ID A0A395RZJ4_9HYPO Unreviewed; 1423 AA.
AC A0A395RZJ4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=5'-3' exoribonuclease 1 {ECO:0000256|PIRNR:PIRNR006743};
DE EC=3.1.13.- {ECO:0000256|PIRNR:PIRNR006743};
GN ORFNames=FLONG3_9218 {ECO:0000313|EMBL:RGP65427.1};
OS Fusarium longipes.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=694270 {ECO:0000313|EMBL:RGP65427.1, ECO:0000313|Proteomes:UP000266234};
RN [1] {ECO:0000313|EMBL:RGP65427.1, ECO:0000313|Proteomes:UP000266234}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 20695 {ECO:0000313|EMBL:RGP65427.1,
RC ECO:0000313|Proteomes:UP000266234};
RX PubMed=29649280; DOI=10.1371/journal.ppat.1006946;
RA Proctor R.H., McCormick S.P., Kim H.S., Cardoza R.E., Stanley A.M.,
RA Lindo L., Kelly A., Brown D.W., Lee T., Vaughan M.M., Alexander N.J.,
RA Busman M., Gutierrez S.;
RT "Evolution of structural diversity of trichothecenes, a family of toxins
RT produced by plant pathogenic and entomopathogenic fungi.";
RL PLoS Pathog. 14:e1006946-e1006946(2018).
CC -!- FUNCTION: Multifunctional protein that exhibits several independent
CC functions at different levels of the cellular processes. 5'-3'
CC exonuclease component of the nonsense-mediated mRNA decay (NMD) which
CC is a highly conserved mRNA degradation pathway, an RNA surveillance
CC system whose role is to identify and rid cells of mRNA with premature
CC termination codons and thus prevents accumulation of potentially
CC harmful truncated proteins. {ECO:0000256|PIRNR:PIRNR006743}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR006743}.
CC -!- SIMILARITY: Belongs to the 5'-3' exonuclease family.
CC {ECO:0000256|PIRNR:PIRNR006743}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RGP65427.1}.
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DR EMBL; PXOG01000234; RGP65427.1; -; Genomic_DNA.
DR STRING; 694270.A0A395RZJ4; -.
DR Proteomes; UP000266234; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004534; F:5'-3' RNA exonuclease activity; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR CDD; cd18673; PIN_XRN1-2-like; 1.
DR Gene3D; 1.25.40.1050; -; 1.
DR Gene3D; 2.170.260.40; -; 1.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 2.30.30.750; -; 1.
DR Gene3D; 3.40.50.12390; -; 2.
DR InterPro; IPR027073; 5_3_exoribonuclease.
DR InterPro; IPR016494; 5_3_exoribonuclease_1.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR041385; SH3_12.
DR InterPro; IPR040992; XRN1_D1.
DR InterPro; IPR047007; XRN1_D1_sf.
DR InterPro; IPR041106; XRN1_D2_D3.
DR InterPro; IPR041412; Xrn1_helical.
DR InterPro; IPR004859; Xrn1_N.
DR InterPro; IPR047008; XRN1_SH3_sf.
DR PANTHER; PTHR12341:SF83; 5'-3' EXORIBONUCLEASE 1; 1.
DR PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR Pfam; PF18129; SH3_12; 1.
DR Pfam; PF18332; XRN1_D1; 1.
DR Pfam; PF18334; XRN1_D2_D3; 1.
DR Pfam; PF17846; XRN_M; 1.
DR Pfam; PF03159; XRN_N; 1.
DR PIRSF; PIRSF006743; Exonuclease_Xnr1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR006743};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|PIRNR:PIRNR006743};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR006743};
KW Nonsense-mediated mRNA decay {ECO:0000256|PIRNR:PIRNR006743};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|PIRNR:PIRNR006743};
KW Reference proteome {ECO:0000313|Proteomes:UP000266234};
KW RNA-binding {ECO:0000256|PIRNR:PIRNR006743}.
