ID   A0A395RX43_FUSSP        Unreviewed;       944 AA.
AC   A0A395RX43;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=Importin N-terminal domain-containing protein {ECO:0000259|PROSITE:PS50166};
GN   ORFNames=FSPOR_7942 {ECO:0000313|EMBL:RGP64412.1};
OS   Fusarium sporotrichioides.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX   NCBI_TaxID=5514 {ECO:0000313|EMBL:RGP64412.1, ECO:0000313|Proteomes:UP000266152};
RN   [1] {ECO:0000313|EMBL:RGP64412.1, ECO:0000313|Proteomes:UP000266152}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 3299 {ECO:0000313|EMBL:RGP64412.1,
RC   ECO:0000313|Proteomes:UP000266152};
RX   PubMed=29649280; DOI=10.1371/journal.ppat.1006946;
RA   Proctor R.H., McCormick S.P., Kim H.S., Cardoza R.E., Stanley A.M.,
RA   Lindo L., Kelly A., Brown D.W., Lee T., Vaughan M.M., Alexander N.J.,
RA   Busman M., Gutierrez S.;
RT   "Evolution of structural diversity of trichothecenes, a family of toxins
RT   produced by plant pathogenic and entomopathogenic fungi.";
RL   PLoS Pathog. 14:e1006946-e1006946(2018).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the importin beta family. Importin beta-2
CC       subfamily. {ECO:0000256|ARBA:ARBA00038423}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RGP64412.1}.
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DR   EMBL; PXOF01000116; RGP64412.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A395RX43; -.
DR   STRING; 5514.A0A395RX43; -.
DR   Proteomes; UP000266152; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProt.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040122; Importin_beta.
DR   PANTHER; PTHR10527:SF3; FI21453P1-RELATED; 1.
DR   PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR   Pfam; PF13513; HEAT_EZ; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000266152}.
FT   DOMAIN          33..101
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50166"
FT   REGION          360..405
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        387..402
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   944 AA;  105362 MW;  F1D3F8F12ADA2278 CRC64;
     MSSWEPSPDS LQQLAVCLKD SLSGFNKTAQ KQADLMLQQA KNSPDINNYL AFLFSSSSPP
     NGLQFTEQDF HLVRSAAGIM LKNNVRSEWK SIPEDSLQLI KLAVPMCLQD KNSQIRNFAG
     NIATEIVRRG GLLTWPELLP QLLDLVGNTS GQTSNEAQEG AMSALAKICE DNYRQLTKEV
     NGQRPLNYVL PQFIAATKSQ LPKVRTGALT AINVFTPRES QAMLNSIDDL LQHLFILASD
     SNVDVRRQVC RAFVNLVETR PDKLQPHISG LVDYIITQQK GDDEELACEA AEFWLAVGEH
     DNLWRALEPY IHKIIPVLLE CMVYSGEDIA LLGGASDDEE EEDREEDIRP AFAKKALARK
     ANGEVGDSAD PSQNGGGFAK LGGMDEDPEE GEVDDYDDGD DANPDERWTI RKCSAAALDV
     FARDFQAPVF EAIFPYLSQH LKHNEWPQRE AAVLALGAVA DGCMDVVVPH LPELVPYLIS
     LLEDSEPVVR QITCWTLGRY SSWAANLEDK DKDQFFLPLM DGILRHMLDK NKKVQEAAAS
     AFANLEDKSG KILEPYCGPI VQQFVHCFAK YKDRNMYILY DCIQTLAEHI GPVLASPDLA
     GKLMPALIDR YNRVSDQSRE LFPLLECLSY VAMALGDAFA PYAEAIFIRC VNIIHMNLEQ
     TLAAANNPVL DQPDKDFLVT SLDLLSAIIQ ALNDDKSAAL VKSSQQSFFE LLSLCMEDPT
     DEVRQSAYAL LGDCARYVYP LLQQYLSTII PILLKQLDMD SVLDEDMDSG FGVVNNACWS
     VGEISMQHKG NMGPYVQDLL QRFVEIMTNP RVPKALNENA ATALGRLGLD NSEQLGPHLS
     TFAEEWISIM NEVEATEEKA TAFKGFSMIV GRNPQAMEKE LLNYFTAIAR YRDMGLKSPA
     RQELHDVFQK VIDIYKQMIP DFSSFIGQLQ QRDRQALETH YSLS
//