ID A0A395MQN0_9HYPO Unreviewed; 1274 AA.
AC A0A395MQN0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:RFN50120.1};
GN ORFNames=FIE12Z_5648 {ECO:0000313|EMBL:RFN50120.1};
OS Fusarium flagelliforme.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium incarnatum-equiseti species complex.
OX NCBI_TaxID=2675880 {ECO:0000313|EMBL:RFN50120.1, ECO:0000313|Proteomes:UP000265631};
RN [1] {ECO:0000313|EMBL:RFN50120.1, ECO:0000313|Proteomes:UP000265631}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 13405 {ECO:0000313|EMBL:RFN50120.1,
RC ECO:0000313|Proteomes:UP000265631};
RX PubMed=29649280; DOI=10.1371/journal.ppat.1006946;
RA Proctor R.H., McCormick S.P., Kim H.S., Cardoza R.E., Stanley A.M.,
RA Lindo L., Kelly A., Brown D.W., Lee T., Vaughan M.M., Alexander N.J.,
RA Busman M., Gutierrez S.;
RT "Evolution of structural diversity of trichothecenes, a family of toxins
RT produced by plant pathogenic and entomopathogenic fungi.";
RL PLoS Pathog. 14:e1006946-e1006946(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RFN50120.1}.
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DR EMBL; PXXK01000150; RFN50120.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A395MQN0; -.
DR OrthoDB; 54187at2759; -.
DR Proteomes; UP000265631; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR InterPro; IPR022257; PHM7_ext.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR PANTHER; PTHR13018:SF20; SPORULATION-SPECIFIC PROTEIN 75; 1.
DR Pfam; PF14703; PHM7_cyt; 2.
DR Pfam; PF12621; PHM7_ext; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265631};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 76..102
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 742..763
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 793..816
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 836..858
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 889..917
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 950..977
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 997..1022
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1034..1052
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 81..246
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 271..348
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 621..728
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 741..1020
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT DOMAIN 1192..1265
FT /note="10TM putative phosphate transporter extracellular
FT tail"
FT /evidence="ECO:0000259|Pfam:PF12621"
FT REGION 37..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 343..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1090..1113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..374
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..425
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..514
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1274 AA; 143796 MW; 50126C99C72425E3 CRC64;
MSSADPSGTG TAESATDIAA ITSSIASSLL SSAISATTTG TPASTSSDGP TKTSSGGIGV
TPPSETTSAA TSDRGIGIAT FFTALVVAVV VFSVQILAFL LLRNKLARIF KPKTYLVPER
ERTDSPPTGL AGMLKTLWHY NDREIINKCG LDAYFFLRYL KTLLIIFIPI CCIVMPILIP
INYVGGIGKE VNADEETRKQ ERDSNRPTGL DTLAWGNVSA KNVDRYGAHL LMGILVVIWV
CWVFFIELKI YVKVRQDYLT SAEHRLKASA TTVLVNSIPA KWLSEEALTG LFDVFPGGIR
NIWLNRDLSP LLEKVKERND IHQQLESAET DLIKSAKKAQ LKQAKAAEKK ERKEMKLKAV
TKKERAERHA QLDAEAQEMA NSSGGQAAGD KHEVPHSVDQ GVRESEHDMD QQEGHDIDKE
KSRGFKVPLL NPISKVGQGL LGVVSKAEKN VDNTLETTNG FMGLQQDEKR APSRGSERYR
IRPSTDEDEL SSPSDTLRVQ NQSRNTNRHS GESTAAMNPE RREFGKPGNT VRKIDNIDEI
YVKEDSKWWE FWKPPPGAYA SPVPQGDVAA AYRERKDAQS RPLWQRIKYA LPFVSPEIEE
GPIEYETAFN PDYKEDAEPA EWEKYLKKKD RPTHRLPLFG KKWLFPIPLV TKKVDTIYWC
REQLARLNVE IEEDQSHPER YPLMNSAFIQ FNHQVAAHMA CQSVIHHIPQ QMAPRMNEIS
PRDVNWDNMA FSWWQEWLRS GLVFAAVVAM LFLWAIPVAW TAALSQLDNL IRNNSWLSFL
RDNETVHKMA KSIAGVLPAV VLALLLFLVP VILGFFAEFK GVKTGSQKTE FVQRYYFVFL
FIQVFLIVSI ASFFAASIDA LVENFKGLKT FEDVLDLLAK NLPTAANYFF SYMILQALST
SSATLLQIGA LVMWYVIAKI LDSTARNKWS RNTKLNQVTW GRLFPIYTNF ACIGLVYCVI
APLISIFAII TFGLLWMAQR YVMLYVNRFE HDTGGVLYPR AINQTFTGIY FMELCMAGLF
FLAEDPTGKN VCTVHGVIMI VVLILTALYQ VLLNYSFGPL FRYLPITFED EAVLRDQAFQ
RAQDQRLGLI DGDELQEEEE EEEDVKQPEK HGENGNAIEM RRFGSVRRPM KQVGTWARGG
GQQLRKIAVV NKASDKNKRA SLYREKHRRK DIEAQRAIGE ALFGGFHDEI EDLTPEERDA
LTRHAFQHEA LRARRPTVWI PRDDLGISDD EIRRTQAYSD HIWISNEGTA LDSKVRVVYG
RAPPDFSEVD LINL
//
