ID   A0A395HBL2_9EURO        Unreviewed;       379 AA.
AC   A0A395HBL2;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=Cyclin-like protein {ECO:0000313|EMBL:RAL04949.1};
GN   ORFNames=BO80DRAFT_441174 {ECO:0000313|EMBL:RAL04949.1};
OS   Aspergillus ibericus CBS 121593.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=1448316 {ECO:0000313|EMBL:RAL04949.1, ECO:0000313|Proteomes:UP000249402};
RN   [1] {ECO:0000313|EMBL:RAL04949.1, ECO:0000313|Proteomes:UP000249402}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 121593 {ECO:0000313|EMBL:RAL04949.1,
RC   ECO:0000313|Proteomes:UP000249402};
RG   DOE Joint Genome Institute;
RA   Vesth T.C., Nybo J., Theobald S., Brandl J., Frisvad J.C., Nielsen K.F.,
RA   Lyhne E.K., Kogle M.E., Kuo A., Riley R., Clum A., Nolan M., Lipzen A.,
RA   Salamov A., Henrissat B., Wiebenga A., De vries R.P., Grigoriev I.V.,
RA   Mortensen U.H., Andersen M.R., Baker S.E.;
RT   "The genomes of Aspergillus section Nigri reveals drivers in fungal
RT   speciation.";
RL   Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC       regulatory module of the Mediator complex which is itself involved in
CC       regulation of basal and activated RNA polymerase II-dependent
CC       transcription. The SRB8-11 complex may be involved in the
CC       transcriptional repression of a subset of genes regulated by Mediator.
CC       It may inhibit the association of the Mediator complex with RNA
CC       polymerase II to form the holoenzyme complex. The SRB8-11 complex
CC       phosphorylates the C-terminal domain (CTD) of the largest subunit of
CC       RNA polymerase II. {ECO:0000256|ARBA:ARBA00025278}.
CC   -!- SUBUNIT: Component of the SRB8-11 complex, a regulatory module of the
CC       Mediator complex. {ECO:0000256|ARBA:ARBA00011612}.
CC   -!- SIMILARITY: Belongs to the cyclin family.
CC       {ECO:0000256|RuleBase:RU000383}.
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DR   EMBL; KZ824422; RAL04949.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A395HBL2; -.
DR   STRING; 1448316.A0A395HBL2; -.
DR   VEuPathDB; FungiDB:BO80DRAFT_441174; -.
DR   OrthoDB; 1332948at2759; -.
DR   Proteomes; UP000249402; Unassembled WGS sequence.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd20546; CYCLIN_SpCG1C_ScCTK2-like_rpt2; 1.
DR   Gene3D; 1.10.472.10; Cyclin-like; 2.
DR   InterPro; IPR013763; Cyclin-like_dom.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR043198; Cyclin/Ssn8.
DR   InterPro; IPR006671; Cyclin_N.
DR   PANTHER; PTHR10026:SF112; CTD KINASE SUBUNIT BETA; 1.
DR   PANTHER; PTHR10026; CYCLIN; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   SMART; SM00385; CYCLIN; 2.
DR   SUPFAM; SSF47954; Cyclin-like; 2.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   Cyclin {ECO:0000256|RuleBase:RU000383};
KW   Reference proteome {ECO:0000313|Proteomes:UP000249402};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT   DOMAIN          62..161
FT                   /note="Cyclin-like"
FT                   /evidence="ECO:0000259|SMART:SM00385"
FT   DOMAIN          174..260
FT                   /note="Cyclin-like"
FT                   /evidence="ECO:0000259|SMART:SM00385"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          301..345
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   379 AA;  43079 MW;  25CD420C83A9A9E6 CRC64;
     MAPDKKDEAP SPDSVVPDPP PIHPSFIQVA KPYIFEQTIQ KCIAAMGVNP LREESLRLQG
     VTWIDNIRRV LYLPIRTFNT AVVYYHKFRL VHPDNEYNYM DAAAAALFTA CKIEDTLKRS
     REIVCAAYNL KLPAQEHMAP DNPVFEVHAR GIIGLERLML EASGFDFRTR HPQKTLVKLA
     RQYGLTSQSE VSSLAYRIAQ DLYRTYAPIK QTTSTMAFSC LELAGRLLDR RIEAVEKGVD
     YAKWKTSREE VMETLLDLLE LYTHNRAQTS VGPHFPADRF LTVRIPLNTE VESQKLPRYT
     NWVPEPRDSK PANGDKAAKD TAKLHPLTPI AANGDRPKAT EKGRDGAVRF MLDPECADAE
     KSHVAEYFKV EMEEYEVEE
//