ID A0A395GPD9_9EURO Unreviewed; 4907 AA.
AC A0A395GPD9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN ORFNames=BO80DRAFT_390095 {ECO:0000313|EMBL:RAK97206.1};
OS Aspergillus ibericus CBS 121593.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1448316 {ECO:0000313|EMBL:RAK97206.1, ECO:0000313|Proteomes:UP000249402};
RN [1] {ECO:0000313|EMBL:RAK97206.1, ECO:0000313|Proteomes:UP000249402}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 121593 {ECO:0000313|EMBL:RAK97206.1,
RC ECO:0000313|Proteomes:UP000249402};
RG DOE Joint Genome Institute;
RA Vesth T.C., Nybo J., Theobald S., Brandl J., Frisvad J.C., Nielsen K.F.,
RA Lyhne E.K., Kogle M.E., Kuo A., Riley R., Clum A., Nolan M., Lipzen A.,
RA Salamov A., Henrissat B., Wiebenga A., De vries R.P., Grigoriev I.V.,
RA Mortensen U.H., Andersen M.R., Baker S.E.;
RT "The genomes of Aspergillus section Nigri reveals drivers in fungal
RT speciation.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
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DR EMBL; KZ824465; RAK97206.1; -; Genomic_DNA.
DR STRING; 1448316.A0A395GPD9; -.
DR VEuPathDB; FungiDB:BO80DRAFT_390095; -.
DR OrthoDB; 1221059at2759; -.
DR Proteomes; UP000249402; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0000027; P:ribosomal large subunit assembly; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 7.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR048617; MDN1_AAA_lid_4.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 9.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 3.
DR Pfam; PF21108; MDN1_4th; 1.
DR PIRSF; PIRSF010340; Midasin; 1.
DR SMART; SM00382; AAA; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRNR:PIRNR010340};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR010340};
KW Nucleus {ECO:0000256|PIRNR:PIRNR010340};
KW Reference proteome {ECO:0000313|Proteomes:UP000249402}.
FT DOMAIN 4691..4895
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 4061..4544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4556..4579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4093..4111
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4112..4160
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4161..4189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4196..4214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4215..4233
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4234..4258
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4259..4357
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4380..4410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4411..4432
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4449..4473
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4513..4544
