ID A0A395SEE7_FUSSP Unreviewed; 1138 AA.
AC A0A395SEE7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE AltName: Full=Mitochondrial DNA polymerase catalytic subunit {ECO:0000256|ARBA:ARBA00031966};
GN ORFNames=FSPOR_3798 {ECO:0000313|EMBL:RGP70778.1};
OS Fusarium sporotrichioides.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=5514 {ECO:0000313|EMBL:RGP70778.1, ECO:0000313|Proteomes:UP000266152};
RN [1] {ECO:0000313|EMBL:RGP70778.1, ECO:0000313|Proteomes:UP000266152}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 3299 {ECO:0000313|EMBL:RGP70778.1,
RC ECO:0000313|Proteomes:UP000266152};
RX PubMed=29649280; DOI=10.1371/journal.ppat.1006946;
RA Proctor R.H., McCormick S.P., Kim H.S., Cardoza R.E., Stanley A.M.,
RA Lindo L., Kelly A., Brown D.W., Lee T., Vaughan M.M., Alexander N.J.,
RA Busman M., Gutierrez S.;
RT "Evolution of structural diversity of trichothecenes, a family of toxins
RT produced by plant pathogenic and entomopathogenic fungi.";
RL PLoS Pathog. 14:e1006946-e1006946(2018).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RGP70778.1}.
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DR EMBL; PXOF01000049; RGP70778.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A395SEE7; -.
DR STRING; 5514.A0A395SEE7; -.
DR Proteomes; UP000266152; Unassembled WGS sequence.
DR GO; GO:0005760; C:gamma DNA polymerase complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006264; P:mitochondrial DNA replication; IEA:InterPro.
DR CDD; cd08641; DNA_pol_gammaA; 1.
DR Gene3D; 3.30.420.390; -; 2.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR InterPro; IPR002297; DNA-dir_DNA_pol_A_mt.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR041336; DNApol_Exo.
DR InterPro; IPR047580; POLG_palm_dom.
DR InterPro; IPR012337; RNaseH-like_sf.
DR PANTHER; PTHR10267; DNA POLYMERASE SUBUNIT GAMMA-1; 1.
DR PANTHER; PTHR10267:SF0; DNA POLYMERASE SUBUNIT GAMMA-1; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR Pfam; PF18136; DNApol_Exo; 1.
DR PRINTS; PR00867; DNAPOLG.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000266152};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 693..923
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
SQ SEQUENCE 1138 AA; 129364 MW; 303B3A5CB93D88B8 CRC64;
MFVPAAASPF RGSTACFSRI AHHQGFRRHA LRNQVRWLAA VADNAKSEKL KTLALPSEAR
HNEIGVQQLS SHVFEQIFPD GVKPPPQELV ELSKDHLRRH DLLGKNTDKS EPIAFDIPPL
QGRTLDEHFH KLGIDAAEPF LTYAKQFARA NPPPKPRQWV HQSGWTKYYP DGTTEKVEAP
DEEMLSFDTE VMWKISPFAV MACASSPTAW YAWLSPWLMG ETENDRQLIP FGDPTKDRII
VGHNVGFDRA RVLEEYSMTQ TRNAFLDTMS LHVAVNGMCS QQRPTWMMHK KNREMRERVA
TETPDHDLAT MLSTQGIHDE ADLWVERSSV NSLRDVAKFH LNVSIDKTIR NDFGELDREG
VLAKLDELLT YCAADVSITH RIYQIVFPNF LSTCPHPVSF AALRHLSSVI LPVDSSWDVY
IKNAEATYQK LSDAVQERLI GLTETALKMK DNPDEYENDP WMQQLDWSGQ EIKMAKGKGD
EPPRPVARQK KPGMPRWYKD LFQTNDSPIN ITVRTRVAPL LLKMSWDGYP LFWSDKYGWT
FRVPRAEATK YTAKQAVECK FDETEIKLRD DHAHSYFKLP HKDGPTARCA NPMAKGYLSY
FESGMLSSEY TYAKEALEMN ASCSYWISAR DRIKSQMVVY DKDIRKLNKT RGRRKLNDPG
FILPQIIPMG TITRRAVENT WLTASNAKKN RVGSELKAMV KAPKGYCFVG ADVDSEELWI
ASLVGDATFK LHGGNAVGFM TLEGTKSAGT DLHSRTASIL GITRNNAKIF NYGRIYGAGL
KFAATLLRQF NPNLSEKQTM DTASRLYANT KGTKTNRKVL YKRPFWRGGT ESFVFNKLEE
FAEQDKARTP VLGAGITEAL MGRYISKGGY LTSRINWAIQ SSGVDYLHLL VVAMDYLIRR
FNIDARVALT VHDEIRYLVN DKDKYRTALA LQVANVWTRA MFSQQVGIND LPQSCAYFSA
VDIDHVLRKE VDMECITPSH QTPISPGESI DINTLLEKGE AARLDPAIVP DPKYAPKLDH
IEYTPRVPVM EGIQESAQET LPFLKAQIAS DEKEIRDIVY TLQKERIAAM PKKERPLSKK
ELQGVLPYRA YPQLMPMDEP FILTEAMKEN QNAYANKNNN KLGLGKYSNR MYRPTWRV
//