ID A0A396L4H3_9FIRM Unreviewed; 586 AA.
AC A0A396L4H3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Diguanylate cyclase {ECO:0000313|EMBL:RHP06388.1};
GN ORFNames=DWZ93_13355 {ECO:0000313|EMBL:RHP06388.1};
OS Dorea sp. AF36-15AT.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Dorea.
OX NCBI_TaxID=2292041 {ECO:0000313|EMBL:RHP06388.1, ECO:0000313|Proteomes:UP000266623};
RN [1] {ECO:0000313|EMBL:RHP06388.1, ECO:0000313|Proteomes:UP000266623}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF36-15AT {ECO:0000313|EMBL:RHP06388.1,
RC ECO:0000313|Proteomes:UP000266623};
RA Zou Y., Xue W., Luo G.;
RT "A genome reference for cultivated species of the human gut microbiota.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RHP06388.1}.
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DR EMBL; QUDV01000010; RHP06388.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A396L4H3; -.
DR OrthoDB; 9804955at2; -.
DR Proteomes; UP000266623; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:UniProt.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:UniProt.
DR CDD; cd01949; GGDEF; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.30.450.350; CHASE domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR006189; CHASE_dom.
DR InterPro; IPR042240; CHASE_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR45138:SF9; DIGUANYLATE CYCLASE DGCM-RELATED; 1.
DR PANTHER; PTHR45138; REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEM; 1.
DR Pfam; PF03924; CHASE; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF08447; PAS_3; 1.
DR SMART; SM01079; CHASE; 1.
DR SMART; SM00267; GGDEF; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50839; CHASE; 1.
DR PROSITE; PS50887; GGDEF; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000266623};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 96..189
FT /note="CHASE"
FT /evidence="ECO:0000259|PROSITE:PS50839"
FT DOMAIN 312..443
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
SQ SEQUENCE 586 AA; 67487 MW; 056325D5DE9A2CFC CRC64;
MKKQTLVPLI VFLLGICLVS LIVYKTDTHE KEQRHITAQL NVATYGEQIK NEITNGIEIT
DTLKQILISE DGEIHQFETI AGNLMSDSIE SVQLAPNGVV TDIYPANENE AGKIDLLHDK
DRRKISCYAR DNHTIITQGP FKLKQGGYGI AVRNPVYLKD KNGHEYFWGF TIVILRVPDI
FSDSISALSN FGYEYKISKT VAPWSDTYKV VYQSDGQTNH PVSYTFTIGD ENWKFEVSPK
SGWRNATLLT IIIGMFLTIS LLLSVLTRIW LVENEHKKKF QILARTDSLT NIYNRYGFDE
FTEKMIQKNP KAHFVAALLD IDDFKFINDI YGHNYGDRAL KNLADSMKTF FPSDALLGRN
GGDEFCILLP NCTFAEADIQ LQKFTKLPKS FSYHGKEHAF YISLGYAEYP TFASNRSQLM
RCADAALYEI KLHGKNGCMV YREGLRSGAR KQLGFTFKDI SEHLPGAFII YRADKEDDEL
FFANDEFLHM SGYKDIDELF RLTEKSFRNL IREDEQQQIE SSIWEQIDNG NENDYIHFHL
RKANGTYFSV LDHGRIVESP QYGKVFYVLF MDLEDMHIRY NDKFAR
//