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4907 AA; 546754 MW; C9AD0D1188F3BAF2 CRC64;
MNARPSYEGT LNESQLFEQL PNEIAELIRT ASGTQYLNAL AVGALRPRCT EGFFCLYEPI
FVDLAARWLL SESQVDQTDI LSAFSRILPL APYLRSFASQ YAMSRAGPLS ALAASDELTL
SQMNDATIRA LLLAIFRLLS YDTETFSKAV SPSQLQFLFR HRDPSVSYLA IRCFGMYMSA
ADAATEDIIR AKFADNIIEG DWEGITIDYR CLGLWEERRW NTLEKQVQLA RSTRPASESL
SQIETLREYF TARTAEVCGV LIPRQQGTSP PPSSIVRTPT AVGNLRKIAT ALTAPEPILL
IGLPNSGKTT LINDVAATMG QSESMVTLHL NEQTDAKSLL GMYSTSPATG SFSWQPGVLT
KAAREGRWIL IEDLDRAPSE VIGLILPIIE RGELTIASRR ERIKCAEGFK IIATMKSSYN
ISGEEIAPST SILGSRLWQR VQIDSLTIDE VREVITQKFP LLESRVRTIM DVYQRLCSSF
HGSLAIKSSQ GRTPGLRDLV KLCSRMHRRL QRLGAKTGYE ATPEGAEDEN FLDFVDVFLK
YIPEKNMTDT LASVVAEALQ ISPQRARFCL HERTPSYSDQ GNSITLGREV CRKIKVPGGS
ASKTAAASSR FASTRAALGL MEQVAAAIQM AEPVLLVGET GIGKTTVIQQ LATLMRQKLT
VVNLSQQSES TDLLGGFKPV NIRTMAVPMH DEFVSLFELT FSAKKNQKFL QSVGKSVAAG
NWVRLVNLWH EAVRLADGVF KPGHGSSQGA EEQPTKKRKL DSPKYQFLRQ RWERFAAQLN
DFESQVSQGD AKFAFAFVQG KIVRALRNGE WVLLDEVNLA SPDTLENIAS LLHHGSEGSP
SVLLSEAGDV ERVFGHPEFR IFGAMNPATD AGKKDLPPGL RSRFTEFYVQ SPDSDLDDLL
SLIHKYLGDL ALTDSRAVPD LAQLYMETKK LSTENKLTDG AGQRPHFSIR TLVRALVYVA
DHAHIYGLRR AIYEGFSMSF LTVLSQASER LLAPLLERHI FSNVKNARGL LNQTPRPPTD
GNDYVQFKHY WMRRGHLTPE EQPHYIITPF IEKNLKNLVR ASSTRRFPVL LQGPTSAGKT
SMIEYLAKVS GNKFVRINNH EHTDLQEYLG TYVSGDDGAL RYQEGVLVEA LRNGYWIVLD
ELNLAPSDVL EAMNRLLDDN RELFIPETQE VVRPHPNFML FATQNPAGLY GGRKVLSRAF
RNRFLELHFD DIPESELEYI LKERSQIAPS FCTRIVSVYR KLSLLRQANR LFEQKNSFAT
LRDLFRWALR RADDREQLAI NGFMLLAERV RNPQERAAVK GVIEEVMRVR IDEDVIYSSS
EMEKRAPLLA QLAPGIVWTK AMRRLFVLVS TALENNEPVL LVGETGCGKT QLCQAVAEIY
KKQLLIVNAH VNLETGDLIG AQRPVRNRAA IESQLLSDLQ VLFSEELAQS RSLEELKQAF
SAISADQLQL LDAELISRIE KNVARSNALF EWSDGSLITA MKTGQFFLLD EISLADDSVL
ERLNSVLEPH RSILLAEKGP INSMVVADDG FQFLSTMNPG GDYGKRELSA ALRNRMTEIW
APQLSEDEDI LPILQRKLTL GTEHVPKGML QFAKWFKEVF QNSSTSSLSL RDLLAWVEFV
NKCQSSDPLF AIVQGAAMVF IDTLGANPAA MLATALHNLE GNRQLCLDKM HELFDVDASA
IYLQKSSVGI EGSSLRVGPF CLPMNSNSMP DPDFIMDAPT TIANSVRIAR GLQLPKPILL
EGSPGVGKTT LVTALARALG KPLTRINLSE QTDLTDLFGS DVPVEGGDVG QFAWRDAPFL
QAMQRGDWVL LDEMNLASQS VLEGLNACLD HRQMVYVAEL DQTFRRHPDF VLFAAQNPHH
QGGGRKGLPA SFVNRFTVVY ADSFTNTDLK RICAKLFPGS PAEQTDGLVE FVSLLNKAIQ
ERRLGAVGGP WEVNLRDIQR WLQLADRGSL QISTQSFLEV IICQRFRSEE DRQLVSTLYK
QVFSDASTHA KSYYHNLTPD YMQVGLGIMQ RDLVLQETAS PQMRILPGDL PILESLMLCI
EQSWPSILVG PSGCGKTTLI RKLAALNGAS LVELALSADT DTMDLIGGFE QIDYRREISS
LVHQVSLFLR RNVISAYAGD DTSVAPAFLE LYEQLQGPDV QLDALCSSLQ KLYHSYSQPA
LEKLFSHAQR LLKVTKQTDS MKVGFEWTEG VLTQAVQHGQ WVVLDNANLC NPSVLDRLNS
LTEPNGALIL NEQRTEDGNA RVVRPHPNFR LFLTMDSRHG ELSRAMRNRC VEICFLSDSS
NTVATSMPAY TYESSLYRLR SVWDLDLAVA SEGTTDILPE VCLDHLSIAD LSYLQRALKL
TPQYASDVAR EPFSSAVDRY VSAIHANASC KPFESTKKEV MLGRTSFAIQ GRLQPLHPLV
