ID A0A395I4Q2_ASPHC Unreviewed; 2622 AA.
AC A0A395I4Q2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Amino acid adenylation {ECO:0000313|EMBL:RAL15192.1};
GN ORFNames=BO97DRAFT_463045 {ECO:0000313|EMBL:RAL15192.1};
OS Aspergillus homomorphus (strain CBS 101889).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1450537 {ECO:0000313|EMBL:RAL15192.1, ECO:0000313|Proteomes:UP000248961};
RN [1] {ECO:0000313|EMBL:RAL15192.1, ECO:0000313|Proteomes:UP000248961}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 101889 {ECO:0000313|EMBL:RAL15192.1,
RC ECO:0000313|Proteomes:UP000248961};
RG DOE Joint Genome Institute;
RA Vesth T.C., Nybo J., Theobald S., Brandl J., Frisvad J.C., Nielsen K.F.,
RA Lyhne E.K., Kogle M.E., Kuo A., Riley R., Clum A., Nolan M., Lipzen A.,
RA Salamov A., Henrissat B., Wiebenga A., De vries R.P., Grigoriev I.V.,
RA Mortensen U.H., Andersen M.R., Baker S.E.;
RT "The genomes of Aspergillus section Nigri reveals drivers in fungal
RT speciation.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KZ824272; RAL15192.1; -; Genomic_DNA.
DR STRING; 1450537.A0A395I4Q2; -.
DR VEuPathDB; FungiDB:BO97DRAFT_463045; -.
DR OrthoDB; 2209130at2759; -.
DR Proteomes; UP000248961; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05918; A_NRPS_SidN3_like; 2.
DR CDD; cd19545; FUM14_C_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF07993; NAD_binding_4; 2.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 2.
PE 4: Predicted;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248961}.
FT DOMAIN 806..882
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2100..2182
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2622 AA; 285405 MW; 79610D5B94D7B647 CRC64;
MSKSTNPQSL NPLPSLARDD DGLDQHKEHD PGPCYFPSLG DDHAPGSGEW LQTRAPVPVI
QQPELRQLCQ TVDATVPAVL LGAWALVLRA YTATDAVSFG FVEEPVTQPS ICILNMPEDL
APGELVQQAQ GEWVRLRQVR SCALTGCGHS ARSAGTTPFN TCLAFVSSLS DGVKRERRMV
EGWIYDVPNK HGLLLEIDAQ RAEAALSCKT SMLTQDQAAG VLETFCVAVA RLMQDRNSSL
RGQSLLGDCD RERIYAWNAV APEQTSQCIH ELIQARCVRQ PERPAVCAWD GDFTYRQLSR
LSADLAAHLV SAGVGPEVFV PICLEKSRWV AVAMLAVMQA GGAMVLLDVS HPPARLQQIC
REVSAQVVLT SPESAAVARA LAPQVVVLGD VQQPAEQPDS KKPGLSESVT PDSALYAVFT
SGSTGTPKGV IIEHATFYAS VRPYTQALLL NEDSRVFQFA SYAFDVTIFD TLITLIAGGC
VCIPSDTDRW SDMARTIERF QVNHVSITPT VARLLYPHEV PTLKTLALGG ESLSAADLAR
