..1073
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2518..2593
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3560..3635
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4120..4195
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4455 AA; 472323 MW; D89043E5368BE1A5 CRC64;
MTRELEAARA ATTLSENATN PTERSFPLTP AQSGMWLAQQ LDPAVPLLEA QYIEMRGPLD
VALLRRVAAQ AGREFGSGVL RFVEVDGEPR QIVESGREPV IGFLDFRDRA DPVSHALEWM
RGDVAAPIDM LGELTGISTV IRVGESHHLW YTRAHHILID GFGSVTMLYR VAELYNAAVR
GQTAPPGTAA SLWEVYEAER AYRESTRYAA DAEYWRTAAA GLPESCSLVP GTAPASALAR
EARAELGAVT AARLEAAARR FDSSAAGVVM AALALYYARL TATEDVVLSL PVSGRTTAML
RRSGGMIANV VPLRVPVPRA ARVGDVLDAV RVAASGALRH QRFRYEDMRI EARGADGAVD
ASPTQPGRGM VGPVVNIMLF PAGIDFAGVE SSLHVLTSGP IEDLFVNFYQ HGAGAPIHVD
FAANPRLYDE DSLSRHHRRF LAVLDSLLDA EVEAPVADLN YVLADEKSLL AGAQGPLAPP
PRLLSEILAA GMLRAGSDAV AVVSGARRLT YGELDALSNR LARRMLRATA EDGAGVSTSI
GPESTVLLAL PRSIEAVVAL WAVAKTGAAF VPLGTALPAE RVERIAAEAG AVLGLTLAEF
GAALPDSVRW LPLDGLVRDE TLSMGRVEDT DGPLTPAELS GRTRVENPAY VVFTSGSTGV
PKGVVVTHAG LAGLADAIVR AYRVEADARV LQCLNPSFDA AVLEWLMAFA AGATLVVAEQ
DPVVGAELTG LIRYHGITQV CSTPAVLATL ESGALDGVRA VSSGGEPTPP DIVARFGIGR
ELLNSYGPSE TTVAVTYTTG LVPGRDAGIG DPIPGAGMQV LDRLLRPVPI GMAGELYVTG
PGVARGYAGR PGLTAERFVP VPSGPAGARM YRTGDLVRWN ESGVLDYVGR GDFQVKLRGM
RIELGEIDAA LDTHPGVEIA VTVARPAPSG GTVLAAYVVP QPGHAVTERE LIDHVAHRLP
PYMVPATVTV LGALPLTANG KVDRRALPEP VVAQSVSRAA GSEAERVLCA LFGEVLGTGE
VGPDTSFFAL GGDSIMAITL VSRARATGLV FSAREVFEHR TPAALAAVVT RVEDRPRRLP
ELPGGGVGRM PLTPVAAWLV RRPGWQHFAQ SMVVRVPVGA ESRALVRTLQ ALLDRHDMLR
ARVVETEEGL QLEVPPVDST DVAELISRID CTTTPSGADI SESAIDDALP AAVDRLDPLS
GVMFSATWLD GGTERSGRLA IVIHHLACDA VSWRILLPDL MSAWSAISAG AQPSLDDTGT
SVRTWAYTLA ELATAVHEFE YWREVLAADT LLGRRRLDEQ VDTHRTAGRI EVEVPQAVSA
TLLSRLATTY RCGVEDALLA ALTVALARGE STATGGETVV MVERHGRDEV AVPGADLSRT
VGWFTAQVPV RLRPVGLAEA ALKVVKERLR SVPRGGFGYG LLRYSNAVTE RELAALPTPQ
VGFNYLGQVP DAAVTGDWLP VSMASRLGGH ADPDMPLAAV VSIDAVTLES ERGPRIRAMW
QFASEAIAAE AVESLTREWL SAIEEIAELI ARPDAGGLTP GDLPLLTVSQ AEIDGWERRF
GRLTDVWPMT PLQRGLLFQS QLAEGGSDGY SVQAVIDIEA DLDPDRLTAA AQALVCRHDV
LRAGFVASDS SAVQVIPADV AVPCAYREAF DATPEQLDAI AAEEFAVPFA VDAPPLIRFL
CVAAGKRRYR LIITNHHLIL DGWSMPLLFA ELLGLYETAG DDAGFAVPVP FRTHLEWLAA
RDARRAHTAW SEALAGLDGP TLIAPTAPRA GAPTTPVAHE VPLPAELPDA LRRTAAAHQV
TVNTLVQVAW ALLLCEQTGG TDIVFGATVS GRPPELTGSD RMVGMLVNTV PVRISLDPGE
TVGDLLSRVQ REQAALAEHQ HVGLDEIQSI TGLGPLFDTA TVFESYPVDA AALTAATRQA
ALTVTGMRAQ DGTHYPLSLA AYANNGLRLE LTRSPRYFDA PAADALVAAL SRLLIALTGD
SSRRAAQLTG TPADAGTAVR AGAPSGGVRL LPDLLSANGS PSAVAVLGWL EPSAVGDIET
SQTIQLTYGE LDAASSRLAR RLIDAGAKPE TAVLVALPRS IDAMIAVWAI AKTGAAFVPV