NEPLASIMHQ EVPFVWLVVL AYLQEYKLDL HRLRQGLLRA DESGKQLKPS QMSRLERSLA
SGRIPSLMKD ATQPVGPFLS DCGQAMYDFI QALDYDALHA PDMVRALRAI VDFTSDMFTL
TAANEVDQGE FQIYLQIGKE LCASLLDSWA PLKQLAVAFS QALDRFKENW SLTTGLSMQR
LWESWRPSTP STQDQLQLLL ELESVASEFT QVATKTHLDL SQLSQVRDSL IGGQEAILNG
ADEGFPIQGL RQTVAELAAC VQDTDSSQRP YFSNNFEALC QYHDIASLGQ SQLDDGQVVR
AILPLLAGRA ARPLDGSSLQ SQIPNILHKL SLFSGSEHSV FGSAISGNIS LSLLERLAFI
GSTSLGQMDA LEVEKKTLSK ALTLTSREIG LDQFKRLRQV MARLTIELAF LHRDFFEPQS
LEHLIIILRA IEEKGSYDGP ALPAIHVATN LAQDHYFKRF AKEDIPRLVA SLAVGESPVE
STGVAIVQLA VIFLRLFVPD KPFDPSLGLV VQRKRHSQRS LELTTKAEAI SSFEVGFSGQ
ASNIRLEFLQ KELHDLGSAP PPSSVSRPPI SEINLLHGEF SSLVNSVLDR RPEEIVSAVS
GNGDEDSERQ RMIGLLRDNV RQLSHRLSAN YRSYDDITTP VVRFLQILDL GLYLSSSPSQ
SNDSQILKAV RETTPFLGGL IYPVSDLSLQ RSEANSTLDT DLWFHELSSL RIAENADPGV
IGTRAGRDTL RRLFEQFHAL WKTRLREDQE EEARKSEFYH FKGSWEDSEE VDENELRQLF
PTYEDADEEA QAPGRFDPKS ISIRLASLHA KLFQSENREE ALSAYVKQAS TLLGSTWSDN
HSMSDVDPKD QISGVLLLLE DSINTGQGQP ADKYNFYLDA NLAEAKRLVT LTLATKARFT
QIQKSWPDHA VLEDVIVCCR EILQFKHTEP VAKFITKVEK LHALVHEWQL VASREYSAAT
VYDDITAMII SWRRLELSTW AKLLDIENDK CTQDVSSWWF IAYEAIIRAP IQIAESGQME
MSEHVQEITA TLEQFFNTTT LGQYSERLLL VKNFQSLLRL YAQDLPSLGH LISALDNFLV
RYKQFEPSVH KLLAEKRSAL EKDIKEQILL ASWKDTNIVA LKESSRRSHN KLFKLVRKYR
AVLAQPAQPI VEQDMPDHED SSIPQHEITM PSTVFPEALA MCQKEERIWA DRPPRFKNPD
ATAGSMMQLY SSIPSEFDIA DDLDGFVKYV IESIQEFKSQ TPKTLTEENK DDVQHLKVQK
RRFYADTLRR LMDMGVKRSA STSLIETQAS IAQVLASVPA LEADTALSHL TTSSDLYFHK
FLDLLPRVRL AAHNYSEDLS NVEISRSSGS MEHLLSLARK QRTSISPALS ALTALQSTLL
KVSNLWHSSS IFKAPSEFLV EKSEVSRAVA WLTPILGLAA TVVSLHAKFS GISSTSILQS
LQAWRDTFDR LRTSLGSLPE LPLGVASQLH SDTVEEASAS FEKLNVDLTR WAEERPDLSF
VLGQIVPWLR AKTMSSDSEF DETVSIEQFD TGLVAAVDKI LVSLQKLKEL PSLLASPGAL
SRSDEFFVRA LKVLHISGIT TSIESVLEQL QCLQSRSAPG IPFAIALVAS LLPIMHKYFH
ICKDVVDRYL TVHRQTCKMS YILTKSFAQI ASEGFCSPAE ASTEESKSGK LESGTGLGEG
EGAEDISKDV GDDEDLSELA QEQKGESTED IENSEDAVNM DQEEMQGEEG ERKEGDEEDD
ESGSEEEGDI DEEVGSVDDL DASAVDEKMW DGEHDEQQKE TETDQGKGVS ESDEQTAAGE
QEKEKEKAQE GEQGEKDEDA EEEEDEEGEE KPDEEGEAVG REDMDVTDPH AKEEEALDLP
DEMQLDGEEK GDEGESDDGL DDGMDDDLPP VEDNDESMDG KDTAEDEAME GVEEQEPEQT
EEGMPDEEAM ETNEGEGNEE TNEAGEEAEE EEKEDFLAQR DENEMAGEEV APSEAVNGGL
GADQDQNQDK GESGNAQQES GSTDPSTEKE QKTGAAQEGD ENQRHNDEGG ANDANPDDPQ
LQAFKKLGDV LEQWHRRQKE IMDASKQEEG ESEEPMPQDT DMADADFEHL ADQDDVADTQ
ALGQASEDQA KALDQNKGVE SDVKPEGNDV LPDVTDDDHQ DLPDNKLEDE MQLDQGLPTE
SQTAGAIIPG NTHTQERTTD AAGQQEAIDE LDEVDAHLAA IHLSSNLPPL TPRDEAQRLW
SYYESATTDL SLSLTEQLRL ILAPTLATKL RGDFRTGKRL NIKRIIPYIA SQYKRDKIWM
RRSIPSKRNY QIMLAVDDSK SMLESGSGQL AFETLALVAK SLSMLEAGDL CVLGFGNEDH
VRVAHEFGKP FSSEAGTQVF QHFSYQQTGT NVRKLIADSI ALFREARWKQ SPGSGNADLW
QLELIISDGI CEDHETIQRL VRQAQEERIM IVFIIVDAVK GSSILDLSQA SFEADESGSG
EMKLKMKKYL EGFPFPYYLV VRDVRELPAV LATALKQWFA EVVDVSS
//