ID A0A386ZP82_9NOCA Unreviewed; 440 AA.
AC A0A386ZP82;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=Acetyl-CoA C-acetyltransferase {ECO:0000313|EMBL:AYF79256.1};
DE EC=2.3.1.9 {ECO:0000313|EMBL:AYF79256.1};
GN ORFNames=D7D52_21470 {ECO:0000313|EMBL:AYF79256.1};
OS Nocardia yunnanensis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=2382165 {ECO:0000313|EMBL:AYF79256.1, ECO:0000313|Proteomes:UP000267164};
RN [1] {ECO:0000313|EMBL:AYF79256.1, ECO:0000313|Proteomes:UP000267164}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFHS0054 {ECO:0000313|EMBL:AYF79256.1,
RC ECO:0000313|Proteomes:UP000267164};
RA Zhang J.;
RT "Nocardia yunnanensis sp. nov., an actinomycete isolated from a soil
RT sample.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|RuleBase:RU003557}.
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DR EMBL; CP032568; AYF79256.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A386ZP82; -.
DR OrthoDB; 1402717at2; -.
DR Proteomes; UP000267164; Chromosome.
DR GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR42689; ACETYL-COA ACYLTRANSFERASE FADA2 (3-KETOACYL-COA THIOLASE) (BETA-KETOTHIOLASE)-RELATED; 1.
DR PANTHER; PTHR42689:SF1; ACETYL-COA ACYLTRANSFERASE FADA2 (3-KETOACYL-COA THIOLASE) (BETA-KETOTHIOLASE)-RELATED; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:AYF79256.1};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:AYF79256.1}.
FT DOMAIN 21..290
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 298..440
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 105
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 397
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 427
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 440 AA; 46296 MW; 02F50093980A4F3F CRC64;
MTTKARSAKA AAKTTKQARP VAILGGNRIP FARSDGKYAH ASNQDMFTAA LNGLVSRFGL
QGERLGMVVG GAVLKRVGEH GMIRESVLGS TLSPYTPAHD LQLACGTGLQ SIVTVADGIA
LGRLENGIGG GTDTTSDAPI GVSEGMREWM LDANRAKKNS DYVKLVGRLR PSMVGIEIPR
NAEPRTGLSM GEHAAITAKE FGIAREAQDE LAYLSHKNMA AAYDRGFMDD LITPFLGLTR
DDNLRPGSTI EKLSTLKPVF GVKAGDATMT AGNSTPLTDG ASAVLLGSEE WAASRNLQPL
AYLVDSEVAA VDYIHGPDGL LMAPTYAVPR LLARNGLTLQ DFDYYEIHEA FASVVLATLQ
AWESDQYCKE RLGLDGALGK IDRSKLNVNG SSLAAGHPFA ATGGRIIAQT AKQLAETGGG
RALVSICAAG GQGVVAIVER
//
