ID   A0A396L2J4_9FIRM        Unreviewed;       287 AA.
AC   A0A396L2J4;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=Methylcobamide--CoM methyltransferase {ECO:0000313|EMBL:RHP08938.1};
GN   ORFNames=DWZ93_07425 {ECO:0000313|EMBL:RHP08938.1};
OS   Dorea sp. AF36-15AT.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Dorea.
OX   NCBI_TaxID=2292041 {ECO:0000313|EMBL:RHP08938.1, ECO:0000313|Proteomes:UP000266623};
RN   [1] {ECO:0000313|EMBL:RHP08938.1, ECO:0000313|Proteomes:UP000266623}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF36-15AT {ECO:0000313|EMBL:RHP08938.1,
RC   ECO:0000313|Proteomes:UP000266623};
RA   Zou Y., Xue W., Luo G.;
RT   "A genome reference for cultivated species of the human gut microbiota.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RHP08938.1}.
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DR   EMBL; QUDV01000004; RHP08938.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A396L2J4; -.
DR   OrthoDB; 2135496at2; -.
DR   Proteomes; UP000266623; Unassembled WGS sequence.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004853; F:uroporphyrinogen decarboxylase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.20.20.210; -; 1.
DR   InterPro; IPR038071; UROD/MetE-like_sf.
DR   InterPro; IPR000257; Uroporphyrinogen_deCOase.
DR   PANTHER; PTHR47099; METHYLCOBAMIDE:COM METHYLTRANSFERASE MTBA; 1.
DR   PANTHER; PTHR47099:SF1; METHYLCOBAMIDE:COM METHYLTRANSFERASE MTBA; 1.
DR   Pfam; PF01208; URO-D; 1.
DR   SUPFAM; SSF51726; UROD/MetE-like; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000313|EMBL:RHP08938.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000266623};
KW   Transferase {ECO:0000313|EMBL:RHP08938.1}.
FT   DOMAIN          24..213
FT                   /note="Uroporphyrinogen decarboxylase (URO-D)"
FT                   /evidence="ECO:0000259|Pfam:PF01208"
SQ   SEQUENCE   287 AA;  32220 MW;  4B7880122E2DD345 CRC64;
     MISDFRCTFD NAIGISTEIT KDLKLSFPDA YMHADTMAKI AHAMKQKEGA AFCMLPFCHT
     VEAEAMGGIV NMGDGNLGPR AKEYCCTSAA ELLELPEIDC SKGRIYEVLK ACQRLREQGE
     HVALMISGPF TIFNVLIDPK YVFKAMRKQP ELMRDIFQKI ERELLTYIKI AVEYGVDMIS
     YADSSGGVNI LGPKMAEQVV MDFTYDFLKK AIELLDGKAM LLLCPKTTLA LIGTEKACYV
     DHELPEVMRY GEACVSLIGQ VPVAGQMCIK NIDYQLENKK FREIRLY
//