ID   A0A386ZGT2_9NOCA        Unreviewed;      4455 AA.
AC   A0A386ZGT2;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:AYF76324.1};
GN   ORFNames=D7D52_23650 {ECO:0000313|EMBL:AYF76324.1};
OS   Nocardia yunnanensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Nocardia.
OX   NCBI_TaxID=2382165 {ECO:0000313|EMBL:AYF76324.1, ECO:0000313|Proteomes:UP000267164};
RN   [1] {ECO:0000313|EMBL:AYF76324.1, ECO:0000313|Proteomes:UP000267164}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFHS0054 {ECO:0000313|EMBL:AYF76324.1,
RC   ECO:0000313|Proteomes:UP000267164};
RA   Zhang J.;
RT   "Nocardia yunnanensis sp. nov., an actinomycete isolated from a soil
RT   sample.";
RL   Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR   EMBL; CP032568; AYF76324.1; -; Genomic_DNA.
DR   OrthoDB; 5475787at2; -.
DR   UniPathway; UPA00011; -.
DR   Proteomes; UP000267164; Chromosome.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd05930; A_NRPS; 1.
DR   CDD; cd19540; LCL_NRPS-like; 2.
DR   Gene3D; 3.30.300.30; -; 3.
DR   Gene3D; 3.40.50.980; -; 2.
DR   Gene3D; 1.10.1200.10; ACP-like; 3.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR010060; NRPS_synth.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR001031; Thioesterase.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR   NCBIfam; TIGR01720; NRPS-para261; 1.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 3.
DR   Pfam; PF13193; AMP-binding_C; 3.
DR   Pfam; PF00668; Condensation; 5.
DR   Pfam; PF00550; PP-binding; 4.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00823; PKS_PP; 4.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR   SUPFAM; SSF47336; ACP-like; 4.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 10.
DR   PROSITE; PS00455; AMP_BINDING; 3.
DR   PROSITE; PS50075; CARRIER; 4.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT   DOMAIN          999..1073
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2518..2593
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          3560..3635
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          4120..4195
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   4455 AA;  472323 MW;  D89043E5368BE1A5 CRC64;
     MTRELEAARA ATTLSENATN PTERSFPLTP AQSGMWLAQQ LDPAVPLLEA QYIEMRGPLD
     VALLRRVAAQ AGREFGSGVL RFVEVDGEPR QIVESGREPV IGFLDFRDRA DPVSHALEWM
     RGDVAAPIDM LGELTGISTV IRVGESHHLW YTRAHHILID GFGSVTMLYR VAELYNAAVR
     GQTAPPGTAA SLWEVYEAER AYRESTRYAA DAEYWRTAAA GLPESCSLVP GTAPASALAR
