ID   A0A395MDF3_9HYPO        Unreviewed;       743 AA.
AC   A0A395MDF3;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Protein disulfide-isomerase {ECO:0000313|EMBL:RFN45952.1};
GN   ORFNames=FIE12Z_9799 {ECO:0000313|EMBL:RFN45952.1};
OS   Fusarium flagelliforme.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium incarnatum-equiseti species complex.
OX   NCBI_TaxID=2675880 {ECO:0000313|EMBL:RFN45952.1, ECO:0000313|Proteomes:UP000265631};
RN   [1] {ECO:0000313|EMBL:RFN45952.1, ECO:0000313|Proteomes:UP000265631}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 13405 {ECO:0000313|EMBL:RFN45952.1,
RC   ECO:0000313|Proteomes:UP000265631};
RX   PubMed=29649280; DOI=10.1371/journal.ppat.1006946;
RA   Proctor R.H., McCormick S.P., Kim H.S., Cardoza R.E., Stanley A.M.,
RA   Lindo L., Kelly A., Brown D.W., Lee T., Vaughan M.M., Alexander N.J.,
RA   Busman M., Gutierrez S.;
RT   "Evolution of structural diversity of trichothecenes, a family of toxins
RT   produced by plant pathogenic and entomopathogenic fungi.";
RL   PLoS Pathog. 14:e1006946-e1006946(2018).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RFN45952.1}.
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DR   EMBL; PXXK01000330; RFN45952.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A395MDF3; -.
DR   STRING; 2594813.A0A395MDF3; -.
DR   OrthoDB; 52245at2759; -.
DR   Proteomes; UP000265631; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   CDD; cd02961; PDI_a_family; 2.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 3.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   PANTHER; PTHR45672; PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED; 1.
DR   PANTHER; PTHR45672:SF3; THIOREDOXIN DOMAIN-CONTAINING PROTEIN 5; 1.
DR   Pfam; PF00085; Thioredoxin; 2.
DR   Pfam; PF13848; Thioredoxin_6; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 3.
DR   PROSITE; PS51352; THIOREDOXIN_2; 2.
PE   4: Predicted;
KW   Isomerase {ECO:0000313|EMBL:RFN45952.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265631};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..743
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017221149"
FT   TRANSMEM        693..710
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          16..158
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000259|PROSITE:PS51352"
FT   DOMAIN          274..416
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000259|PROSITE:PS51352"
FT   REGION          160..282
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        179..193
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        222..251
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   743 AA;  84309 MW;  F33BB683CE340502 CRC64;
     MRFSPLATLA GLSAFVLADE VKNPVSEPSV FNGKTVPSLV ELTPANWEEQ AKKNKFMMVK
     HFSPYCKHCT RFAPTFQTLY EFYYTSKPQV DDPEATFTKY YDFIFGTVNC VAYYDFCMEH
     EIQSYPTTIL YENGKVFEAL RGIKNMTVLT TTIEKALAKE HPGRPELVEL PNPGDKVYPP
     PKVEEKPTEA AVEKKETQAP AVKPAVEAEK PIEAVVEPAG KTEGKSLDDV TEMPKAEVKS
     DKAESAEKPA EDASKSSFGA DWKVPSTGQM LKKPKPQDPT PKYNLEGIST PLTPDNFDTL
     VTNSKDPWFI KFYAPWCSHC KAMAPTWQQL AKKMQGKLNI GEVNCEADHK LCTQMGVKAF
     PTIYFVTGAE KAEYKGLRGV GDFVTYAEGA IEVAGGVLDV DAESFKELEK TEEVLFVYFY
     DHATTTEDFK AIDALPLNLI GRGKIVKTSD PELYKRFKIT TWPRLLVSRE GRATYYTPIT
     PDEMRDVDSL VSWMKSTWLP LVPEMTALNA KQIMSHKLVV LAILNRDDED RLQSSISELK
     NAANEWVDRQ VQEFQLERKK LRDAKQMRIE EAQSRDDQRG LRNAKAIKID MDSTRRKEVG
     FAWVDGVFWQ RWIAATYNID VRDGERVIIN EEDRHKFWDT TPTGNQIMIS HTSIMDTLDK
     IVYGPNPIPP KYTISSFSKF FFDIKMNFID HPFLSMGFVI AVGFGVYSWL RNRTRRPRGT
     FFRDDNMGLK DGLLGQNGNA KSD
//