ID   A0A396LGF2_9FIRM        Unreviewed;       328 AA.
AC   A0A396LGF2;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=Integrase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=DWZ93_10345 {ECO:0000313|EMBL:RHP07934.1};
OS   Dorea sp. AF36-15AT.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Dorea.
OX   NCBI_TaxID=2292041 {ECO:0000313|EMBL:RHP07934.1, ECO:0000313|Proteomes:UP000266623};
RN   [1] {ECO:0000313|EMBL:RHP07934.1, ECO:0000313|Proteomes:UP000266623}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF36-15AT {ECO:0000313|EMBL:RHP07934.1,
RC   ECO:0000313|Proteomes:UP000266623};
RA   Zou Y., Xue W., Luo G.;
RT   "A genome reference for cultivated species of the human gut microbiota.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing
CC       the cutting and rejoining of the recombining DNA molecules.
CC       {ECO:0000256|ARBA:ARBA00003283}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family.
CC       {ECO:0000256|ARBA:ARBA00008857}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RHP07934.1}.
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DR   EMBL; QUDV01000006; RHP07934.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A396LGF2; -.
DR   OrthoDB; 9801717at2; -.
DR   Proteomes; UP000266623; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; Intergrase catalytic core; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   InterPro; IPR004107; Integrase_SAM-like_N.
DR   PANTHER; PTHR30349; PHAGE INTEGRASE-RELATED; 1.
DR   PANTHER; PTHR30349:SF87; PROPHAGE INTEGRASE INTD-RELATED; 1.
DR   Pfam; PF13495; Phage_int_SAM_4; 1.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU01248}; Reference proteome {ECO:0000313|Proteomes:UP000266623}.
FT   DOMAIN          48..130
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000259|PROSITE:PS51900"
FT   DOMAIN          151..323
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000259|PROSITE:PS51898"
SQ   SEQUENCE   328 AA;  38488 MW;  C7B5E3958CF2CAD1 CRC64;
     MEQKIMEVMR RMQDILSKEQ LRELQSALRV TFNGCELQPR SELMVLDDSW NGDLEDFLMS
     KALEGKSQAT IIRYRYELER LLAYINKAVI DITDSDISNY MRVYKRIRNI KNSTLKGVRS
     IYSSFFSWLR DRDRIRKNPM VLVEDIKVPI RVREPFTDAE REKLLRECRT LRDKAMMEFL
     YSTAVRVGEL VKLNRGDIRF STKDLIVCGK GDKERVVYLN ERTHMYLLEY LESRTDTNPA
     LFVSLRSPHK RLTDKGVEDI VRRTGRRVGV KAYPHKFRGT SITNALNRGM PLQEASCMAG
     HVKSDTTLRY AQLDQDSVRY HHKKYLSA
//