     EARAELGAVT AARLEAAARR FDSSAAGVVM AALALYYARL TATEDVVLSL PVSGRTTAML
     RRSGGMIANV VPLRVPVPRA ARVGDVLDAV RVAASGALRH QRFRYEDMRI EARGADGAVD
     ASPTQPGRGM VGPVVNIMLF PAGIDFAGVE SSLHVLTSGP IEDLFVNFYQ HGAGAPIHVD
     FAANPRLYDE DSLSRHHRRF LAVLDSLLDA EVEAPVADLN YVLADEKSLL AGAQGPLAPP
     PRLLSEILAA GMLRAGSDAV AVVSGARRLT YGELDALSNR LARRMLRATA EDGAGVSTSI
     GPESTVLLAL PRSIEAVVAL WAVAKTGAAF VPLGTALPAE RVERIAAEAG AVLGLTLAEF
     GAALPDSVRW LPLDGLVRDE TLSMGRVEDT DGPLTPAELS GRTRVENPAY VVFTSGSTGV
     PKGVVVTHAG LAGLADAIVR AYRVEADARV LQCLNPSFDA AVLEWLMAFA AGATLVVAEQ
     DPVVGAELTG LIRYHGITQV CSTPAVLATL ESGALDGVRA VSSGGEPTPP DIVARFGIGR
     ELLNSYGPSE TTVAVTYTTG LVPGRDAGIG DPIPGAGMQV LDRLLRPVPI GMAGELYVTG
     PGVARGYAGR PGLTAERFVP VPSGPAGARM YRTGDLVRWN ESGVLDYVGR GDFQVKLRGM
     RIELGEIDAA LDTHPGVEIA VTVARPAPSG GTVLAAYVVP QPGHAVTERE LIDHVAHRLP
     PYMVPATVTV LGALPLTANG KVDRRALPEP VVAQSVSRAA GSEAERVLCA LFGEVLGTGE
     VGPDTSFFAL GGDSIMAITL VSRARATGLV FSAREVFEHR TPAALAAVVT RVEDRPRRLP
     ELPGGGVGRM PLTPVAAWLV RRPGWQHFAQ SMVVRVPVGA ESRALVRTLQ ALLDRHDMLR
     ARVVETEEGL QLEVPPVDST DVAELISRID CTTTPSGADI SESAIDDALP AAVDRLDPLS
     GVMFSATWLD GGTERSGRLA IVIHHLACDA VSWRILLPDL MSAWSAISAG AQPSLDDTGT
     SVRTWAYTLA ELATAVHEFE YWREVLAADT LLGRRRLDEQ VDTHRTAGRI EVEVPQAVSA
     TLLSRLATTY RCGVEDALLA ALTVALARGE STATGGETVV MVERHGRDEV AVPGADLSRT
     VGWFTAQVPV RLRPVGLAEA ALKVVKERLR SVPRGGFGYG LLRYSNAVTE RELAALPTPQ
     VGFNYLGQVP DAAVTGDWLP VSMASRLGGH ADPDMPLAAV VSIDAVTLES ERGPRIRAMW
     QFASEAIAAE AVESLTREWL SAIEEIAELI ARPDAGGLTP GDLPLLTVSQ AEIDGWERRF
     GRLTDVWPMT PLQRGLLFQS QLAEGGSDGY SVQAVIDIEA DLDPDRLTAA AQALVCRHDV
     LRAGFVASDS SAVQVIPADV AVPCAYREAF DATPEQLDAI AAEEFAVPFA VDAPPLIRFL
     CVAAGKRRYR LIITNHHLIL DGWSMPLLFA ELLGLYETAG DDAGFAVPVP FRTHLEWLAA
     RDARRAHTAW SEALAGLDGP TLIAPTAPRA GAPTTPVAHE VPLPAELPDA LRRTAAAHQV
     TVNTLVQVAW ALLLCEQTGG TDIVFGATVS GRPPELTGSD RMVGMLVNTV PVRISLDPGE
     TVGDLLSRVQ REQAALAEHQ HVGLDEIQSI TGLGPLFDTA TVFESYPVDA AALTAATRQA
     ALTVTGMRAQ DGTHYPLSLA AYANNGLRLE LTRSPRYFDA PAADALVAAL SRLLIALTGD
     SSRRAAQLTG TPADAGTAVR AGAPSGGVRL LPDLLSANGS PSAVAVLGWL EPSAVGDIET
     SQTIQLTYGE LDAASSRLAR RLIDAGAKPE TAVLVALPRS IDAMIAVWAI AKTGAAFVPV
     DVTQPAARTA AIAAESGAVL GITDAAFHSE SNPLPAGVQW LRMGDPGLAA ACAGLSDAPV
     TDAERLAPLR AEQAAYVVFT SGSTGTPKGV VVSHTGLADM VAAMGTRGGV AQGSRVMHCL
     NPAFDAAMLV WMSAFAAGAT VVVAPPEANA GADLAAAIRA GAATHLTCTP SVLATLDVDD
     LRRVRTVVLG GEPCPPGLVS RLGPGRALVN SYGPAETTIA ASFGDPMTGA TAALLGTPVP
