ID A0A395MY94_9HYPO Unreviewed; 4921 AA.
AC A0A395MY94;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN ORFNames=FIE12Z_3562 {ECO:0000313|EMBL:RFN52179.1};
OS Fusarium flagelliforme.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium incarnatum-equiseti species complex.
OX NCBI_TaxID=2675880 {ECO:0000313|EMBL:RFN52179.1, ECO:0000313|Proteomes:UP000265631};
RN [1] {ECO:0000313|EMBL:RFN52179.1, ECO:0000313|Proteomes:UP000265631}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 13405 {ECO:0000313|EMBL:RFN52179.1,
RC ECO:0000313|Proteomes:UP000265631};
RX PubMed=29649280; DOI=10.1371/journal.ppat.1006946;
RA Proctor R.H., McCormick S.P., Kim H.S., Cardoza R.E., Stanley A.M.,
RA Lindo L., Kelly A., Brown D.W., Lee T., Vaughan M.M., Alexander N.J.,
RA Busman M., Gutierrez S.;
RT "Evolution of structural diversity of trichothecenes, a family of toxins
RT produced by plant pathogenic and entomopathogenic fungi.";
RL PLoS Pathog. 14:e1006946-e1006946(2018).
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RFN52179.1}.
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DR EMBL; PXXK01000076; RFN52179.1; -; Genomic_DNA.
DR STRING; 2594813.A0A395MY94; -.
DR Proteomes; UP000265631; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR048617; MDN1_AAA_lid_4.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 8.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 3.
DR Pfam; PF21108; MDN1_4th; 1.
DR PIRSF; PIRSF010340; Midasin; 1.
DR SMART; SM00382; AAA; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR010340};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR010340};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR010340};
KW Reference proteome {ECO:0000313|Proteomes:UP000265631}.
FT DOMAIN 4711..4912
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 753..774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4053..4601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2659..2686
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 4081..4110
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4111..4164
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4165..4209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4210..4237
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4259..4308
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4320..4334
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4344..4358
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4361..4409
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4434..4478
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4527..4592
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4921 AA; 551188 MW; 2B252E221DFC56D8 CRC64;
