ID A0A387BM99_9LACT Unreviewed; 320 AA.
AC A0A387BM99;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000256|HAMAP-Rule:MF_01811};
DE AltName: Full=Foldase YidC {ECO:0000256|HAMAP-Rule:MF_01811};
DE AltName: Full=Membrane integrase YidC {ECO:0000256|HAMAP-Rule:MF_01811};
DE AltName: Full=Membrane protein YidC {ECO:0000256|HAMAP-Rule:MF_01811};
GN Name=yidC {ECO:0000256|HAMAP-Rule:MF_01811,
GN ECO:0000313|EMBL:AYF99660.1};
GN ORFNames=D7I46_00270 {ECO:0000313|EMBL:AYF99660.1};
OS Lactococcus allomyrinae.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus.
OX NCBI_TaxID=2419773 {ECO:0000313|EMBL:AYF99660.1, ECO:0000313|Proteomes:UP000269374};
RN [1] {ECO:0000313|EMBL:AYF99660.1, ECO:0000313|Proteomes:UP000269374}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1JSPR-7 {ECO:0000313|EMBL:AYF99660.1,
RC ECO:0000313|Proteomes:UP000269374};
RA Heo J., Kim S.-J., Kwon S.-W.;
RT "Genome sequencing of strain 1JSPR-7.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. {ECO:0000256|HAMAP-Rule:MF_01811}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01811};
CC Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01811}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01811}.
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DR EMBL; CP032627; AYF99660.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A387BM99; -.
DR KEGG; lact:D7I46_00270; -.
DR OrthoDB; 9780552at2; -.
DR Proteomes; UP000269374; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0051205; P:protein insertion into membrane; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd20070; 5TM_YidC_Alb3; 1.
DR HAMAP; MF_01811; YidC_type2; 1.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR028055; YidC/Oxa/ALB_C.
DR InterPro; IPR023060; YidC/YidC1/YidC2_Firmicutes.
DR InterPro; IPR047196; YidC_ALB_C.
DR NCBIfam; TIGR03592; yidC_oxa1_cterm; 1.
DR PANTHER; PTHR12428:SF65; INNER MEMBRANE PROTEIN ALBINO3, CHLOROPLASTIC; 1.
DR PANTHER; PTHR12428; OXA1; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR PRINTS; PR00701; 60KDINNERMP.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_01811};
KW Chaperone {ECO:0000256|HAMAP-Rule:MF_01811};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288, ECO:0000256|HAMAP-
KW Rule:MF_01811};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01811};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927, ECO:0000256|HAMAP-
KW Rule:MF_01811}; Reference proteome {ECO:0000313|Proteomes:UP000269374};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|HAMAP-Rule:MF_01811};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_01811};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_01811};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_01811}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..320
FT /note="Membrane protein insertase YidC"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5039397897"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01811"
FT TRANSMEM 142..165
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01811"
FT TRANSMEM 185..202
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01811"
FT TRANSMEM 214..232
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01811"
FT TRANSMEM 238..259
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01811"
FT DOMAIN 68..256
FT /note="Membrane insertase YidC/Oxa/ALB C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02096"
FT REGION 293..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..312
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 320 AA; 35331 MW; B6FDA859364C12BD CRC64;
MKNSKKKLTL AGISVAALLL LSGCVQTHIV NGVRVPTEAA THGLTYNLLV RPMSAFVDLF
AHNLGMGYGW GIILVTLIIR FLILPLGLNQ AYKSTYMQEK TAYLAPVFAP LNERLKAATT
SEEKMAAQQA LMKAQKDNGI NMLASIGCLP MLIQWPFFIA LYNAAAYTQG ISNATFFGIP
LGHPSIVLTI ISGALYFIQT WISTFSMTPE QKKTGMTMLI MSPAMIVIFS FMSPAGVALY
WAVGGFVIVI QQVIITFIMK PRMRRKIDEE FTKNPPKIND EGVKDVTPTS VQENFKAITS
ERNDEERKKG GRNAGKQNRK
//
