ID A0A388K4C4_CHABU Unreviewed; 550 AA.
AC A0A388K4C4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Pseudouridine synthase RsuA/RluA-like domain-containing protein {ECO:0000259|Pfam:PF00849};
GN ORFNames=CBR_g48327 {ECO:0000313|EMBL:GBG64859.1};
OS Chara braunii (Braun's stonewort).
OC Eukaryota; Viridiplantae; Streptophyta; Charophyceae; Charales; Characeae;
OC Chara.
OX NCBI_TaxID=69332 {ECO:0000313|EMBL:GBG64859.1, ECO:0000313|Proteomes:UP000265515};
RN [1] {ECO:0000313|EMBL:GBG64859.1, ECO:0000313|Proteomes:UP000265515}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S276 {ECO:0000313|EMBL:GBG64859.1,
RC ECO:0000313|Proteomes:UP000265515};
RX PubMed=30007417; DOI=10.1016/j.cell.2018.06.033;
RA Nishiyama T., Sakayama H., Vries J.D., Buschmann H., Saint-Marcoux D.,
RA Ullrich K.K., Haas F.B., Vanderstraeten L., Becker D., Lang D.,
RA Vosolsobe S., Rombauts S., Wilhelmsson P.K.I., Janitza P., Kern R.,
RA Heyl A., Rumpler F., Villalobos L.I.A.C., Clay J.M., Skokan R., Toyoda A.,
RA Suzuki Y., Kagoshima H., Schijlen E., Tajeshwar N., Catarino B.,
RA Hetherington A.J., Saltykova A., Bonnot C., Breuninger H., Symeonidi A.,
RA Radhakrishnan G.V., Van Nieuwerburgh F., Deforce D., Chang C., Karol K.G.,
RA Hedrich R., Ulvskov P., Glockner G., Delwiche C.F., Petrasek J.,
RA Van de Peer Y., Friml J., Beilby M., Dolan L., Kohara Y., Sugano S.,
RA Fujiyama A., Delaux P.-M., Quint M., TheiBen G., Hagemann M., Harholt J.,
RA Dunand C., Zachgo S., Langdale J., Maumus F., Straeten D.V.D., Gould S.B.,
RA Rensing S.A.;
RT "The Chara Genome: Secondary Complexity and Implications for Plant
RT Terrestrialization.";
RL Cell 174:448-464(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a uridine in RNA = a pseudouridine in RNA;
CC Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-COMP:12069,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC Evidence={ECO:0000256|ARBA:ARBA00000073};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GBG64859.1}.
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DR EMBL; BFEA01000055; GBG64859.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A388K4C4; -.
DR STRING; 69332.A0A388K4C4; -.
DR EnsemblPlants; GBG64859; GBG64859; CBR_g48327.
DR Gramene; GBG64859; GBG64859; CBR_g48327.
DR Proteomes; UP000265515; Unassembled WGS sequence.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006224; PsdUridine_synth_RluA-like_CS.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR PANTHER; PTHR21600:SF40; PSEUDOURIDYLATE SYNTHASE RPUSD2; 1.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR PROSITE; PS01129; PSI_RLU; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265515}.
FT DOMAIN 10..164
FT /note="Pseudouridine synthase RsuA/RluA-like"
FT /evidence="ECO:0000259|Pfam:PF00849"
FT REGION 418..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 550 AA; 59990 MW; 9961793DEBC6C7BD CRC64;
MSFVHVVHSC GQYRKNTVMG ILQAEENLGP LFPIHRLDRL VSGLLIFARN SSAAERFRKD
VQGGKVEKEY FARVIGVFPE EEVEVSAPVL YDPKEGHSIV ETEIPEDDPR HRQRQARKDQ
ILSNGAKCKD ARTRFKRRST DGETSIVSCM PLTGRTHQIR VHLQYLGHPI ANDALYLRSD
IDNPLRKRSH ARTNADMAAK KAFAGGESAV VSRTEMPARH APYEGVSGSP KPIIETSESQ
TYMAPAALST NKDDGVMEGS RSVPGICVDV PSKSQGVGEK DDVPRVQAEK LEETERQKSA
NLHEVRGMSA GADLRSMERQ GGAEVESYDG NVIAEESSAN ARQGNTCTSS ISLDMKATEE
SGVRVEVKLE ETSNASLPLS GSAVVLEDKS QKQNSGSSSA CTSFDRLQQS ALPVLSSHMS
GQELQADDRT QAVASRAVES SETSVAVHQT TDSSGESRSR NNCSGSAHTQ NVGITQEEQG
EPGHEHNAET RKLRNGTIDA FAFQLDPLCT HCPSLAPSGY EEELEGLWLH CTRYAGPSWS
YQCPLPSWAL
//
