ID A0A395S4V4_9HYPO Unreviewed; 2434 AA.
AC A0A395S4V4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Vacuolar membrane-associated protein IML1 {ECO:0000256|ARBA:ARBA00018529};
DE AltName: Full=Vacuolar membrane-associated protein iml1 {ECO:0000256|ARBA:ARBA00021881};
GN ORFNames=FLONG3_8517 {ECO:0000313|EMBL:RGP67390.1};
OS Fusarium longipes.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=694270 {ECO:0000313|EMBL:RGP67390.1, ECO:0000313|Proteomes:UP000266234};
RN [1] {ECO:0000313|EMBL:RGP67390.1, ECO:0000313|Proteomes:UP000266234}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 20695 {ECO:0000313|EMBL:RGP67390.1,
RC ECO:0000313|Proteomes:UP000266234};
RX PubMed=29649280; DOI=10.1371/journal.ppat.1006946;
RA Proctor R.H., McCormick S.P., Kim H.S., Cardoza R.E., Stanley A.M.,
RA Lindo L., Kelly A., Brown D.W., Lee T., Vaughan M.M., Alexander N.J.,
RA Busman M., Gutierrez S.;
RT "Evolution of structural diversity of trichothecenes, a family of toxins
RT produced by plant pathogenic and entomopathogenic fungi.";
RL PLoS Pathog. 14:e1006946-e1006946(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Vacuole membrane
CC {ECO:0000256|ARBA:ARBA00004148}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004148}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. {ECO:0000256|ARBA:ARBA00008170}.
CC -!- SIMILARITY: Belongs to the IML1 family.
CC {ECO:0000256|ARBA:ARBA00005643}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RGP67390.1}.
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DR EMBL; PXOG01000207; RGP67390.1; -; Genomic_DNA.
DR STRING; 694270.A0A395S4V4; -.
DR Proteomes; UP000266234; Unassembled WGS sequence.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd04449; DEP_DEPDC5-like; 1.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR045838; DEPDC5_CTD.
DR InterPro; IPR027244; IML1.
DR InterPro; IPR048255; IML1_N.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13179; DEP DOMAIN CONTAINING PROTEIN 5; 1.
DR PANTHER; PTHR13179:SF8; GATOR COMPLEX PROTEIN DEPDC5; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF19418; DEPDC5_CTD; 1.
DR Pfam; PF12257; IML1; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR SMART; SM00049; DEP; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000266234};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 179..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 434..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 502..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 539..557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 564..583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1923..2009
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT REGION 65..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 710..732
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1106..1147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1360..1394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1423..1458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2027..2070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2269..2288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2315..2340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2389..2434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..97