MGMIDVSRQR RSLLADATVL EILPAEILAI IQTDSSTKLL DAIAEAALCP PLTERIFAHF
EHVFPDICAR WILNPGNEPS RYVRIYSALA RILPFAPYLS TFIEYASSTA EQPTNSPSLR
LPPLKLDQDA ITQDGEVLLQ SLLVAWRLIS FDSRNFGPLT SAAFMQTLFN HESTAVRYLA
TRIFIQLLHG SDWKLESLIQ EHIGKSEAIL ADFDGRSIDY GFLSLYEQSR VKSFLALRQE
VQAAHEADNN ENPCLQTLTP YVVAYGNVIL PRPLGPTGEP SNLVLTPTTV SNLERLATML
RDPDPVMLYG LPGVGKTALV HEIAKQLGMY SNMVTLHLNE QTDAKMLIGL YSTDSKPGSF
QWRPGVLTTA VREGRWVLVE DLDRAPTEVL STLLPLIERK ELLIPSRGER IRAASTFRLF
ATVRTSRGMN GRENLPSMVG IRFWQTLNTQ PLAASELENV VVQTYPILRR LVPDILAVYA
RLSQIGNKPG ALARGRNVMD RQMTLRDLLK WCRRLRESLI ASGSKTGEEA ITNTTEDQMF
MEAVDCFVGS CPDAQIGKDL VFAIAEEMRV PKERVEYYLS THIPPLQESD NQFSIGREVL
RKKKQSNRVQ KSKRPFASTA HAKKLLEQIA VAVKLNEPVL LVGETGIGKT TVVQQLAESL
GHKLIAVNLS QQSEVGDLLG GFKPVNTRTL AMPLKEEFED LFSATGISAS KNQKYLEQVG
KCFAKGQWSR VSKLWKEAPK MFNKIVKELE RVQTEQAETR NGDEQPTKRR KTQSKLQTLL
DLRPRWDMFA RNLEQFDVQI SGGSGTFAFS FMEGNLVKAV RNGDWVLLDE INLASPDTLE
SIADLLTGPD EKPSILLSET GEIEKIEAHP NFRIFGAMNP ATDIGKRDLP VGIRSRFTEV
YVSSPDKDIK DLLTIIKTYL GSSSSKNDQA ADDIARLYLN TKRLAEEKRL VDGANEVPHF
SLRTLTRVLS YVNTIAPYYG LRRALYEGFA MGFLTLLDRD SEQMLVPLIS HHLFESHGNP
QSLLSQAPKH PNDGKQYVRF KNQNRDRQYW LFQGNETPIE RKDYIITPYV ERNLLNLVRA
TSTRRFPILI QGPTSAGKTS MIEYLANFTG NKFVRINNHE HTDLQEYLGT YISGSDGKLR
FQEGILVQAM RQGHWIVLDE LNLAPTDVLE ALNRLLDDNR ELLIPETQEI VKPHENFILF
ATQNPPGLYG GRKVLSRAFR NRFLELHFDD IPEEELETIL TQRSPDTSPP DCKRIVTVYK
ELSRLRQTSR LFEQKDSFAT LRDLFRWALR KGGLREEIAS DGFMLLAERV REEEERIAVK
EVIEKVFKVK INPQDLYSAT MAPELKDFVS HNNNQGVVWT HAMRRLYVLV SRALRNNEPV
LLVGETGCGK TTVVQLLAEA LKKELHIVNA HQNTETGDLI GSQRPVRNRG AIIDAMDVDV
KSVLQTLGLD ISGSVEERLE RYKALDASII SNIPEDVRER ISAHETRSKA LFEWADGSLV
ESMREGHFFL LDEISLADDS VLERLNSVLE PSRTLLLAEK GIDNSFVVGA EGFQFFATMN
PGGDFGKKEL SPALRNRFTE IWVPALSQSE DIYEIVKTKL KGDSKQLVEV VVKFAAWFGD
TFRSMASTPF SVREILVWVQ FINNFHSSDP VVSLVHGAST IFIDSLGANP SALLATDPKS
LGQQRQKCLG KLSELIGKDV SKVYETHPEL SMDDRSLTIG HFSIPRASTG VADPGFAFHA
PTTRLNAMRV LRALQMQKPI LLEGSPGVGK TTLVAALSQA CGQPLTRINL SDQTDLMDLF
GTDVPVEGAE AGNFAWRDAP FLQAMQKGEW VLLDEMNLAS QSVLEGLNAC LDHRGEVYIS
ELDQVFKRHP DFRLFAAQNP HHQGGGRKGL PASFVNRFIV VYADVFSDDD LNLIAAHNYP
KISPQVINQL IQFVSQLDHK LAIEKAFGSQ GSPWEFNLRD VLRWLKLLDS SDPLLQNAHV
DDFLDIIVRQ RFRTQRDREE VNDLFTLISG SAPRQHSLYH DISPLFGQVG LALLDRHPHS
QPERLPNIDI VPRLAELESL MICVKQNVPC ILSSPSGYGK SVLLEHVAAL AGKSLVVFPM
NADIDTMDLV GGFEQADPLR EVNAALRALQ QDLQNSIMSV VPEDIPNQAL QLLHLLDGFT
GDVDSLPAIT ACVKELLLKV PTNSEVATTL SKALVPLQHS LVLENPRFEW LDGVIVKALQ
MGQWLVLDNA NMCNASVLDR LNSLLEPNGF LSINEHCGPG GEPRIVRPHP DFRIFLTMDP
RYGELSRAMR NRAVEIHIHT PPPALDSSYN RVVSVESTLQ RYNTSKLAAD MTADESVQIV
ERALETLSIT DVTLLPRFAD TLSQSTASKE VLKTGVSGLL NFLHSSNGAD GVNAVSRLYT
LLSVPEALKP AQPLHPLNNF PVAQLLPSPD TGRWLGACLE FYQDLYHLHN SIEDQRHKAQ
