ID A0A395RKJ1_FUSSP Unreviewed; 3141 AA.
AC A0A395RKJ1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN ORFNames=FSPOR_10518 {ECO:0000313|EMBL:RGP60638.1};
OS Fusarium sporotrichioides.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=5514 {ECO:0000313|EMBL:RGP60638.1, ECO:0000313|Proteomes:UP000266152};
RN [1] {ECO:0000313|EMBL:RGP60638.1, ECO:0000313|Proteomes:UP000266152}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 3299 {ECO:0000313|EMBL:RGP60638.1,
RC ECO:0000313|Proteomes:UP000266152};
RX PubMed=29649280; DOI=10.1371/journal.ppat.1006946;
RA Proctor R.H., McCormick S.P., Kim H.S., Cardoza R.E., Stanley A.M.,
RA Lindo L., Kelly A., Brown D.W., Lee T., Vaughan M.M., Alexander N.J.,
RA Busman M., Gutierrez S.;
RT "Evolution of structural diversity of trichothecenes, a family of toxins
RT produced by plant pathogenic and entomopathogenic fungi.";
RL PLoS Pathog. 14:e1006946-e1006946(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RGP60638.1}.
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DR EMBL; PXOF01000183; RGP60638.1; -; Genomic_DNA.
DR STRING; 5514.A0A395RKJ1; -.
DR Proteomes; UP000266152; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR InterPro; IPR022099; DUF3638.
DR InterPro; IPR022105; DUF3645.
DR InterPro; IPR046541; DUF6606.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13367; UBIQUITIN THIOESTERASE; 1.
DR PANTHER; PTHR13367:SF28; UBIQUITIN THIOESTERASE ZRANB1; 1.
DR Pfam; PF12340; DUF3638; 1.
DR Pfam; PF12359; DUF3645; 1.
DR Pfam; PF20255; DUF6606; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000266152};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 14..226
FT /note="DUF6606"
FT /evidence="ECO:0000259|Pfam:PF20255"
FT DOMAIN 1995..2219
FT /note="DUF3638"
FT /evidence="ECO:0000259|Pfam:PF12340"
FT DOMAIN 2337..2369
FT /note="DUF3645"
FT /evidence="ECO:0000259|Pfam:PF12359"
FT REGION 1805..1835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2739..2761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3105..3141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1808..1835
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2747..2761
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3141 AA; 356320 MW; 183ABF10BBB4DCC0 CRC64;
MSTTLEPEVL LQAVFHHVVL PSKLPSKNDA DNVGLACDLG SRLRRALAKF SNDRDHDAWN
IIVSSMKATA VLNQGLLIGH ELLEVFQDIA SGKKNIWLAL FVTQQNSALL IHRNEIEETV
VFEALQTAAP VKDVLAAKNG LTAEFPHRSV QVPFNVFNDM SFLRNLSQLV GQASYESFDQ
FAAKASKGGH LIAETRNSTD PALVIELLMS LLEGLGSGLE VQPVHHKCAG MGRVYYKFII
CAMLADILKD SVEHLHPEMT LQLRSKLCRR MAKLKADSAA CSSSLRPLYD DLFASTSRDF
GDIVRYATER VSLQWDEFKA RVARRIPTLP HRVSEADLYM RLDNSGTFLT SQLSQNTSFP
SRRISPDLPQ LQEGTVLEVG RLADRYISLQ ESEDVAAARL TATSEQPQQL CQSLSRGIID
LLTDVGDTVN KDSVLMSRHL LRLFELWTSM DEAATSICPL LENYHPLFIP DALDVLCLMT
RDEMVRLLRV QQYIRNRVAS HKKNLGTIFD NPRKGSSFPA QFVSSTVTGG QMLMTATLID