DVTQPAARTA AIAAESGAVL GITDAAFHSE SNPLPAGVQW LRMGDPGLAA ACAGLSDAPV
TDAERLAPLR AEQAAYVVFT SGSTGTPKGV VVSHTGLADM VAAMGTRGGV AQGSRVMHCL
NPAFDAAMLV WMSAFAAGAT VVVAPPEANA GADLAAAIRA GAATHLTCTP SVLATLDVDD
LRRVRTVVLG GEPCPPGLVS RLGPGRALVN SYGPAETTIA ASFGDPMTGA TAALLGTPVP
GTTFLVLDGW LRPVPPGAVG GLYVRGPGLA RGYAGRAALS ASRFVADPFS EGRRLYRTGD
LMRCTAAGFE YVGRGDFQVK IRGIRVEPGE VDAVLTTHPR VDGAVTVARR NQAGAMTLCS
YAAGETTAAE LLAWASDRLP RYLVPASLQM LPELPLTSSG KVDLRALPEP VLAQAEYVAP
AGDEAAIAAA YAKVLGLDRV GARDDFFALG GDSLIAARVA ARLSADLGRT VPVRLLFEAP
VVAELAGRLS GADTPRSGPA LVRRDHTGLV PLSPAQQRMW FVNRYDPTSP AYNVPVALRL
SGHPDTTALR RALRDVIDRH ETLRTVYPDV DGVGMQQVLP AEDVPLDLDP RPVTGDRLAS
AVAEVIGTGF DVTAAVPVRL RLFRVESTTV DTDPEHVIVL VVHHIATDGF SMAPLTRDVA
AAYATRAAGV SPAWEPLPVQ YADYALWQRD RLGADDDPTS LGAQQTDYWK QVLAGIPDHL
ELPTDRPRPA QATHHAAEHV ARVDTRLAAA IERRAREHRA TPFMVVHAAL AVLLSRLAGT
GDVVIGTPVA GRGERELDDL VGMFVNTLVL RTGIRPEEDF GALLDRVRDT DLAAFERADV
PFERLVEVLA PARSPARHPL VQVMLVFQNL ALPELRLPDL TVSPLELPQT SSRFDLSVTV
VGDTDGMELR CCYATDLFDA STAAAFTDRL LRVLDDGTAE TSTPIGDLDL LTHGERQRMH
RTEPPVAAPR TLADLMADAV ATNPEGVAVV CGDRALTYRE LDDRAERLAR RLAAAGAGPE
TLVAVGIPRS IESVLAVWAV ARTGAAFVPV DPAYPPDRIA RIIDVSGACL GLTVATHRDR
LPTTVDWWCL DEHDEQTTPA FLHEIVRDTA HPAYVIFTSG STGAPKGVMV THAGLANLAI
AQRDRDHITS QSRVLHVASP SFDASVVELL MAVGAAATLV IAPPTVFAGP ELRELLSRHR
VSHIALTPSA LATVDPGGLD DLRLIVTGGE PCPPELVAAW AAQGRSHFND YGPTEATVWA
AGAALHPGEP ITIGRPAPGA RALVLDDRLR PVPDGVVGEL YLSGIALARG YFGRFDLTAA
RFVADPHGHG QRMYRTGDLV RRRHGDLEYL GRTDTQVKLR GLRIELGDVE AALTAEPAVA
RAVATVRDDG HGGLLAAYVV AAPGSQLEPA ALKKAAAQRL PSYMVPSAIT VLPELPRTAN
GKLDLDRLPA PQPMTGDRQP PDGPVETAVA AAFAEVLGLD TVWRGDDFFA LGGNSLIATQ
VVARLGATLD TAVPVRALFD APTVSELAAL VAAGDASGRP RPGPRPRPDH IPLSAAQQRM
WFLNRYDPGS PLYNIPGAFE IAGALDISVL RTAIDDVVAR HETLRTIYPL GADGRPEQRI
LSPATDSTPI TELDVTADEL GSALIAELSV GFDITRETPL RVCVLHVEPE RTVLALAVHH
IAADGWSMAP LARDVMYAFA ARTTGVAPEW SPLPLQYADY ALWQQELLGS DHDPDSLANR
QLDFWRTTLA GLPDMHALPT DRPRPTVPSG TGDRIEFSVP AEVHDRVQLL AREHGASPFM
VVHAALAVLL ARLSGQPDIA IGSVVAGRGD GEFDDLVGMF VNTVVLRSHI DPAAGFADTL
DAVRHADLAV YGNMDLPFER LVEALAPARS TDHHPLFQVL LAFQNVRTEA TTLPGLTIRP
LDAPAPGAKF DLEWMLAEQF GAMGEPAGMT ASLTFATDLF DRGSAAAMVD GFRTLLDAMT
ADPLAGVGAI GGPHPPALTV NPHAAPSAPV RERVRRVYRA PRTDAERTLV TAFESVLDSP
RVGVDDNFFD IGGNSMGAVR LVTEVRDTTG IPMPLQWMFL DPTPAALARR LVETAAQPDV
DPAMRVLLPM RPQGEGPALF CVHPAIGLAW CYGGLVQYID GAHPIYGIQS PGVTDGGTAD
RTVHDLAVRY VEEIRRVQPE GPYHLLGYSA GGPLAHAMAV ELRRRGAPVP SLIMIDSRAD
VAVPDDSAIP PLSLLLAEFG GIDVPPELEH LTAAQAAELL EASGISFTAT ELEHFYGDLR
HLLRQIAAHD HEVFDGDLLF FAAAYNPDPN PNVTTWRPYI SGAIHDRPLP YGHNEMITAE
ALAIIGPLVD AYLKR
//