ID A0A395IBI4_ASPHC Unreviewed; 926 AA.
AC A0A395IBI4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE SubName: Full=Ras guanyl-nucleotide exchange factor RasGEF {ECO:0000313|EMBL:RAL17590.1};
GN ORFNames=BO97DRAFT_419827 {ECO:0000313|EMBL:RAL17590.1};
OS Aspergillus homomorphus (strain CBS 101889).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1450537 {ECO:0000313|EMBL:RAL17590.1, ECO:0000313|Proteomes:UP000248961};
RN [1] {ECO:0000313|EMBL:RAL17590.1, ECO:0000313|Proteomes:UP000248961}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 101889 {ECO:0000313|EMBL:RAL17590.1,
RC ECO:0000313|Proteomes:UP000248961};
RG DOE Joint Genome Institute;
RA Vesth T.C., Nybo J., Theobald S., Brandl J., Frisvad J.C., Nielsen K.F.,
RA Lyhne E.K., Kogle M.E., Kuo A., Riley R., Clum A., Nolan M., Lipzen A.,
RA Salamov A., Henrissat B., Wiebenga A., De vries R.P., Grigoriev I.V.,
RA Mortensen U.H., Andersen M.R., Baker S.E.;
RT "The genomes of Aspergillus section Nigri reveals drivers in fungal
RT speciation.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KZ824267; RAL17590.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A395IBI4; -.
DR STRING; 1450537.A0A395IBI4; -.
DR VEuPathDB; FungiDB:BO97DRAFT_419827; -.
DR OrthoDB; 4819765at2759; -.
DR Proteomes; UP000248961; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00882; Ras_like_GTPase; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF348; GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000248961}.
FT DOMAIN 420..545
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 673..911
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..71
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 926 AA; 102795 MW; F4F36FC0BCE4D743 CRC64;
MNSQLPNRER AVSSDRAEAA PVPQRPGLPN RTISAPAGGL YKLDPARMAM DSAKMERTLV
EEDERSPSAE GHRSSSARFG GEALADSLGE HGLPLSHAGN ESIRKPNFPH VSIAVVGPDH
VGKSTFIESA LEMKHSLSSR TMTKKMSLDG TVYLVRLLEI DTLEISIGSN GEVQWPRLGN
DTPPSVDGVL VLQDVTQPAS LANIKGLLAA LDASCIPHKL VASKCDMQTP NSPVEPVMDG
YEILRTCPDS PRSQKMCIAL VLRSVISDRN AAEYSSDRTV TPGWRHSRAS SETPTSVFSG
AAGGPITGAL DPGVDGYGVD RQLTDSTPSN GQGPRYARSN SHPLRPHTPP SGRLNQRKPS
APGESSPGKD FNRQHRLHAA WRNSGGSDAF SSFIEMGEEM DGPRSIPSSP GSKDKTPSES
SSNENGFTFD ELVDRLVAQP MSKHDSKFAS IFLCLYRKFA APSSLLSALI NRFERNERET
SDQLTRIADQ LRLLTVMAQW VSEYPGDLAY PKTRKRITDF VANLEKSHFY MFAAKEIGSY
LEVNTEDDNI GWPFRDGEVE EFDPTEPTFQ YSGRSSPSIF LGPPPLSDEG DEEEEDPIYN
MSALDLSEGA LESGSRLSAS MTNSFTAEKP GTVASQSFTA LNIESAQREA SHLNLTPRIP
LTKVQWRQFM EIPDEDFARE LTRIDWIMFN SFRPRDLVRH VSITGADKDK IHSLKHVNRM
IKQFNHVAFF VASVILLRDK PKHRAKALEK FMNVAFKLRR LNNYNSLGAL IAGINGTPVH
RLSQTRELVP MQTQKDFMRL VILMGTQKSH FAYRLAWDNS FAERIPFLPL HRRDLVSAEE
GNKTFVGDTK NRINWRKFEV MGEVVLGIQR SQKTPYPHLA KFDEVTRLIL DIKLSGDEED
LYTRSMQVEP SAGGDTGRKK FGWLRS
//