EASLTAQEST LSELERLTKR YDSLTQSLND LTCTCTKSPT GKKITHGCRR CPKFWQRKKL
KISVHEDFLP STDTDQHRAQ RAAILLELLI PEYLTAYRAA TWRLYLLGTT VYSSTPGVPK
LLLDDINELK KFSQTVNRAF TLASRKKSFR QTHYGKLKLP KTPDQVSFRF GAEMSYYDTV
SGLWADELPK VPWYQHLLGS WLPHGIPDPY ETPTGVLDMV LYHPSSYEIV ASESMCSHSI
SGGDFRAFQR AVSARGRRWL EILKEMAASN FDFSSRVTNS FLHRLAMQAG PAALEEGMLR
EVHWVFNSES FCDRLKERLE AWMDTMEQNP RQVDRMSSVV IFSLRLYHLC PQSFATQAHE
LLLRVRSVTS NWILQLQHEV RSTPDADMAG KAATFAFWAA LLCRQTFWGC SGHDDFEATV
LKDDPLPFFR SSIALQENLL DSLDRLPPHL RSLLTQDMSA SYQMRGIVEK WVDSDIGLVE
KAIDETWVDA SVLAKRSYSP WKKLTGKNSW WISSETVPTG SIAPQRVRYH LLQGHLLVDE
KPLGRLPLGI RDDESMQELF GGQYLLTRPS GLLDYQILAE MEGHQVHVGI RDGRITVKAL
FRGSTLQFIP RSMFKGPMGW DLPADLVDDC VHWLDLTTGN LEMRRKPRIW RRKPSNWVLN
IRRRRATRNT GTSLVEPNSE IGRKVRSIFE DFEDTKRLTI YQPATKPLSV EMKRLEIRFH
VNQRGLLFCP QLRAEVDPQQ DIGTLYGLRS RVTLRDTSNP KRKSVLVPIG NIEWEREGIH
IAVRIFNEGV YAKYTLNSVL GRLDCPSEPL LLYLKAAIHA LTSFPLPDDL TGKTGTEESR
HCLLSAHSQP WTPLAGFPQR ILSIIKSLSP ERTLYPPGIN LYQKVRWDQH LTSTIQHEDL
APLVALIERR SRELEVFGMT QSQQENVSCS VSVAHLRIRG RIRRQLYERI CFDSDSKILS
QSAQTDAFIP FRGQKISVKS RRVYRTIRAM LESDAGASRL PKLAPILERW KTFQGIKKSL
SDIDLAGTLD DGVSQVWGSL VQKLYEKDLT RTYDNHFSLA LLAFDDDVDI DAVMIWLVAL
LKSSRLSCIR PPNHTLYTNF RYFEEPSKDV FLSLALPDSF NHDKNGSMLT DDPAKDAASR
IASHILNMWP NPPLSKQEFG ASVKSLRLGV KNFSLKKTWQ KFYPELRRLK DNWELSAYLL
QLESAAEMLT DGQPKAEQKL YQNVWTPRPT RLKNRNAEGL RECFTAQVLM NDLLSRLKTH
DRSNAESQSW LEEQNHSSVG SYNPNTHNQA SELPVSQRPE LKVLQRIIQR LISSRLPSKQ
AYGEDLLVSL AALALPQQSR KALHSRPHLA SVEREITRCR LLLREQHDKI QNLASQDDEG
FAWLSKGQLW PCFSPVVILE QLRNENRLRV PHALINRIVE YGLLTARLQR YLRIEDAILR
RDDRWLEENF ETEGHSNWNP LKYPEWLLLE IDSNMLIRPI QVEVAHAIIS PPLMSNSVLQ
MNMGQGKTSC VMPMAAILLA DTTQLCRLVV PRALLLQTAQ VMQSRLSGLV GREVCHIPFA
RRSSTDDQAL ELYYSLHKST LVSGGVMLCL PEHSLSFKLS GLQKLADEEV KKAQKMMNIQ
AWLESSSRDI LDESDLTLSP KTQLIYPSGI PTMIDGHPQR WQLIEDTLSL VESHIPQLQA
KFKDGIQVWR RHQGFPIIHL LRPEVEDHLN ALLVDDICHG RLSYLQFKTD TSLDARRDVK
LVLSTTQLSA SVWENAIGSL TDESSGRKTL HLLHGLIPQR LLILCLKKSW NVQYGLHPDR
APIAVPFEAK GIPSQTAEYG HPDTALVLTC LSFYHAGLTK CQLLQSLQFI GNSEDPSSHY
QRLTSSQHLP VGLEHWHLLE MDNEAQITML WEHLRFEKHA VNHFMNNFAF PQHAKQFGLK
FQASAWDIPL LSVSMKRQGI TTGFSGTNDN KKILPRTIRQ DDLPTLIQTN AEVLVHLLEP
RNQKCFQAID QHGRHLNEIG ILELLRSKGI KILIDAGAQI LEMENHQLAA AWLDVCRQAQ
GAVYFDNNSR IMVRARFQKS PVPLLASPFA DNLDECVVYI DEAHTRGTDL KLPAYAQGAL
TLGISSTKDQ IVQAAMRLRQ LATTQSISFV APPEVYTSVL SLRSAHSPKV VASQPLKSTD
IVHWLLEQSC EASDNMMSLH IAQGFDFCRR TDALLEYRKS SQNKKNRDRL LQQTQQPEGQ
TLEQLYGPKQ EASSTSLKPF NSTHVQGFVN ELHGLEADLV KHRRRVCSSA FDEVEQEREV
EFEVHQLREK QNPTHLTALE FPGLDDALVQ FCEKSEVELS SLDFIQALDL IGDTNIGLKY
GIKGTCSNLF VSKEFSRTVQ TRKADASRCL MRPVEWVLWR PAVEIALIII PEEAELLLPK
LRRIQTPTTF LLTYMTPFTR SLMDIGTLAY YPVPTPEKEL AIPSWLSIEI GLMAGRLFLP
YDQYMQLRSC LEVDEMAEHS VVTDDIHCSR KRILPNFGVM NAKSLAKFLT EWLVHRSRLS
DIMHTPMGYL IQNRDLPENH PFFTSNTKSR AIGTVSLTSH EERIKNANLS AAHDGDDESE
WSDGGDEVDN PPLAKDDGVE R
//
