ID   A0A395SR46_FUSSP        Unreviewed;       823 AA.
AC   A0A395SR46;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=phospholipase D {ECO:0000256|ARBA:ARBA00012027};
DE            EC=3.1.4.4 {ECO:0000256|ARBA:ARBA00012027};
GN   ORFNames=FSPOR_997 {ECO:0000313|EMBL:RGP74933.1};
OS   Fusarium sporotrichioides.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX   NCBI_TaxID=5514 {ECO:0000313|EMBL:RGP74933.1, ECO:0000313|Proteomes:UP000266152};
RN   [1] {ECO:0000313|EMBL:RGP74933.1, ECO:0000313|Proteomes:UP000266152}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 3299 {ECO:0000313|EMBL:RGP74933.1,
RC   ECO:0000313|Proteomes:UP000266152};
RX   PubMed=29649280; DOI=10.1371/journal.ppat.1006946;
RA   Proctor R.H., McCormick S.P., Kim H.S., Cardoza R.E., Stanley A.M.,
RA   Lindo L., Kelly A., Brown D.W., Lee T., Vaughan M.M., Alexander N.J.,
RA   Busman M., Gutierrez S.;
RT   "Evolution of structural diversity of trichothecenes, a family of toxins
RT   produced by plant pathogenic and entomopathogenic fungi.";
RL   PLoS Pathog. 14:e1006946-e1006946(2018).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RGP74933.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; PXOF01000018; RGP74933.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A395SR46; -.
DR   STRING; 5514.A0A395SR46; -.
DR   Proteomes; UP000266152; Unassembled WGS sequence.
DR   GO; GO:0070290; F:N-acylphosphatidylethanolamine-specific phospholipase D activity; IEA:UniProtKB-EC.
DR   GO; GO:0004630; F:phospholipase D activity; IEA:UniProtKB-EC.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006654; P:phosphatidic acid biosynthetic process; IEA:InterPro.
DR   CDD; cd09138; PLDc_vPLD1_2_yPLD_like_1; 1.
DR   CDD; cd09141; PLDc_vPLD1_2_yPLD_like_2; 1.
DR   Gene3D; 3.30.870.10; Endonuclease Chain A; 3.
DR   InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR   InterPro; IPR016555; PLipase_D_euk.
DR   InterPro; IPR015679; PLipase_D_fam.
DR   PANTHER; PTHR18896:SF128; PHOSPHOLIPASE; 1.
DR   PANTHER; PTHR18896; PHOSPHOLIPASE D; 1.
DR   Pfam; PF00614; PLDc; 1.
DR   PIRSF; PIRSF009376; Phospholipase_D_euk; 2.
DR   SMART; SM00155; PLDc; 2.
DR   SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR   PROSITE; PS50035; PLD; 2.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022963};
KW   Reference proteome {ECO:0000313|Proteomes:UP000266152}.
FT   DOMAIN          180..207
FT                   /note="PLD phosphodiesterase"
FT                   /evidence="ECO:0000259|PROSITE:PS50035"
FT   DOMAIN          608..635
FT                   /note="PLD phosphodiesterase"
FT                   /evidence="ECO:0000259|PROSITE:PS50035"
FT   REGION          521..547
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   823 AA;  95444 MW;  F4B1807CB2C2278E CRC64;
     MGEHKRTESL MEKLKLHDAK VHLVHQKHDE EHEQRCDEKR SAICEQNRYK SYFPIRAGNR
     VKWYVDGRDY FWAVSIALEN AKESIYIADW WLSPELFLRR PPYKEQEYRL DKLIKRKAEA
     GVQIYVCVYK EVEQALTCNS AHTKHALRKL CPKGTPGYGN IHVARHPDHN VFENFGDMTW
     YWAHHEKFIV IDYEIAFVGG LDLCFGRWDN HQHPLADIHP ADVRDEIWPG QDFNNNRVMD
     FQKVDSWQDN ELSKADYGRM PWHDVAMCIQ GSAAYDVAEH FILRWNFVKR DKYKRDERFN
     WLMLEGREGE DEDLVGVQRP KHPVGDYVRH PYTPLSEKKL DGIGTVNCQI VRSSADWSSG
     ILTDHSIQNA YIEIISKAQH YIYIENQFFI TATGDQQAPV KNQIGRAIVD AIVRAAKEGR
     KFRVIVLIPA IPGFAGDLRE EAATGTRAIM DYQYKSICRG EHSIYGQCRA EGVDPTKYIF
     FFNLRSYDRL NKTPGIIKAE KETGVSYQQV QRAEAEEIMS EGIHGSYDPE DSEGDEHMRR
     DKDKKELDED IKKTMEARKK FEAALPPENI HTTSSVAHHA MADTGEGLKG ESWFEEDPES
     EIKNWIQEEL YIHGKLLLVD DRIAVCGSSN LNDRSQLGDH DSELSVVMED TRLIPSVMDG
     QPYEAGYHAA TLRRYLWREH MGLLPPQEHD ASKDINAMPV NVNPDNDIYD RDESYKFVED
     PLSDEVWDMW TSRADKNTML FRHLFHADPD DHIKTFEDYD RYLPPKGVKA GHIFDQFLPV
     ADAREKLSQI KGHLVWFPLE FLSEAEMAEW GLQVNAVTES IYT
//