ID A0A395HK96_ASPHC Unreviewed; 7054 AA.
AC A0A395HK96;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Acetyl-CoA synthetase-like protein {ECO:0000313|EMBL:RAL06684.1};
GN ORFNames=BO97DRAFT_466320 {ECO:0000313|EMBL:RAL06684.1};
OS Aspergillus homomorphus (strain CBS 101889).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1450537 {ECO:0000313|EMBL:RAL06684.1, ECO:0000313|Proteomes:UP000248961};
RN [1] {ECO:0000313|EMBL:RAL06684.1, ECO:0000313|Proteomes:UP000248961}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 101889 {ECO:0000313|EMBL:RAL06684.1,
RC ECO:0000313|Proteomes:UP000248961};
RG DOE Joint Genome Institute;
RA Vesth T.C., Nybo J., Theobald S., Brandl J., Frisvad J.C., Nielsen K.F.,
RA Lyhne E.K., Kogle M.E., Kuo A., Riley R., Clum A., Nolan M., Lipzen A.,
RA Salamov A., Henrissat B., Wiebenga A., De vries R.P., Grigoriev I.V.,
RA Mortensen U.H., Andersen M.R., Baker S.E.;
RT "The genomes of Aspergillus section Nigri reveals drivers in fungal
RT speciation.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the NRP synthetase family.
CC {ECO:0000256|ARBA:ARBA00029454}.
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DR EMBL; KZ824361; RAL06684.1; -; Genomic_DNA.
DR STRING; 1450537.A0A395HK96; -.
DR VEuPathDB; FungiDB:BO97DRAFT_466320; -.
DR OrthoDB; 2787863at2759; -.
DR Proteomes; UP000248961; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR CDD; cd05918; A_NRPS_SidN3_like; 5.
DR CDD; cd19542; CT_NRPS-like; 2.
DR CDD; cd19534; E_NRPS; 2.
DR CDD; cd19545; FUM14_C_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 5.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 6.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 7.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 4.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 7.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 4.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR PANTHER; PTHR45527:SF3; SIDEROPHORE SYNTHETASE (EUROFUNG)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 5.
DR Pfam; PF00668; Condensation; 7.
DR Pfam; PF00550; PP-binding; 6.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 5.