FT DOMAIN 20..246
FT /note="Xrn1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03159"
FT DOMAIN 294..692
FT /note="Xrn1 helical"
FT /evidence="ECO:0000259|Pfam:PF17846"
FT DOMAIN 743..931
FT /note="5'-3' exoribonuclease 1 D1"
FT /evidence="ECO:0000259|Pfam:PF18332"
FT DOMAIN 935..1160
FT /note="Exoribonuclease Xrn1 D2/D3"
FT /evidence="ECO:0000259|Pfam:PF18334"
FT DOMAIN 1178..1248
FT /note="5'-3' exoribonuclease 1 SH3-like"
FT /evidence="ECO:0000259|Pfam:PF18129"
FT REGION 469..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1288..1423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1423 AA; 160094 MW; 61A8C3A3665B2293 CRC64;
MGYVAPSLSK LLHELTSRYS VPKFFRWLSE RYPAISQLIA ENRIPEFDCL YLDMNGIIHN
CTHKDAGEDV SFRLSEEEMF IRIFNYIEHL FGKIKPKQLF FMAIDGVAPR AKMNQQRSRR
FRTALDAEKA REKAIKEGVE IPKEEPFDSN CITPGTEFMA KLSQQLRYFV NKKVSEDTDW
QGCEIVLSGH EVPGEGEHKI MEYIRNAKAQ PNYNHNVRHC LYGLDADLIM LGLLSHDPHF
CLLREEVTFG RASKTKSKEL EHQNFYLLHL CIVREYLEME FQELREEGTL SFPFDLERVI
DDFILMAFFV GNDFLPNLPS LHINEGALAN MFRIYKSILP KCDGYINENG VINMERLQRL
LGELSNTEID AFETDVSDEK WFASKQMEKK LENKNAETKA PKGGQLVLTS AQRDLWKQKI
RPYISKRSDE PLDLGTSLKA ADRKFVQDLA DSMHLQWSTK EDDEGHRHLI VSFPPKDNND
DDDDEEEEEG NLAAYRVMKT YDKALVVDLT PEDAQKQYEK LYQDKYQGWK TKYYLQKFEE
WAPDNYDKEL TALCENYVQG LQWVLYYYYR GIASWPWFYG YHYAPLISDV VKGVGADLNF
KKGQPFLPYE QLMGVLPDRS KKIVPKVYHD LMTNPDSPII DFYPRDFELD MNGKKMDWEA
VIKIPFIDEK RLLDAMRPKN DLLEPDEKAR NGFGVPLKFT YSPEVDFVYP SPLPGVFPEI
QNCRCIENIF DLPDVEGLEY LSGLTSGALL NIDALAGFPT LHTLPYTAQL VEGYGVNVFS
ADSRNPSVCV TLTETENRSK IETWKAKLGQ RCFVGYPFLQ EAKVIKVQDE LFSYELADNG
KDVITKDHNN REAADWAREA EYIEDWHAKR LAIIIGQVEC LVYVHMLKGL IRTEEGALTK
EYAENPSIRS TYAAQTIVDE VVNEDERFIE KEALPIDEEF PRGTRAFFLG DYAYGRPLEV
AAHTGNKAEV VVSILKNKEQ DFAKQIIHQA ARSNPYTPSF AVAKQLGIHP LVLSKITSSY
QIINSAGLRL NLGLNLKFEG RKLKVLGYSR KSHTGWEFSG IAIKLIADYM VAFPDFFAAI
QREPQKSEVL ETDLWKDPSV ASQRVKEIVA WLKKQETSKF ERVPLEAEQL DSEIVKALAH
VGEQVHAASQ DTDIKKMRSV PRSALLKPSD AEMVLGSQNF TLGDRVTYVS AAGKVPIATR
GTVVGISRTA TALLLDVVWD TSFMSGTTLN ERAPMFRGQT VASSSVLNTT NKQVVSTTSK
SQQRKPVIAA QGGYANVGVT QYKDAPAPGP LRGGWSGALN GNNSPGRNPG RGRGNGARGG
APNLMHSTLV YRNGPPNGAA QGQDDNGNGT RGRGGRGRGR GNHHGPPAAD GAPQEQMYGN
VPPPASLDQP RGRGRGRGRG GRGRGGPNRG RGSGGAGGNG SQG
//