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..617
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 712..732
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1118..1147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2027..2067
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2321..2335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2414..2434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2434 AA; 271917 MW; 3621A86A58109F62 CRC64;
MSSFNHFNIK RQAHTLSRTS TDQSWNPFRH VSWKRPVRTL SEAGLEGQQR NRNQAIGEEL
THAVTEPGRS GPAREWSTAE TMMDTRRSKE DGYDREKVAG SGSPIDGSDD IPVSQRSLVG
DENQLRNRKR EDVPAAADQN IDLEKRKLDR RQSSKLFRHV EPKEPFTVRN QLERTFLNSY
INILLIAAPV GIALNYVHSV NRIAVFVVNF IAIIPLAAIL SFATEEIALR TGEVLGGLIN
ATFGNAVELI VAILALVDGK VIIVQTSLVG SILSNLLLVL GFCFFFGGLR REAQYFNETV
AQTAASMLAL AVASVIVPTV FDQARDTPAT NVARLSRGTA VILLIVYAAY LLFQLKTHSS
TFRQEGQKVA AKPWSRGGGS GDIRQGLMVP GALVGGGMTG REENERLSQM LMNPHRLPKP
DDEEDEEEEP QLHFWVAVAT LTIATVLIAL CAEFMVDSID AVTKTGGVSE EFVGLILLPI
VGNAAEHATA VTVAIKDKMD LAIGVAVGSS MQVALFLIPL LVIIGWGMGN DDMNLSFDLF
QVATMFVAVL LVNYLIADGK SHWLEGWLLI CLYSIIAVCS WWYPTHSDEI ISRPVESSSI
TSERQPDPMS RNGSSRNPVP RMGPPHWRQF SKSSLDRSQA EVPASPASVS THSTIKDEKR
TRIERRCTVT VNEGYARDEV LLNFDVVGAD VKPGMLMCIS TVRDDLRKIS AGHGSSSKQN
QDASKGTSGT QNGDGAGFKY FFVAKDMPQE TKTRNPDVEV YVLKHIADAF GMKKGKVDAK
NPATEASHVE LSFKDQYLSR SDIWRMTVGE LTGRTVYKGQ SVLFMGTIKA QVTAIYVDSR
RTHSAFFTRD TRPIFRSESA RYVLFIQMAK EMWEFDAESS GEIMFNKVVN GFLPALFKRW
AMLKAKHLVS IVLFARVEYD TGLTAEFDSL SGDFYTGIQP SGLRRPYKDF YRVVVSEMGS
GEWTKILHQL KVEFNFFRRD ISLYHHKLNA QAEINGPDSI PKDTPSSRVK AESTYAMYGN
VLEAINLASS QFAHDHIDRD LTRTGISIAV ISPGSGVFEV DYETLRRTTE ALVGNGIGID
LICMPKMPLH SVPLFKYRNP QYSDEHGHAH RSSFSRSFHS RDSTPNHPTP VIGSYQSLGE
SFSPSKGTSL SRRADPLISM ATSDQWCFAL PQWLHVSFWT GASDEALSYE GIALSVSNKV
MQDDEDEFNI RCRMYALQMR SVLETNEIET TPLQVDTHFP ANITEPPSSQ KYRNTGINDT
VYIPNRRPPE GLFEHTYGFQ RFVPDRLARP GEKSLWKQLQ EFDDHRAKIS HGRSRHHSSR
YAKDLDEITR RQLAEDSGLY GTSLPEKKAP ILGASARKLS MNITDGDKPS PTSLKKTAEP
TPRPPKQVAK QPKLMRQISL GQRGFGIAAP KAAVAEIKAE TVNASGVSSG EGKQPSTPRI
RPELRPSSPQ TITSHPSTVS IQKYRLDAQD TIVEGVPMTP SIPILKRNNS GLDVAAMQLR
TASTTIGSSF NNRQQKREDD RDLRYSDALR ADDAQKLYTN KLRAGALSDA VQDLPTTLSP
TTAITPWLTL VNPSNPESLA IDDTVLYSRW QHVYPQITQM KVQKWKALCC PASVPLTTEY
FPSKTQFDTE YHRHPYTVEQ DADDDLVETP KSRQEFVQEL ISLRFSQGFQ VVVGPLVARA
FGQNLIKIGD IFSRDQPLED GTSIFMSVGN SIHQLSCVNG TEVEVNIFMR KPTDTSFTSQ
GFSPIYKPAI RTLLDDTYEA REIDLLTPRT DRNWNMIDSY IAGHHDEMTD SLRFWRARFV
LIPVLRKDVP ISRTQTGDHA EEVRIEGIKR LAQSWQKYRY IPPSERRYHS VGQQKRRRDP
NPLDIVWKTD DPSVVIAAEV ETLPLTEGVE GANRKGLVSA KERFKKSNLN LSTLADAMQL
PIENGGVRLQ NRRWHLRLYS ACFIGSDMVT WLLDNFEDLD TREDAEALGN ALMVHEEPKS
GNHKDNGLFV HVDKRHQFRD GNYYYQIASE FAKPHVGWFN TRRTVVPPTP SLEASNRDSP
RTLMSARSVE ESGSPASTST TPTISLPHSG KRPKVVLSKV IKYDVDHRKR SYRPERIDLH
YDRLHNPDTC YHIRIDWMNV TTKLVEDAVE SWSREASQYG LRLVELPIRE ACSITETNPF
RRPYRIKLAA RPPDQKPETY IDPNSLGPTT SPNKHFYQTA ILKKFDFVLD MEAASNFPSN
VDVSYSWGKP DYKYTQYIHR SGTLLAEITD EGDLLILANR LYSNRPAGPR DKDIRTVEPL
PERGGRMSSY GPYSTFGMTE SATLSSPLLK PTHYLHSPGL KPVDQQQNKP VPATTPDPDS
LNAEIDEFCK NKTALEEFYK EALEKGQKVQ GTPATAPVAT PLEAVPEASI PTLGLPPGVL
GGNDGAPTKR LNSPMSFLRR SSVQYDGGSS LTGR
//
