ID A0A395MMH2_9HYPO Unreviewed; 1028 AA.
AC A0A395MMH2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=F-box and wd-40 domain-containing protein cdc4 {ECO:0000313|EMBL:RFN48593.1};
GN ORFNames=FIE12Z_7173 {ECO:0000313|EMBL:RFN48593.1};
OS Fusarium flagelliforme.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium incarnatum-equiseti species complex.
OX NCBI_TaxID=2675880 {ECO:0000313|EMBL:RFN48593.1, ECO:0000313|Proteomes:UP000265631};
RN [1] {ECO:0000313|EMBL:RFN48593.1, ECO:0000313|Proteomes:UP000265631}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 13405 {ECO:0000313|EMBL:RFN48593.1,
RC ECO:0000313|Proteomes:UP000265631};
RX PubMed=29649280; DOI=10.1371/journal.ppat.1006946;
RA Proctor R.H., McCormick S.P., Kim H.S., Cardoza R.E., Stanley A.M.,
RA Lindo L., Kelly A., Brown D.W., Lee T., Vaughan M.M., Alexander N.J.,
RA Busman M., Gutierrez S.;
RT "Evolution of structural diversity of trichothecenes, a family of toxins
RT produced by plant pathogenic and entomopathogenic fungi.";
RL PLoS Pathog. 14:e1006946-e1006946(2018).
CC -!- PATHWAY: Protein modification. {ECO:0000256|ARBA:ARBA00043952}.
CC -!- SIMILARITY: Belongs to the WD repeat MET30/SCONB/SCON-2 family.
CC {ECO:0000256|ARBA:ARBA00007968}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RFN48593.1}.
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DR EMBL; PXXK01000203; RFN48593.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A395MMH2; -.
DR STRING; 2594813.A0A395MMH2; -.
DR OrthoDB; 587035at2759; -.
DR Proteomes; UP000265631; Unassembled WGS sequence.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19849; PHOSPHOLIPASE A-2-ACTIVATING PROTEIN; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00256; FBOX; 1.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50181; FBOX; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000265631};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 437..484
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT REPEAT 686..725
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 756..775
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 802..841
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 842..883
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 884..923
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..244
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..584
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1028 AA; 114379 MW; 9DFA260F4A9C163B CRC64;
MTPSPATSQA LEPRHPKPSQ TVSVNISEGQ NNRSRRFQLE VSECVETKTV TTTTRLTRKF
PHVFVRDPVP LENLDTKEYP LAMKPTPPEL IQFSYNMPGA LETDDEAEEP TDTQMTYSNG
RATPGRVSSE SPHESNTLVR VPKHRSQSPS EGYPRRSRAS RTSPTDSPES SAPTSNNPRR
APRSNQLNAV TDKLRRSIAH GSNRPSLERS SRAATGFLAT PDTSEAVISS DRPSRRRSSH
PERQHSPEAS SSTVSPHYEA TSPVESDSHT VFSSNVATPP ITDTDAEPFT DIDGSLQQPA
RPFNPRPSID VVAAQDASLP SPRLSPTLAA AQLHTTDAED EASFQTSNTD PSRWVDESQL
TEDDPSTALV PAGRSDDDFA LTRPDGSPHV VDTQTLLEAF DSMKTEMKTF MMYQFLRRCP
RPTLRVVANA VNPALKCDFL RQLPLELGYS VLSHLDHKDL CCAAQVSKHW RNLVDRNETG
WKALFDRDGY TLPPGELQKA ILQGWGWQDP VGATGYEKDL SMRNRLTSTE HELTRTFRQE
TASKSRASKR KRALNTYSAA ERSKRRASAQ EAVSREESKS QPEIRQHPSE GPLSAANAAA
TAVSDPQLGL PSLRELHLYK SLYRRHHMIR KSWTSGEVKP GHVAFAAHPR HVITCLQFDE
DKIITGSDDT LIHIYDTKTG KLRKKLEGHE GGVWALQYEG NMLVSGSTDR SVRVWDIERG
LCQQVFYGHT STVRCLQILM PTETGRDSSG QAIMQPEKPL IITGSRDSQL RVWRLPEVGS
RRYIQTGPPA HESDCPYFIR VLAGHTHSVR AISAHGDTLV SGSYDSTVRV WRISTGEALH
VLHGHLQKVY SVVLDHKRNR CISGSMDSLV KIWDLTTGAC LYTLEGHSLL VGLLDLRDEI
LVSAAADSTL RIWDPENGKC RNVLMAHTGA ITCFQHDGRK VISGSEKTVK MWDVKTGECV
QDLLSDLSGV WQVKFDERRC VAAVQRDQLT YVEILDFGAV RDGKPPEELG KRILLNEPEV
RAMIEEEP
//
