ID A0A395MT46_9HYPO Unreviewed; 422 AA.
AC A0A395MT46;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE SubName: Full=Saccharopine dehydrogenase {ECO:0000313|EMBL:RFN50349.1};
GN ORFNames=FIE12Z_5383 {ECO:0000313|EMBL:RFN50349.1};
OS Fusarium flagelliforme.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium incarnatum-equiseti species complex.
OX NCBI_TaxID=2675880 {ECO:0000313|EMBL:RFN50349.1, ECO:0000313|Proteomes:UP000265631};
RN [1] {ECO:0000313|EMBL:RFN50349.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 13405 {ECO:0000313|EMBL:RFN50349.1};
RX PubMed=29649280; DOI=10.1371/journal.ppat.1006946;
RA Proctor R.H., McCormick S.P., Kim H.S., Cardoza R.E., Stanley A.M.,
RA Lindo L., Kelly A., Brown D.W., Lee T., Vaughan M.M., Alexander N.J.,
RA Busman M., Gutierrez S.;
RT "Evolution of structural diversity of trichothecenes, a family of toxins
RT produced by plant pathogenic and entomopathogenic fungi.";
RL PLoS Pathog. 14:e1006946-e1006946(2018).
CC -!- SIMILARITY: Belongs to the saccharopine dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00038048}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RFN50349.1}.
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DR EMBL; PXXK01000141; RFN50349.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A395MT46; -.
DR OrthoDB; 5479972at2759; -.
DR Proteomes; UP000265631; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005097; Sacchrp_dh_NADP.
DR PANTHER; PTHR12286:SF5; SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE; 1.
DR PANTHER; PTHR12286; UNCHARACTERIZED; 1.
DR Pfam; PF03435; Sacchrp_dh_NADP; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265631};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 13..142
FT /note="Saccharopine dehydrogenase NADP binding"
FT /evidence="ECO:0000259|Pfam:PF03435"
SQ SEQUENCE 422 AA; 45936 MW; C7F028A925875FB6 CRC64;
MPLLKDHGRQ YDVVVFGATG YTGKLTAEYI TTHLSTDLKW AVAGRNESKL KAVVEDCKKL
NPDRLAPAIE IANLNDQELS GLAKKTCVLL TTVGPYSLYG EHAYKACAEA GTHYVDVTGE
AAWVHKMIKK YEATAKKTGA ILIPQAGIES SPADLSTWAL AKAIRTELGS QTKDVTISLH
EVNSSPSGGT LATALSIWDV FTLNEIKEAS SPYAQSPVPH KEPKRPKSSI LQMILGVGSV
PNLGLLTTSV AGSTDVAVVE RTWGLLSETP SRKEEFYGPN FVWQERMKAR NWLHGIFIHW
LLVIGGVLLV SVAPLREFLK KRVVQPGQGA NREETAKDYV EYRGIAHPDS KEHAGKAAFS
RMWHHGGMYL LTAVLLGEIA ATILEDPIEL DGGSYTPACL GQGLIDRLDK SGLKLDVKII
DE
//