DR SUPFAM; SSF47336; ACP-like; 6.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 14.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00455; AMP_BINDING; 5.
DR PROSITE; PS50075; CARRIER; 6.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248961}.
FT DOMAIN 578..654
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1112..1188
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2230..2306
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3768..3844
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4862..4938
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 6399..6475
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 7054 AA; 779037 MW; 88CD89C2ADD59559 CRC64;
MRSPNDLTTS ATMEDIHQIW SWNANVPEAG ETCVHTLITD KALQQPDALA VDAWDGKWTY
GELEDTSTKL ALRLLDLGVG PATNVVICFE KSKYTPLAML AVMKAGGASI ALDTSQPQPR
LQSIINQVDP VVILCSASKS HLTKSIITES AVALTIDENS LSKMNFEPDS VARLPDVSLD
NNLYVVFTSG STGTPKGVVV THLNYSSVIL HQQEAHGFKS TSRVYDFASY AFDVSWSNLI
HTLTIGACLC IPSEQDRKDN LVESIRSLCA THVDVTPSVA RLIPDSLLCK IETLVLGGEK
LSAELARHLS SLVTLKNPYG PSECTPTSTI ATIRPDDDDS KISSIGRGLG VNSWVVDSEN
EGILVPIGQV GELLLEGPLL GNGYLNDQTK TTAAFVNNPL FLLNGGDGPG QPGRRGRLYK
TGDLVRYEKD GSLTFIGRKD TQVKINGQRV ELGDIEHHIY RHIPHGTVSV RQIAAEIISP
KTGSNAVLAV FLEVDLGVED TGTAEQLFSK TEKMMSNLRS NLARDVPSYM VPAVFIPLRN
FPLSPTGKTD RRQLRAIGES MDLTVLAGFG AAPNEAQIPL TLREKQLRRL WGSILRIDEN
LIALNDNFLQ RAGNPNAAMK LVTAARREGL SLSVANVLKY PRLQDMAQVV ETVEQEQAHE
IMPFELLSND INLDLALREA AASCNVQENQ IQDIYPCTPL QEGMISLSAK REGDYIMQYT
LELHHRCDIE RLGKAWATVV ATTPILRTRI VDITSQGLVQ AVLNEQWSSS SIQRRTLSQA
RDHKHQFGLG MPLGRFEIVT GDSSDFKHYF VWTLHHALYD GWSLQLLLEK LENEYAGKAD
AQSNSPDFKR FIRYISTRDG EKTHSFWTEQ FQDVEAQIFP SLPSVDYQPR SDKLYTHSVE
GIQWPKNGIT PSTTIRAAHS ILISSLTNSP DVVFGSITTG RQAAVDEVEE LIAPTIATVP
VRVSIDSKNE LGQFLQRIQS QAADMIEFEQ TGLHQIRHIN ADAERACQFQ TLLVVQPAEG
SATAPSDIFT NIADDIRKGD GNSAAELGTY ALTMECLLKK DGLDLHMNYC SAVISEHQVR
RLSQQFEHVL GQICHLMAII HRQRTTLESL RQPTSETERQ MQRIWAQVLN HNQASIGLDH
SFFQLGGDSI AAMEVVTEAR KLGLRLAVSD IFRRPKLQDV AKKACDSGQQ VYGEEQLMND
SEVQVNGGTE HTKLPDDAKA VAGHETQQVM VWEGMFDKEV YGTIDDVQLE KIGRDFIGWT
