ID A0A395MFJ3_9HYPO Unreviewed; 1105 AA.
AC A0A395MFJ3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN ORFNames=FIE12Z_9111 {ECO:0000313|EMBL:RFN46667.1};
OS Fusarium flagelliforme.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium incarnatum-equiseti species complex.
OX NCBI_TaxID=2675880 {ECO:0000313|EMBL:RFN46667.1, ECO:0000313|Proteomes:UP000265631};
RN [1] {ECO:0000313|EMBL:RFN46667.1, ECO:0000313|Proteomes:UP000265631}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 13405 {ECO:0000313|EMBL:RFN46667.1,
RC ECO:0000313|Proteomes:UP000265631};
RX PubMed=29649280; DOI=10.1371/journal.ppat.1006946;
RA Proctor R.H., McCormick S.P., Kim H.S., Cardoza R.E., Stanley A.M.,
RA Lindo L., Kelly A., Brown D.W., Lee T., Vaughan M.M., Alexander N.J.,
RA Busman M., Gutierrez S.;
RT "Evolution of structural diversity of trichothecenes, a family of toxins
RT produced by plant pathogenic and entomopathogenic fungi.";
RL PLoS Pathog. 14:e1006946-e1006946(2018).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|PIRNR:PIRNR037677}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RFN46667.1}.
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DR EMBL; PXXK01000288; RFN46667.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A395MFJ3; -.
DR STRING; 2594813.A0A395MFJ3; -.
DR Proteomes; UP000265631; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|PIRNR:PIRNR037677};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000265631}.
FT DOMAIN 974..990
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 116..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1105 AA; 120333 MW; 571BA81E7287B960 CRC64;
MVPPVIGIRH LRPLASSSTS TSTAASRPVS TSASVAALHT SHPLAKAEDA AEAQAQALAI
THTAIATTTA SIPQTHRHIG HPLRYGFSIR PFLPVPSPHR PLQTRGKKTT TTFQLSELPQ
GLIQPKPLSP LPTSSKVSSP HDETTEPMPQ PLPLPSLPQD PPAYPTVVLQ ARQNMLKFDN
CVLLTRVGGF YELYFEHAEE YGPLLNIKVA SKKTNAGLVS MAGFPFFQLD RFLKILVQDL
NRHVAIAEEF PNSPTAKVKS GGLMHDRQVT RIVTPGTLID ENFMDPYANN YVMAVHIDQR
LGATETNNNI GRVPALDAGP VDHKSVSEPG SAHTVPSAVG VGRDVGQPQG SQDAMPLGLA
WLDLSTGHFC TQQANLASLP AILSRLSPRE LLLDQDLQAF PDHNIFAPLA EERGIISYAP
QLHDSPLLDP INWAPMLESA LSESEVIAFS SAEVHAASFL LGYVKDQLLG MSIKLQPPQR
NENVQVMAID KNSLRGLEIK QTIRDGVFRG SLLHAIRRTV TKSGARLLNE WLSAPSASLE
IITGRQDLVA LFIDDANVCD SVIILLRRSY DSQRLVQKFT LGRGDADDLL GLASTIDATR
EIVDLLKKAN TPSRKVKSPC LTSLLSRISM TKSLKLAQRI RDAIDEDGIE LQHEVEDSET
SQMLALAEDV VSNEGSLDDA ASLPKGKRKR PASIRDYYAE DNEAWIMKPA ASPTLKRLHA
DLATLIEEKI ALNESLRESL NAPSLSLRWT PGLGHIAHIK GKDARNLVDV QALSSSRSTR
SFHITAWTHL GQRLDQVRAQ IRAEEQAVFH SLREHVVKNI VNLRRNAAVL DELDIATSFA
KLAQEQSLVR PVMNNTTSHT IMGGRHPTVE GGLFEQGRGF VRNDCLVGSP KDGRIWLITG
PNMAGKSTFL RQNALITILA QIGCYVPASY AELGIVDAIF SRVGSADNLY QDQSTFMVEM
LETAAILKQA TSRSFVIMDE IGRGTTPEDG TAVAFACLHH LATVNQCRTL FATHFHSVAD
LAAAEGLCST EAGIVQTYCT DVVEDGQGSF FYNHKLQKGI NRQSHALKVA KLAGLPDKAI
DIARQVLHND VPEPNGSGEA RAGQD
//
