ID A0A395LN65_9SPHN Unreviewed; 865 AA.
AC A0A395LN65;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=DL238_02245 {ECO:0000313|EMBL:RDS78503.1};
OS Alteriqipengyuania lutimaris.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Erythrobacteraceae; Alteriqipengyuania.
OX NCBI_TaxID=1538146 {ECO:0000313|EMBL:RDS78503.1, ECO:0000313|Proteomes:UP000254101};
RN [1] {ECO:0000313|EMBL:RDS78503.1, ECO:0000313|Proteomes:UP000254101}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S-5 {ECO:0000313|EMBL:RDS78503.1,
RC ECO:0000313|Proteomes:UP000254101};
RA Chen X., Liu J.;
RT "Erythrobacter nanhaiensis sp. nov., a novel member of the genus
RT Erythrobacter isolated from the South China Sea.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDS78503.1}.
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DR EMBL; QRBB01000001; RDS78503.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A395LN65; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000254101; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}.
FT DOMAIN 692..708
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 618..625
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 865 AA; 92043 MW; 370553A0F9053849 CRC64;
MMEQYHALKR EAGECLLFYR MGDFFELFFD DAKVAAGVLD IALTSRGESG GESVPMCGVP
VHSADGYLAR LIRAGHRVAI AEQVETPDEA KARAKAEGKP SSKVLVARQI IRFVTAGTLT
EDALLEPRRA NRLAAVCDVR GRMGIAACDI STGRMELEEA DAGGLSAALS RLGASEIVAP
EDWAMAPDEA TLRPASDFAS ERGRKRLQDL HGVSTLDAFG DFSRAMLAAA GGLLAYLEHA
GRGAMPFLLP PTVNASDALM AIDEASRTSL EITATQAGAR AGSLLGTVDR CVTSAGARLL
AEDLSAPLAR KPAIDGRLAL VRFFHEDPIL RSDTREALRA IPDIARALAR LVADRGSPRD
LGQVRDGLAQ ARMLHASLSR LPDLPALLTE LLPRLTGHAG LVDELGRALV PSPPTERSNG
GFIAEGYDAA LDSLRETSGN ARRAIAALEA GYRKETGVSS LKIKHNGVLG YFIEVPARHG
DALMAPDSGF THRQTMANAV RFNSLHLHEE ANRIAEAGGR ALAAEEAHFE SLAQLVVEAR
EAIARTADGL ARIDVAAGLA ERAAEGDWCA PQIEDAPCLD IVAGRHPVVE AALAKAGERF
VPNDCGLDDT GRLWLIGGPN MGGKSTFLRA NALIVLLAQA GSYVPAQSAR IGLVDRLFSR
VGASDNLARG RSTFMVEMVE TAAILAQATP RSFVILDEVG RGTSTYDGLA LAWAVAEAIH
EQNRCRCLFA THYHELARLA ETCEALSLHH VRAREWQGDL VLLHEVSEGP ADRSYGLAVA
KLAGVPAGVV DRASAVLAKL ERGREETGGL AAGLGDLPLF SAAFQAEEDA CDTLREKLSA
LDIDALSPRE ALDMLYELKR EAGES
//