     GTTFLVLDGW LRPVPPGAVG GLYVRGPGLA RGYAGRAALS ASRFVADPFS EGRRLYRTGD
     LMRCTAAGFE YVGRGDFQVK IRGIRVEPGE VDAVLTTHPR VDGAVTVARR NQAGAMTLCS
     YAAGETTAAE LLAWASDRLP RYLVPASLQM LPELPLTSSG KVDLRALPEP VLAQAEYVAP
     AGDEAAIAAA YAKVLGLDRV GARDDFFALG GDSLIAARVA ARLSADLGRT VPVRLLFEAP
     VVAELAGRLS GADTPRSGPA LVRRDHTGLV PLSPAQQRMW FVNRYDPTSP AYNVPVALRL
     SGHPDTTALR RALRDVIDRH ETLRTVYPDV DGVGMQQVLP AEDVPLDLDP RPVTGDRLAS
     AVAEVIGTGF DVTAAVPVRL RLFRVESTTV DTDPEHVIVL VVHHIATDGF SMAPLTRDVA
     AAYATRAAGV SPAWEPLPVQ YADYALWQRD RLGADDDPTS LGAQQTDYWK QVLAGIPDHL
     ELPTDRPRPA QATHHAAEHV ARVDTRLAAA IERRAREHRA TPFMVVHAAL AVLLSRLAGT
     GDVVIGTPVA GRGERELDDL VGMFVNTLVL RTGIRPEEDF GALLDRVRDT DLAAFERADV
     PFERLVEVLA PARSPARHPL VQVMLVFQNL ALPELRLPDL TVSPLELPQT SSRFDLSVTV
     VGDTDGMELR CCYATDLFDA STAAAFTDRL LRVLDDGTAE TSTPIGDLDL LTHGERQRMH
     RTEPPVAAPR TLADLMADAV ATNPEGVAVV CGDRALTYRE LDDRAERLAR RLAAAGAGPE
     TLVAVGIPRS IESVLAVWAV ARTGAAFVPV DPAYPPDRIA RIIDVSGACL GLTVATHRDR
     LPTTVDWWCL DEHDEQTTPA FLHEIVRDTA HPAYVIFTSG STGAPKGVMV THAGLANLAI
     AQRDRDHITS QSRVLHVASP SFDASVVELL MAVGAAATLV IAPPTVFAGP ELRELLSRHR
     VSHIALTPSA LATVDPGGLD DLRLIVTGGE PCPPELVAAW AAQGRSHFND YGPTEATVWA
     AGAALHPGEP ITIGRPAPGA RALVLDDRLR PVPDGVVGEL YLSGIALARG YFGRFDLTAA
     RFVADPHGHG QRMYRTGDLV RRRHGDLEYL GRTDTQVKLR GLRIELGDVE AALTAEPAVA
     RAVATVRDDG HGGLLAAYVV AAPGSQLEPA ALKKAAAQRL PSYMVPSAIT VLPELPRTAN
     GKLDLDRLPA PQPMTGDRQP PDGPVETAVA AAFAEVLGLD TVWRGDDFFA LGGNSLIATQ
     VVARLGATLD TAVPVRALFD APTVSELAAL VAAGDASGRP RPGPRPRPDH IPLSAAQQRM
     WFLNRYDPGS PLYNIPGAFE IAGALDISVL RTAIDDVVAR HETLRTIYPL GADGRPEQRI
     LSPATDSTPI TELDVTADEL GSALIAELSV GFDITRETPL RVCVLHVEPE RTVLALAVHH
     IAADGWSMAP LARDVMYAFA ARTTGVAPEW SPLPLQYADY ALWQQELLGS DHDPDSLANR
     QLDFWRTTLA GLPDMHALPT DRPRPTVPSG TGDRIEFSVP AEVHDRVQLL AREHGASPFM
     VVHAALAVLL ARLSGQPDIA IGSVVAGRGD GEFDDLVGMF VNTVVLRSHI DPAAGFADTL
     DAVRHADLAV YGNMDLPFER LVEALAPARS TDHHPLFQVL LAFQNVRTEA TTLPGLTIRP
     LDAPAPGAKF DLEWMLAEQF GAMGEPAGMT ASLTFATDLF DRGSAAAMVD GFRTLLDAMT
     ADPLAGVGAI GGPHPPALTV NPHAAPSAPV RERVRRVYRA PRTDAERTLV TAFESVLDSP
     RVGVDDNFFD IGGNSMGAVR LVTEVRDTTG IPMPLQWMFL DPTPAALARR LVETAAQPDV
     DPAMRVLLPM RPQGEGPALF CVHPAIGLAW CYGGLVQYID GAHPIYGIQS PGVTDGGTAD
     RTVHDLAVRY VEEIRRVQPE GPYHLLGYSA GGPLAHAMAV ELRRRGAPVP SLIMIDSRAD
     VAVPDDSAIP PLSLLLAEFG GIDVPPELEH LTAAQAAELL EASGISFTAT ELEHFYGDLR
     HLLRQIAAHD HEVFDGDLLF FAAAYNPDPN PNVTTWRPYI SGAIHDRPLP YGHNEMITAE
     ALAIIGPLVD AYLKR
//