SMYNGNQMDN VELNEWLDDT IATIRSSGST ANILELGSGS GMILFNLVNG LHSYVGLDPS
EKAVDFVCST VKSIPQLADR VYNIKGTADN INSLGVPISA DMVIVNSVVQ YFPSQDYLLK
VIEDLVQLET VRTIFFGDIR SYALFREFQV TRALHIAGDT ATEDEIRQMM ANMEQVELEL
LVDPAFFTSL VDRFPGLVEH VEILPKRLKS TNELSAYRYA AVVHLKDSNP LAQPLQLHDI
QKESWIHYSG RQLNRQSLLQ LVQDSFLRDP SPSSVVAVCN IPYSMTVYER HVLEWLDSGL
TAGPDAEDWL SSIRQTSQEC SSLSALDLQQ IAHQTGWQVE ISWSRQFSQR GGLDAIFHRH
HSRGDRTSRT LFNFPTDHQE RPSQSLSNWP LQRKQQGEEK QITLGDVSTV CKEDLHDIWT
WNEIVPGALE ACVHDLISDT VRAQPQSPAI CAWDGEWTYI ELDDLSSRLA HALAPFGVAN
TVVPICFEKS KWTPVAMLAV MKAGAASVTL DASQPLERLR SIVSQTDPRV ILSSASKQDL
GVQLTRAPNL VVDQHSISTM HITAEPLPTV DPSSKLYIVF TSGTTGVPKG VIITHSNFSS
AIRHQQEAHG FKSTSRIYDF ASYAFDVSWS NFIHALTIGA CLCIPSDEDR RDDLAGSLER
LGATHVDMTP SAASLLPEKS FKRLETVVLG GEKLSVESAQ RWSSLVSLKN PYGPSECTPT
ATIATVTPTD EYKSSIGRGL GLNTWIVDTV TDSLVPVGGV GELLLEGPLV GAGYLGDDTK
TAASFVQDPQ FLLQICPQGQ ARHTRMYKTG DLVHYNPDGS LSFVGRKDAQ VKIHGQRVEL
TEIESHIRRT SKTIQVAVLF AKSGLCANRV VAFVCIQGTG QTQTAADQIR LIDPKYSTLA
TAYTESAKSS LSDTLPTYMI PSIWIPLQHV PLSTSGKLDY KALKSWLDSM DSKTFANILT
ASDGDVELRK AETELEQVIV GACATILNIT ASKVNLDRSF IANGGDSISA MRLVAHCRAN
NVVFSVAKLL KSKTLAALAS SSEIKSASNM LGFYEEKSDS FALSPIQQWF FEQGLYKRSN
DNFDNQGFYL KVKRPLLTKD IDSAISKVVQ HHSMLRARFH RNGDEWTQKT LKPDTNGLYH
FGVHHTCLPA DIERLALSRH QSLDIEKGPV FSADICHNAF GEQYLILIAH HLVVDLVSWR
VILEDIESLL GGSNLQPSLP FQVWNDMQIE RAKESSLLDP ENVLSTTGIN NNLDFWQATA
ETKNTVEDHL NFCTKIDSSI TELILKDANY PFNTEPMDLL LAAVWHAFFK TFPQRDGLTI
FIEGHGRESW SSDIDLSRTV GWFTTISPIH VSKSDVYQSV ASLVRVVKDA RRLLPANGWA
YFASRYLNES GKSAFKSHDS IMEITFNYHG QFQQLENEKG MFEKVTLSGV CEQGPALPAS
SLIAVEVSID RGQVTFDISA NRYINHQDGI SNWIKAISQS LETISNELVS TETSHRTLCD
YEFLSLGYTE LNRLQESVIP EIEKLNDSTV EYIYRCLPTV DGILISQFKD PESYKTVQHF
EITSHIDDQI DLERLSLAWQ KVVANQPALR TVFIPGTDKA AAFNQVVLSQ YHAELIILHT
ASDEYTEALE MFKNLTPINY QSFKPPHRVA LCRISPSRVL CQVEMSHAIT DGASTSILAN
DLLQAYNGNS MPINLMDTAC EFARAQLTSS FGEKLSYWKK KLSGMDPCHF PKISGASTQG
TGTSVCTIRG SLFSKIQDYC NSVEVTTASL FQSIWALTLA AYTGNDSTCF GYLASGRDLP
IAGIDKSIGA FTNMLVCRVN INRETEILQF VRTVHDQVMQ DLEHQHCSLA SIQHELGINS
DNPLFNSILS YQKQDDEPAG DEGFYDIVLN IGHATDHIEI VFDYNHACLS SIQAESILSL
