ID A0A395GYJ8_9EURO Unreviewed; 2119 AA.
AC A0A395GYJ8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=SH3 and Ded_cyto domain protein {ECO:0000313|EMBL:RAL00403.1};
GN ORFNames=BO80DRAFT_96988 {ECO:0000313|EMBL:RAL00403.1};
OS Aspergillus ibericus CBS 121593.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1448316 {ECO:0000313|EMBL:RAL00403.1, ECO:0000313|Proteomes:UP000249402};
RN [1] {ECO:0000313|EMBL:RAL00403.1, ECO:0000313|Proteomes:UP000249402}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 121593 {ECO:0000313|EMBL:RAL00403.1,
RC ECO:0000313|Proteomes:UP000249402};
RG DOE Joint Genome Institute;
RA Vesth T.C., Nybo J., Theobald S., Brandl J., Frisvad J.C., Nielsen K.F.,
RA Lyhne E.K., Kogle M.E., Kuo A., Riley R., Clum A., Nolan M., Lipzen A.,
RA Salamov A., Henrissat B., Wiebenga A., De vries R.P., Grigoriev I.V.,
RA Mortensen U.H., Andersen M.R., Baker S.E.;
RT "The genomes of Aspergillus section Nigri reveals drivers in fungal
RT speciation.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR EMBL; KZ824440; RAL00403.1; -; Genomic_DNA.
DR STRING; 1448316.A0A395GYJ8; -.
DR VEuPathDB; FungiDB:BO80DRAFT_96988; -.
DR OrthoDB; 8258at2759; -.
DR Proteomes; UP000249402; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08679; C2_DOCK180_related; 1.
DR CDD; cd11684; DHR2_DOCK; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF10; MYOBLAST CITY, ISOFORM B; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000249402};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 7..88
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 625..806
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1449..1859
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 426..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1847..2088
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..514
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1905..1950
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1951..1969
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1970..1984
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2005..2023
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2024..2085
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2119 AA; 236539 MW; AF7F8342CDF7927A CRC64;
MPWRPLPRIA FAVAIYPFQP TTPADLPLEL GDELYIIEQG GANGEWYRGY LVAPPSLLAG
LTSTKGQTLE ARVFSGIFPR NCVEIREVLG DGEKTITNGD RSSMALLAGA EGEMRNSVAS
FQDDENAFGE VSNVVIAKKG KPSQIFIQKL DEDGRGSPAS PRTPRRDLLR TNSMVLAPMN
VAPRDPDAPK PAAPVPMLKI GDETPTSLSE PLVDEIASCL REWHSTNLHQ LLLSRQYVTV
EEMSKIVQEL DFARRQLLYN VLTAQEKESL RQEVVWKLVR GNKALGGEII VRDPQQRGRL
LTGDDSAVEL TRLQSEMGML DSSPTQQSDV AALHHLLLEV NAVSGHAPGP VTLAAYLCSQ
SETGALVPLS ETYVLDIPSP EKFASMGQSA RLKTLFTDLS STDIGDSSTN GPKLYLIVAV
RAPETASVTN AAAQPRSSIS RDSSSGSKQA TGVNQSVKGS LRTRRSMMWT SKPRGIQSPE
QAKETSKNPP QSSGSSTSTI TKERSGSQST KDTTQIRTVG VGFLEVSQIL RQEKDAEQVI
NIWSPSEESE DKEGRDDGFD GVVRTLLPSP TGKYVRSQRA ARLHFHLYPH VDPDADSLVR
RNPTTLHNVI QTRRIGFSQA PTKPRSDIYV TISHATFPPE ALLSHPHSGQ VPVPAHTGLR
NLQLTLEVRT SSGTRVERCV IPSSNHAAQT AWRTTIADRG APWNQTIRLN IPTDQIPTSH
LIMSIADAPE FPFALAWMPL WDNQAFMRDG PHSLLLHAYD KCTSNIENGK GAYLSLPWSS
LGKNESAKDE AITGPLATLR LDTHLCSTEY SQDQVILSLL NWRDRPVNEV LDTLKRVLFV
PEIEIVKQLS SVLDSLFGIL VENAGNEEYE DLIFNNLVTV LGIVHDRRFN LGPLVDHYAD
NQFNFPFATP CLVRSYLRLL PSSSDAQQSR NLRATFKVGR HVLKFIINAR QQQKAKEEGI
GITRVQSTFN RDLHTIFKSL EALMKNPSPA MVGSKTLVVQ HFHTWLPELS KVLSRDEVIM
IALSFIDSCK DVTGMLILYK LVLIQHYTRL EIFSSGSERK SLISSCISWL APYWGATGAV
SDLYRDQVRL CCAIVAELLK QPDPYLYEFV PKIVSSYYSI IPDGVEETSY LSLLFSKSFP
FQVKTSKYSQ RFDEALVELS AILAGAATIP NPKRPRLKGL ELSSFLSQAF EVHTSILNCE
AYPESWLSVH VYNHRATVKS LEYLATILTN KFLPSPEEAE SFDTRLWETF FMTLLKVVSS
DALALETYPE QKRRAIWKIA GDVREQGADL LHSSWESIGW ETTDEEREHY GLSKLGGYQV
QYVPGLVAPI IELCLSVHEG LRHVAVDILR TMILSEWGLN QDLSIIETEV ISSLDNLFKR
KNMSESVVQK LFIGELSEHF EGYAEFDEDL SNAVKALIAT VDELLDLFVA SQGGSMAESL
HTLRLMKYMK DMGREDIFIR YVHELAQVQA AAGNFTEAGM ALQFHADLYD WDAQRTLPEL
LNPAFPEQTS FERKESLYFA VIQYFEDAKA WAHALLCYKE LAQQYEDTVV DFAKLSRAHG
SMAKIYDIIA KEDKQFPRYF RVLYKGLGFP TTLRDKEFII ECAATERMAT FIDRMQREHP
AAQVVSSGEI QDYEGQFLHI NPVSVHRDVD HPVYQRSKIP QSVRDHLLVS EPCHFSSTLR
RHVRDADVKA QWVEKTVYTT AEPFPNILRR SEVVEVKEVA LSPLQTALER TWRKTQELSM
LQRRAASGED MSLNNLTEAL EQLLELNAAT PNCVAAYRQF LSDVPEEDEG GLVTPKPADP
LKNALAVALI DHALAIKQAL AMYHRPAHQA TQAELMRRFE EAFGPEISSL RPAELETPQW
PRRTTPKSLE ERQKQPASRA LSPEQELIRS SRKNHSRKHS AKQSVSHRIS VMNPFKRTNH
VASNSVATVQ EAPKGSADSK VNGTTTEEHV NGEAADQDDA ATIHSRTTTR SRDTHHRRRS
RLGDVLHKHA SSLSISPSAT EESQSQKKQR TRSASRDTAA KSHESMSRTT SHTNGTSTDD
RPSVTSPKGG WSTIPSISDY PRPVTRSSMT SIRSPEITSP VSHTPGRRDS VLKRFSLLKG
VSRKGSRLDF RTGTPVHEE
//
