ID A0A395P1B5_TRIAR Unreviewed; 596 AA.
AC A0A395P1B5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 12.
DE SubName: Full=4-coumarate-ligase {ECO:0000313|EMBL:RFU82136.1};
GN ORFNames=TARUN_78 {ECO:0000313|EMBL:RFU82136.1};
OS Trichoderma arundinaceum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=490622 {ECO:0000313|EMBL:RFU82136.1, ECO:0000313|Proteomes:UP000266272};
RN [1] {ECO:0000313|EMBL:RFU82136.1, ECO:0000313|Proteomes:UP000266272}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 40837 {ECO:0000313|EMBL:RFU82136.1,
RC ECO:0000313|Proteomes:UP000266272};
RX PubMed=29649280; DOI=10.1371/journal.ppat.1006946;
RA Proctor R.H., McCormick S.P., Kim H.S., Cardoza R.E., Stanley A.M.,
RA Lindo L., Kelly A., Brown D.W., Lee T., Vaughan M.M., Alexander N.J.,
RA Busman M., Gutierrez S.;
RT "Evolution of structural diversity of trichothecenes, a family of toxins
RT produced by plant pathogenic and entomopathogenic fungi.";
RL PLoS Pathog. 14:e1006946-e1006946(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RFU82136.1}.
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DR EMBL; PXOA01000006; RFU82136.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A395P1B5; -.
DR STRING; 490622.A0A395P1B5; -.
DR Proteomes; UP000266272; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43201:SF6; ACYL COA SYNTHETASE (EUROFUNG); 1.
DR PANTHER; PTHR43201; ACYL-COA SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:RFU82136.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000266272}.
FT DOMAIN 43..424
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 480..563
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 596 AA; 65355 MW; 5267C6262E7CAAC3 CRC64;
MANNKESRPA IKAMSSSSKA NLSILHGPAQ PVPIHKTFGR LLREQALSQP SALLVASDHQ
QKSLTYAEAD ARSDDLARGL LALGAKQGDR IAILMGNEVE YIETFFACTK IGAPVTLANY
AYSEQELHSV LSSCGVSTLI MVPRFDRYDY RPWIPNLRKG IPSLRNILVV NADKEPALVK
LDYEDYEDVV LRGRKSTVDL LALEANIHAR DVMNLQFTSG STGLPKASAL THSGIYNAGR
YIGSTMYLKA SDRICLPVPL FHSFGLIIGL ATATAFGASL ILPASIFNVE ATLACIPKYR
CTGLYGVTTM FVAEMAHPRF NDHDLSSLRF AILSGSAVPE PLMRKVWAAF GITQTHTNWG
LTEASSIVTM TRDTDSMAQR TVTSGRLFPG FSARIADPAT GRTVPRAQRG EICLRGNGIQ
AGYYGNPKRT AEAHRVSPED GLEWFHTGDE GFFDPDGFFV ITGRIKDMII RGGENISPLE
IEERLVAHPS IAQASVIGVP DAKYGEQICA FVEPTATSAE RPSDEELRAW VSETLAYFKR
PRYVIWLGSH AAFQAWPKTA SGKLRKPDLR IIAAEIMKQD EGEVEARPQE PVRARL
//