WTDHVHVINL YGASECPIIS LRRRPRGDPG AGEVAYSTGS ASWIVDPQDH ETLMPIGAVG
ELLVEGPIVG RGYLNNPDAT TQSFIPMPSW MRQFRGYKEH QGRRIYKVGD LVAYKADGSL
RFVGRKDTQV KLRGQRIELN EVQHHLRQCF PEAADVVAEV VTPAREQRPP MLVAFIAQAQ
SDSTTQPPAA LLAEPTGEFL GQSERARSHM QLALPPYMVP AVFLPLRALP LTGTSKTDRR
RLRELAGALT QREQERFQLG LARRRPPATD MEKAVQRYFS AVLHIPGEEI GADDHFFRRG
GSSLSAMELV AAARRDKHRI TVKEIFDHPR LWEIASILQS GSDWTDSVPQ PFSLLGPIDV
QHVIRVSAAQ CSVDPDAIED IYPCTPLQEG LMALSMQGLG PSFVTEVALA VPAGLNLERL
ELAWGRLAQA SPILRTRIVV SDTIHGMLQV VVRERISWTK QVEAAPAPGL TAVLGGPLVH
LAICRAEESP DVSHQLVIHM HHAVYDGWTL PLLLQGFKDA YNELSLPARP FTPFIQYITS
TQGQDAYWKT MTNGFREAAF PPLPSATYHP VPKAAISTSA TIPPPGDRAF TSSTYISLAW
SLTQAQLQGS HDIAFGAVRS GRNAPVPGIE NLTAPTIATV PSRVVLTRED RIAHALQKLQ
KDTIDGIPFE QTGLQNIRRL GPDAARACAF QTLLVVQPER PPSADDSFLR ELTSSNDDHL
AWVTYCLTVI CQYDGDALRV EAVFDDQVVP EHQMQAILAQ FVRILRRLHE DPAVSIGEML
QFAPEMVSCF GQEEERSAFW NEEFGDGDEM PTFPRLPSTS YVPVLDQQLQ HSFADNLEAP
GPYATEAARY LASCDTVFGA ALNGPVLPFR VRTLQGEAVG EYLDVIRSRL QKIFARQSED
CQVIACAGPG PAAACGFQSL LAMRRGLSTD VPLCGDGRTR ALVIEIASNT TSTTVHARFD
SNVISVESVK RMLQQFEHVA LQLSANRTIA VKDVELASPR DKDDIYRWNS RIDERSETTV
HALIEARTVQ QPDAQAVCSW DGEMTYAQLD QVSSKLAAYL INLGVGCETY IPLCFEKSLW
TIVAMVAVLK AGAAFVPLDA SAPENRLRTM IQTVQATTLL CSRAQYDRYP SLAPTTIVLD
ASWERWLADQ PPRLSSTVSP GNAAYVIFTS GSTGTPKGIV IEHGAFCTAA LAHRAGLALG
RNRVLQFSSY AFDVSLGEIL CTLVHGGAVC VPSDQERADD IAAAINRMEV DYAFLTPSFA
STVDPSSVPT LRTLCLAGEP MTTTTLETWA SHVRLINGYG PAECCVISAS NRYVTVVSHP
ANIGTAVGGA CWVVDPENDQ ILAPVGAVGE LLIEGANLAR CYINQPELTQ RAFIPRPRWM
PFSRCNRLYK TGDLVRYQED GSLVFVARKD TQVKIRGQRV ELGEIEHQIM LVAGGGAGVS
AVVVACPTTG GPFARRLVAV LESSSLAAQG ETSQGTVLAP VPMRQLATVG VDVAAITHKI
RNVLPSYMVP DHFITVERLP RSLSAKLDRK RVQSWLMQPP SEVLPRWGGE AKSEVGNALG
TDETVAHAIS YKIVGLSERD SGVSPVQRGH DFPIAAAGLD SIQLTSLVGF LRQTYAVNLT
VRTLLDGTAT VRSLAALVAG DTTSDTQKPQ SIDLTGEVAR LVQTVDRDLA LAQPLPVPRA
QGRVVFLTGC TSLLGTEILH QLCESDEVRR VIVHVRARTD EEASTRCREA ARRARWWSEE
RHGPKLEAWA GDLGQPRLGL RNEQWACVSG SSPPSPQSPD STAVNPPLLV DAIIHAGAAV
NWNAGYELLR AVNVDATVDL IRAALTSPAR PQLVYVSGGH TWHPHETETA LADAVIRSGS
GYGQSKFVAE MVVRRFAGPR LSVVKPGLII GTPEEGVPNV DDYLWRLTAA AVGGESYSAE
AALDTGMLWI TSSARVAEAI VRNALAPVPL DRAITYITDG VAVAEYWDTV NEALGNNTRR
LTPVPHEEWV SRVTRAIDVD GRTHPLWPVR EVFEEVNGRL GGARFSDLGV DHHKSHVRAA
IRKNVEFLVR TGVLGAADQS HGPSTDEAFR RAGQVWSSHR TV
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