MQSTAAALVQ HASGDHQTLR SVNMVSTEDI SDIWQWNSDV PVTVDDCVHH IITRTCHERP
QAPAICAWDG DWTYAEVNKL SDRLAHLLVS YGVGPEVVVP LCFEKSKWTP IAMMAVMKAG
GASVAMDSTQ PEERLRAIVN QVKSPIILSS FANEQLASRL ISELPSPTKV LTISDKELEI
LNVPSGSQLP HVNPSDTLYV VFTSGSTGVP KGVAVTHSNI ASAIKHQRHS LGFTSESRVF
DFSSYMFDVV WCNLLQGLSA GSCLCIPSDN ERKTDFMAAI VRMRANLVIL TPSAIRGLKL
DALNSLCNLH FIGEPLHVDT FRSVDESVKI SNLYGPTECT TFSTVQTICG RQHQSITIGK
GAGLNTWVAD IATGTALVPI GSAGELLLEG PLVAAGYRDD AVKTAAAFVY DPPFLLRGSV
GQPGRRGRLY KTGDIVRYNS NGTLTFLGRK DSQVKINGQR VEFGDIESHI NGALLPDFSE
GQALVEFVTP QGSSRPMLVA FVYFGPTVTE GMGEADLLSL AKRTAISLDE SLAARIPAYM
IPSAYIHLQK IAVTATGKTD RRRLREMAKD VTWDQLISTD SHGPDRCQPG TEMEIQLQIL
WGTVLGVESS LIGAHDNFMR VGGDSVGAIR LASSARELGF TLDVADILKN PKLSDMAKLM
IRTEPSQDIS IKEFSLLKPG SDVDRAVAET SALCGVDGNQ VEDLYPCTPL QEGLLALTTK
RPGDYIIRCI LELKRSTDVK KFCAAWQAVL ESTPILRTRI VDIAEQGLVQ AVIKQPAQWT
SAEASSLVDF MAADNEKTTG LGMPLVRFGL VQETNKHFFV LTLHHAVYDG WALNLVFEKL
ENFYAGSSRH ESPDFRHFVK HISGLDNDAA AKFWKDQLQG SEAPTFPSLP TATFVPKSEK
TILHTVEELQ WPKTNVTAFT LVRAALSLLT AAYTNSEDVC FGVTSNGRQV GLPGVERMIG
PTIATVPVRV RIDREQRLQA FLTQMQHQSI DMIAFEQFGL QQIRKSSPDA ERACDFQSLL
IVQPAEETAQ WQSDIIARDI GEGSDNPMGI QEVGTYALTL ECHLGPDKLL IKANFDSNVI
DELQVKRFTK QFEHVLRQIC CSGSGLAVSD IDTTSRQDME DIWEWNAVVP ESVNTPVHEL
ISSVARRLPH VQAVCAWDGN WTYRQLDDLS NYVAHHLVGL GVGSQDIIPL LFEKSKWMPI
AMLGVMKAGA ASVAIDTSQP KDRLRMIIDQ ANPTVALSSA DKLPLVRSLT KAQSFVVNGQ
GIDSLLKPSL NATLPVVDPS SRLYLVFTSG STGVPKGVII RHCNFASAIK HQKEAQGILP
ISRVYDFASY AFDVAWANAL LTFESGACLC IPSDADRKDN LNGSIARLKP THADLTPSAA
LVLSKESLQQ LDTLTLGGER LLAEYATKWS QFVTVKNSYG PSECTPTATF TEGMRRGYDL
GASIGKPAGL NTWVVDPVTG QSLVPIGGVG ELFLEGPLVG AGYLGDAKKT NAAFIHDPPF
LLRGNVVAQP GRRGTLYKTG DIVRYNSDGS LTFVCRKDTQ VKINGQRVEL AEIESHMALY
PATRQVATLL PSTGLCASKL VAMISLTDVN YDVSEDLAEN KIELASSEHD QLINEHIEAL
QSLLRESLPQ YMIPSLWVVL YNLPMTASGK QDNKALKFWL ENMDETLFSK INNANGSDII
RKPDTEGERA LSEKCSIVLN MPVDKINLDK SFIANGGDSI AAMRLASHYR TAGIPISVPT
LLQSKTLADF AAFSGATAIT GVSQEEHTDV PFELSPIQQW FFDQSPFMSQ QKHDRFYNQG
FYVRLRRTVG INDLESAFLS LVNRHAMLRS RFQHHGGKWK QIILSHSKRA LHLNLSQHLS
MSEIASLAQE RHRQIDIEKG PVFSVDICLL GQQQYLVMIA HHLVTDLVSW RIILDDLETI
