ID   A0A395MSD1_9HYPO        Unreviewed;      1359 AA.
AC   A0A395MSD1;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=5-oxoprolinase (ATP-hydrolysing) {ECO:0000313|EMBL:RFN50597.1};
GN   ORFNames=FIE12Z_5162 {ECO:0000313|EMBL:RFN50597.1};
OS   Fusarium flagelliforme.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium incarnatum-equiseti species complex.
OX   NCBI_TaxID=2675880 {ECO:0000313|EMBL:RFN50597.1, ECO:0000313|Proteomes:UP000265631};
RN   [1] {ECO:0000313|EMBL:RFN50597.1, ECO:0000313|Proteomes:UP000265631}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 13405 {ECO:0000313|EMBL:RFN50597.1,
RC   ECO:0000313|Proteomes:UP000265631};
RX   PubMed=29649280; DOI=10.1371/journal.ppat.1006946;
RA   Proctor R.H., McCormick S.P., Kim H.S., Cardoza R.E., Stanley A.M.,
RA   Lindo L., Kelly A., Brown D.W., Lee T., Vaughan M.M., Alexander N.J.,
RA   Busman M., Gutierrez S.;
RT   "Evolution of structural diversity of trichothecenes, a family of toxins
RT   produced by plant pathogenic and entomopathogenic fungi.";
RL   PLoS Pathog. 14:e1006946-e1006946(2018).
CC   -!- SIMILARITY: Belongs to the oxoprolinase family.
CC       {ECO:0000256|ARBA:ARBA00010403}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RFN50597.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; PXXK01000132; RFN50597.1; -; Genomic_DNA.
DR   STRING; 2594813.A0A395MSD1; -.
DR   OrthoDB; 674at2759; -.
DR   Proteomes; UP000265631; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   InterPro; IPR049517; ACX-like_C.
DR   InterPro; IPR008040; Hydant_A_N.
DR   InterPro; IPR002821; Hydantoinase_A.
DR   InterPro; IPR003692; Hydantoinase_B.
DR   InterPro; IPR045079; Oxoprolinase_fam.
DR   PANTHER; PTHR11365:SF2; 5-OXOPROLINASE; 1.
DR   PANTHER; PTHR11365; 5-OXOPROLINASE RELATED; 1.
DR   Pfam; PF19278; Hydant_A_C; 1.
DR   Pfam; PF05378; Hydant_A_N; 1.
DR   Pfam; PF01968; Hydantoinase_A; 1.
DR   Pfam; PF02538; Hydantoinase_B; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000265631}.
FT   DOMAIN          10..229
FT                   /note="Hydantoinase/oxoprolinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05378"
FT   DOMAIN          249..554
FT                   /note="Hydantoinase A/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF01968"
FT   DOMAIN          567..757
FT                   /note="Acetophenone carboxylase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19278"
FT   DOMAIN          775..1327
FT                   /note="Hydantoinase B/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF02538"
FT   REGION          1335..1359
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1335..1349
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1359 AA;  149105 MW;  3DC9350337C3372C CRC64;
     MSETSQRGIR IAIDRGGTFT DCVGEHNGKE IIIKLLSEDP ANYKDAPLEG IRRIMSHFLG
     WDIPRGEALD TTKIDSIRMG TTVATNALLE RKGEKIAMVV TKGFKDCLTI GNQSRPKIFD
     LAIRKPDVLY EKVVEIDERV TLEDYAEDPE RTQTEAEAQV GTKEAEGKTL VRGLSGETVR
     ILKRADEEDI RSKLKDVYDQ GIRSIAVCLM HGYTYPDHEA LIGRVAKDIG FQHISLSHEL
     MPMIKLVSRA TSVCADAYLT PAIRKYIDGF QAGFEGGLGT RSVKEEKGAK GARCEFMQSD
     GGLVDVEKFT GLKAILSGPA GGVVGYAITS YDEETKTPVI GFDMGGTSTD VSRYGEGRYE
     HVFETTTAGV TIQSPQLDIN TVAAGGGSRL FFRNGLFVVG PESAGAHPGP ACYRKGGPAT
     VTDANLVLGR LLPEFFPNIF GENEDEGLDI EASRKVLQEL ADQVNKESDK NLTADEVAYG
     FLTVANETMT RPIRSITEAK GHDSSKHRLA TFGGAGGQHA VAIAESLGIQ QILVHRYSSV
     LSAYGMALAD VVDERQEPDS LVWKDDDSTV NELKKKMEKL KDQSRKSLQD QGFQEDEIVF
     EEYLNMRYRG TESALMIVRP TPEEAKEHFD GKEWDFGQAF VKQHRYEFGF TLDERDIIID
     DVRVRGIGKS FRHQDDTVDK QLKDLKQQEV SDKKKLNSQQ VYFEGGRKET PIFKLEDLEV
     GESIPGPAML ADGTQTIVVT PKATAIILKT HVVINLEKEG KRSESAKASA DREVDPIMLS
     IFGHRFMAIA EQMGRALQKT SVSTNVKERL DFSCAIFDAT GGLVANAPHL PVHLGSMSTC
     VRRQAEIWKG KLEKGDVIIS NHPSYGGTHL PDVTLLMPAF DEKGENILFY AASRAHHADI
     GGISAGSMPP HSRELYQEGA SIRSEKLVSG GKFNEKRVVE LFYEEPAKYP GCSGTRCLAD
     NINDLRAQVS ANQKGISLIE TLIAEYGEET VQFYMVHIQN NAEQCVRQLL KDVHKRFEGK
     DLSSVDFMDD GSPIRLKIRI DAEKGEAEFD FSGTGPEVYG NINAPQAITF SAIIYCLRCL
     ISEDIPLNQG CLKPIHVKIP PKSILSPSPG AAVVGGNVLT SQRITDVIFK AFQACAASQG
     CCNNLTFGFG GNQDGAEAVK GFGYYETIAG GSGAGSDWEG TSGVHCHMTN TRITDSEIFE
     RRYPVLLREF SIRSGSGGRG QHRGGDGVIR DIEFRIPLQV SILSERRVYR PYGLNGGGDG
     ECGLNLWVRN VEKANWETSL KQFHTKEDAG EVEYEERRIN MGAKNTASMK AGDRIIICTP
     GGGAWGAEGS ESVAKRKVDH TEAWRKGSGS ARDETALQA
//