VNNLNALNRL QRSLVSDRVG AVSKDATVKL ASFLVSTINA AKEWLTFNFE SSELWTERVV
ILRGVVRYLE RTVRLATEPD FDEAKFQAHL AQGANFLQKQ LDTSNGNQER EFVLILIDRL
GKDFTAGFKL STGLSMELLW HIFRPTPLPT KQLLDRTLEL EKLGSRFDTL RWKAGATIPD
LAKAMITLEK ASGIIRSDVP NLDTLLEALT AEIESLEGRI GTDEAERMPF MVEEFESLRQ
VSMLSPNSPD NAELRVLSNI PTQAGMMLAS SEHQAALLQS VENLVYQNQF SWDGKLIPSF
WSKLQRLGSV NLGSLALLEA ELPIAGRQLA ILSADVMENP LTRLNNVLSN LVLDVFTAHG
QGLKEAVVEA AQLVSQNPAN GSQSFDGVAS RIEQEHFRQI ATEHLIPALK ALAASQKDTQ
NQAHLSAFAW IHFSIGTVKL YVPDRVFDPQ SRPKMEREFL QEMHALLKER TDSLRTFEKL
FTGQDTNERI RLLEAEANAL GPLPEEVRPI YRPDQSELSR LHAEFSNVLK AVTGPTLSSA
LQILDNDPSR AAEELQLVKE NVLRLLDRLA TRFEAYQDMT RPTSNLLRCL MIGLSLCDAA
SARNLAPASQ QILEVTPFLG GSMWNQKDGD FSSRTFEFLN YMSVVASVEG FEKIGHHARE
LVFKSFHSLF DEWTKSLEAD RKEQAAKGSL YRFRGSQEDE EEIDTEEFNE LFPTFDDEEA
ASMPAVKKQD EVRDQSLRVA QMHKNLFLAP PDFSVALKDA CRSVGDRVTS ETIDHKNIDR
SLASKMLAGT MFFLNDKLES LISPTVDKSY NFYTDANVPE ARRLVDLMHK MKARFRELQM
VDEIGHMQPL ADVIQACDQV LELVHTEPLA KILPKVEYLH GHVYEWQFGG WASKIYGVLT
LHNLLTDTII RWRRLELSTW ANLFDMEQKK CQDDAYSWWF VAYQVVIAVP LSLVDVPNEM
EEYAASLISS LEMYFSTAIV GQYGARLALL RQLQSHLKLL AEDYPVLEPV LHSLCNFIQY
YSRYEKIMDE AVHKGRLPIE KKMKDVLLMA SWKDTNINAL RESARKSHQK LFRIIRKFRG
VLGQEAKQII EQGLPEEEVS RASHVEKKSA PANVPADVFS KLNDTMPGWI DGHKRLANVS
KTVSVMRKIS ENPEMTSDVP QIIDDFVSSL NESMVELRKE TPPFLTDENK DQVKHLKTRK
RKLFADTLRD LRQMGLKYNL GQDKLAEQES LSVVLASIQP VQLPENTSDA MEYHLHKILD
LVPKVRAASR DHSEDLTSAE IARSVGFVEG MLNLLLAQRN LISTGGSSLS LLKRSAAQFH
HLSLSQEHGA LVRKTCASDW TRLLPWLVQI LKYAIHLVEV HEKLGEVKHT SVLEHLKSWY
GRFDSLKAST AGLEQLPESV SSEAAVRAEA KFSDELTSFR SNLEELNREQ PMLSFVLVQI
AGWTSISENA LEVADNSMEL ATFANAISTL GDKILVAVEG AKKAAKEIPR KEDEPGWLIG
HSEGFTKLFT KLRISEVERA VTSCINMLQH MQLEDQHLSQ AAMSLMAVAS PILGEYVEFA
QQILMQVVDI HSSIAHMAYN MTKTFTQISS QGFCTPQEKS DETSGESGKV ESGTGLGDGE
GAEDISKDIQ PDEDLSELAQ EANKEESGEM EDEKDAVDMA DEELEGDMNS VDGAEDDEEG
SKNGDEEEEE ENDMDEEAGD VDDLDPTAVD EKMWDGDDEE KADKDQQGEK AKGQKKDDEQ
IAGDEDAQKQ DGEEQPDADD SGEQEAEEEE AGAEEEDVKN QEEMNKQEQT AQENDTLALP
EDMELDLGDD HESASDSDDL DDLSDIEEEK KEAEDQEMGD NEDEDSEDAA AQAQLKEEAG
EEAEIEEDEE TPEEKAGGKD EVDEEVKPEE EEKAEEQEDA MDQNQPPQDN ATTDTDNAAP
SDVKTSGQDQ NADSMDVDDN FQSNAAQQED GEMGEGAADQ DTNAGNKGST SQSKEVMDRA
DQDQNKPDSA RSDPFKKLGD ALERWHRQQE DIKDAEPSEA NEQNAPQDPS ADQGRKEFQH
LQDDETATDT QAMGTADDEQ VQPIDESMAI DEEKQDPTSR LMDEDKDETE QDPDKMDTAD
TEAPDTSKQD SDKDQDDTRS GVKTRQGNYD REPSPSEQEA QMLEDQDEAD IQETSTQLSI
THISDEERPL RDFGESMQQW TEFQTKTHSL SLALTSQLRL ILTPSQSTKL SGAFRTGKRL
NIKRIIPYIA SSYKRDKIWM RRSIPTKRTY QILLCVDDSK SMGETSSGTL AMESLVMVSR
SLTMLEAGQV GVMGFGSDVF TAHGLTEPFA SDAGAKILQK FNFGQDRTDI GLLIQRTIET
FRVARQQGSG NSDLWQLALI LSDGLTPSSA HEGIRRMLRE AMEERIMIVF IIMDDTGKKK
GDSVLELKEA KFVRDGGESK VVIERYLDTF PFQYYLIVHH LEELPSALAG LLRTWFAEVS
A
//