LNGHSLTAAL PFQVWSRLQA ERAVSSTLEP HNLLSTDGVH NNLKFWKYTH DTPNCLADHR
LRSVTIDRET TAVLLGEANK AMNTEPVEIL LSAVWDAFLR TFPQRNSLTI FNEGHGREAW
SDEIDLSSTV GWFTTLSPIN IYRNDATSET DMVRLVKDAR RSLPANGWAY FTSRYLNPDG
QRAFESHNTV SEVVFNYHGQ FQQLESHQAL FEDIDLVDVR EQGRSISAGS LFNIEVAIEA
MQARFEFSVN QNIAHQSLIN QWIDQIQPSL EKICLVLLEA NPTHTLCDFK FISLDYQRLD
DLTSRLLPEI ESINHSTVEE IFSCSPIVDG MLLSQIKQPE SYKTLQQYEV LSSHDHPICL
DTLKVAWQKV ISRQPALRTV FIAGLDGSTA FYQALLKECS GDVVVVEAKT EEEALKAFSS
LPKVNYQQAK PPHRLALCQT PDDKVFCQIE MSHAITDGAS SSILIKDLID AYGDRLSSTD
LVKTTREFAS HLLAKPQSQI ISYWNTKLKG LEPCRFPSLS SPSREKHECS SEIGVFVEDK
MFAQIQDFCS INQVTPASLL KSAWALTLST YVQSQSVCFG YLASGRDLPI AGMDESVGAY
TNIMVCRADL DGRQPGVALV RQFQDQLMQD LSFQHISLAS IQHELGLASD QQLFNSIVSF
QRSGDDNEQS AEEGKLRFKN IDGLDPTEYD IVLGINQGTS SIEIDLEFSH SCLTSNQAKR
ILEHLESNIA AILHNEPPAL IGHQDEQDIW SWNSTVPDMA NICVHDLISK MVFRQPDAPA
VCSWDGDFTY AELDSFATRL ANSLSKMGIG SGSIVPICFE KSKWTPVAML AVMKTGAASV
TMDTSQPEER LQSIVAQVDA KLVISSTLKA ELAARLTTAT VLAIDKASMG AMADNTPLAA
VDPANSIYIV FTSGSTGTPK GVIITHTNYS SAIKHQQSEH GFKPSSRVFD FASYAFDVSW
SNFLHTLTIG ACLCIPSDDD RNNDPAGAID RLRCTHVDMT PSAASVLPAS TLAKLDTIVL
GGEKLSLEYA QRWSALTSVR NPYGPSECTP TSTITEINSA ELSKGKVSIG KGVGLNTWIV
DPATAQHLMP IGIPGELLLE GPLVGAGYLG DPVKTASAFI ENPEFLVKGA GPGIPGRRGR
LYRTGDLVAY NTDGSLSFVG RRDSQIKING QRVELGDIES HVSANLVSHD SAQVAVEVVS
PQASSNNILV AFVSFDDLNS INLNDEKLLA RTKAATEGIR EKLATQIPSY MIPSVYIPVT
VFPTTATGKT DRRRLREMAS SLTLEQLTSI NQAQQQYQPP TTPLEVALRE LWISVLKLGS
RKISTADNFF ELGGDSIGAM RLVGAARDHG LSLSVVDIFK HPKFSEMAAL LRSVDKTQSE
EPRVFQPTSL LSKHHNKDQI LSRLFDLGID LGNVEDILPV TDHQARSIAM THSASRDLLL
YHTLDSKGVP NMRKMRAVCN ELVNRYDLMR TLFIAHKDSF LQVVLKAFPV DITVLRIENA
SLEECTEELR LRDRDDELRY GSLLTKIAIL HQIRDNEYRL VVRISHAQHD GISLMKMWNA
FEEMYDDGSD DSLHIPSDTS FQEKSKASFS NYLHAVAGTN REQAKFYWRR LLKGSSMTNL
KPHASYALTF GEGPCVARHV PKSIAQGTGF TFSTVLKAAW AYVLAKHLAN DDVVFCNLTH
GRGLPGTQDV FGACVNIIPT RVSFTDGWTV GDLLSALNTQ QIASMEHENI GTREIVRDCT
TWPKWTYAGS IIYHHDFDDG EYIAHNRSMH VEQELDLSHG KVDMTDVHIT SKPDNNMFRI
ELDFAHGVVS ERDAELLAAK LTESIIVFCN VMDQPLLSPD QIRYLRTSTS LPSEKPLSAT
PTNEQLMVAS ISPTEMKSSL ESAWRDTFNC RLSPEVKAGK TIFDLGGDLV SASLISAHME
RQGYVLSVED VLGNPTLFSQ LTLLTKRSLR DVDV
//